2018
BDNF Val66Met polymorphism and posttraumatic stress symptoms in U.S. military veterans: Protective effect of physical exercise
Pitts BL, Whealin JM, Harpaz-Rotem I, Duman RS, Krystal JH, Southwick SM, Pietrzak RH. BDNF Val66Met polymorphism and posttraumatic stress symptoms in U.S. military veterans: Protective effect of physical exercise. Psychoneuroendocrinology 2018, 100: 198-202. PMID: 30388593, DOI: 10.1016/j.psyneuen.2018.10.011.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmino Acid SubstitutionBrain-Derived Neurotrophic FactorCase-Control StudiesExerciseFemaleHumansMaleMethionineMiddle AgedMilitary PersonnelPolymorphism, Single NucleotideProtective FactorsResilience, PsychologicalSeverity of Illness IndexStress Disorders, Post-TraumaticUnited StatesValineVeteransConceptsMet allele carriersBDNF Val66Met polymorphismAllele carriersVal66Met polymorphismPhysical exerciseGreater severityPTSD symptomsU.S. military veteransTrauma burdenBrain-derived neurotrophic factor (BDNF) Val66Met polymorphismPast-month PTSD symptomsNeurotrophic factor Val66Met polymorphismMilitary veteransLifetime trauma burdenHigh trauma burdenVal/ValAdrenal (HPA) axis reactivityPosttraumatic stress disorder (PTSD) symptomsBDNF releaseCurrent PTSD symptomsProtective effectRe-experiencing symptomsAxis reactivityPosttraumatic stress symptomsSymptoms
2016
Co-occurring aggression and suicide attempt among veterans entering residential treatment for PTSD: The role of PTSD symptom clusters and alcohol misuse
Watkins LE, Sippel LM, Pietrzak RH, Hoff R, Harpaz-Rotem I. Co-occurring aggression and suicide attempt among veterans entering residential treatment for PTSD: The role of PTSD symptom clusters and alcohol misuse. Journal Of Psychiatric Research 2016, 87: 8-14. PMID: 27984702, DOI: 10.1016/j.jpsychires.2016.12.009.Peer-Reviewed Original ResearchConceptsSuicide attemptsAlcohol misuseU.S. veteransSymptom clustersPTSD symptom clustersVeterans Health Administration sitesSerious public health concernPTSD re-experiencing symptomsResidential treatmentDysphoric arousal symptomsPublic health concernCo-occurring aggressionLogistic regression modelsMultinomial logistic regression modelsPosttraumatic stress disorder (PTSD) symptom clustersRisk factorsRe-experiencing symptomsCorrelates of aggressionAdministration siteHealth concernMisuse symptomsSymptomsArousal symptomsTreatment planningVeteransInitiation of pharmacotherapy for post-traumatic stress disorder among veterans from Iraq and Afghanistan: a dimensional, symptom cluster approach
Harpaz-Rotem I, Rosenheck R, Mohamed S, Pietrzak R, Hoff R. Initiation of pharmacotherapy for post-traumatic stress disorder among veterans from Iraq and Afghanistan: a dimensional, symptom cluster approach. BJPsych Open 2016, 2: 286-293. PMID: 27703791, PMCID: PMC5016711, DOI: 10.1192/bjpo.bp.115.002451.Peer-Reviewed Original ResearchPost-traumatic stress disorderAnxiolytics/sedatives/hypnoticsPTSD diagnosisUS Veterans Health AdministrationPhenotypic presentationInitiation of pharmacotherapyPrescription of antidepressantsSedative/hypnoticsVeterans Health AdministrationHeterogeneous phenotypic presentationsMilitary-related post-traumatic stress disorderHypnotic prescriptionsMedication classesPrescribing patternsFirst prescriptionMultivariable analysisPharmacological treatmentClinical guidelinesInitial episodeUS veteransPTSD symptom clustersRe-experiencing symptomsSleep difficultiesHealth AdministrationSymptom clusters
2014
Determinants of Prospective Engagement in Mental Health Treatment Among Symptomatic Iraq/Afghanistan Veterans
Harpaz-Rotem I, Rosenheck RA, Pietrzak RH, Southwick SM. Determinants of Prospective Engagement in Mental Health Treatment Among Symptomatic Iraq/Afghanistan Veterans. The Journal Of Nervous And Mental Disease 2014, 202: 97-104. PMID: 24469520, DOI: 10.1097/nmd.0000000000000078.Peer-Reviewed Original ResearchConceptsMental health treatmentPosttraumatic stress disorderIraq/Afghanistan veteransHealth treatmentAfghanistan veteransSymptomatic veteransMental health visitsMental health screeningMental health statusMental health servicesHealth visitsHealth screeningService utilizationRe-experiencing symptomsDepressive symptomsHealth statusHealth servicesPsychosocial determinantsStress disorderSymptomsVeteransTreatmentConsistent determinantsNumbing symptomsProspective engagement