2023
HERV1-env Induces Unfolded Protein Response Activation in Autoimmune Liver Disease: A Potential Mechanism for Regulatory T Cell Dysfunction.
Subramanian K, Paul S, Libby A, Patterson J, Arterbery A, Knight J, Castaldi C, Wang G, Avitzur Y, Martinez M, Lobritto S, Deng Y, Geliang G, Kroemer A, Fishbein T, Mason A, Dominguez-Villar M, Mariappan M, Ekong U. HERV1-env Induces Unfolded Protein Response Activation in Autoimmune Liver Disease: A Potential Mechanism for Regulatory T Cell Dysfunction. The Journal Of Immunology 2023, 210: 732-744. PMID: 36722941, PMCID: PMC10691554, DOI: 10.4049/jimmunol.2100186.Peer-Reviewed Original ResearchConceptsAutoimmune hepatitisDe novo autoimmune hepatitisRegulatory T cell dysfunctionUnfolded protein responseNovo autoimmune hepatitisTregs of patientsAutoimmune liver diseaseIL-17A productionRegulatory T cellsT cell dysfunctionTreg suppressive functionExpression of RORCER stressEndoplasmic reticulum stressTreg plasticityLiver diseaseCell dysfunctionProtein response activationT cellsUnfolded protein response activationSuppressive functionIncreased expressionEffector propertiesReticulum stressPotential mechanisms
2020
HERV1-env dependent unfolded protein response activation is a potential initiator of autoreactivity in autoimmune liver disease
Ekong U, Yao J, Knight J, Mehta S, Avitzur Y, Martinez M, Lobritto S, Mason A. HERV1-env dependent unfolded protein response activation is a potential initiator of autoreactivity in autoimmune liver disease. The Journal Of Immunology 2020, 204: 224.7-224.7. DOI: 10.4049/jimmunol.204.supp.224.7.Peer-Reviewed Original ResearchRegulatory T cellsProtein response activationT cellsUnfolded protein response activationT cell suppressive functionRegulatory T cell suppressive function