2024
The effects of Shaoma Zhijing granules and its main components on Tourette syndrome
Zhao Q, Hu Y, Yan Y, Song X, Yu J, Wang W, Zhou S, Su X, Bloch M, Leckman J, Chen Y, Sun H. The effects of Shaoma Zhijing granules and its main components on Tourette syndrome. Phytomedicine 2024, 129: 155686. PMID: 38759346, DOI: 10.1016/j.phymed.2024.155686.Peer-Reviewed Original ResearchTourette syndromeChina National Knowledge Infrastructure (CNKI) databasesNerve damageRepair of nerve damageClinical trialsEffective treatmentImprove sleep disordersNeurotransmitter imbalanceSleep disordersReducing neuroinflammationSyndromeComprehensive searchClinical applicationChinese medicine compoundObsessive-compulsive disorder
2017
Risk of Irritability With Psychostimulant Treatment in Children With ADHD: A Meta-Analysis.
Stuckelman ZD, Mulqueen JM, Ferracioli-Oda E, Cohen SC, Coughlin CG, Leckman JF, Bloch MH. Risk of Irritability With Psychostimulant Treatment in Children With ADHD: A Meta-Analysis. The Journal Of Clinical Psychiatry 2017, 78: e648-e655. PMID: 28682529, DOI: 10.4088/jcp.15r10601.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderRisk of irritabilitySide effectsPsychostimulant medicationPsychostimulant treatmentAmphetamine derivativesPlacebo-controlled trialCommon side effectsStratified subgroup analysisEffects of amphetamineTreatment of childrenDuration of usePsychostimulant classesEligible trialsMedical comorbiditiesHead trialsSubgroup analysisRisk ratioRelative riskSTUDY SELECTIONEffective treatmentDATA SOURCESPubMed searchTrial designStimulant type
2003
Tourette’s syndrome in children
Swain JE, Leckman JF. Tourette’s syndrome in children. Current Treatment Options In Neurology 2003, 5: 299-308. PMID: 12791197, DOI: 10.1007/s11940-003-0036-6.Peer-Reviewed Original ResearchTourette syndromeSide effectsComorbid conditionsPharmacologic agentsCourse of ticsLow-dose neurolepticsRealistic treatment expectationsAvailable pharmacologic agentsAttention deficit hyperactivity disorderBenefits of interventionsCommitted cliniciansDeficit hyperactivity disorderObsessive-compulsive disorderTreatment optionsSuccessful treatmentClinical trialsSomatic treatmentsTreatment responseSpecific symptomsEffective treatmentCommon treatmentTreatment expectationsTic severityTic controlNeurophysiologic basis
2001
A Placebo-Controlled Study of Guanfacine in the Treatment of Children With Tic Disorders and Attention Deficit Hyperactivity Disorder
Scahill L, Chappell PB, Kim YS, Schultz RT, Katsovich L, Shepherd E, Arnsten AF, Cohen DJ, Leckman JF. A Placebo-Controlled Study of Guanfacine in the Treatment of Children With Tic Disorders and Attention Deficit Hyperactivity Disorder. American Journal Of Psychiatry 2001, 158: 1067-1074. PMID: 11431228, DOI: 10.1176/appi.ajp.158.7.1067.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderWeeks of treatmentPlacebo groupTic disordersGuanfacine groupDeficit hyperactivity disorderClinical Global Improvement ScaleHyperactivity disorderSafety of guanfacineGlobal Improvement ScaleDouble-blind conditionsTreatment of childrenMedication-free subjectsDose adjustmentBlood pressureADHD Rating ScaleDisorders ClinicWeek 4Mean improvementEffective treatmentImprovement ScaleGuanfacinePlaceboTic severityContinuous Performance Test