2020
Evaluating the clinical effectiveness and safety of various HER2-targeted regimens after prior taxane/trastuzumab in patients with previously treated, unresectable, or metastatic HER2-positive breast cancer: a systematic review and network meta-analysis
Paracha N, Reyes A, Diéras V, Krop I, Pivot X, Urruticoechea A. Evaluating the clinical effectiveness and safety of various HER2-targeted regimens after prior taxane/trastuzumab in patients with previously treated, unresectable, or metastatic HER2-positive breast cancer: a systematic review and network meta-analysis. Breast Cancer Research And Treatment 2020, 180: 597-609. PMID: 32100144, PMCID: PMC7103014, DOI: 10.1007/s10549-020-05577-7.Peer-Reviewed Original ResearchConceptsMetastatic HER2-positive breast cancerHER2-positive breast cancerOverall response rateProgression-free survivalT-DM1Breast cancerHazard ratioOverall survivalHead trial dataElevated liver transaminasesGastrointestinal side effectsTrial of treatmentAbsence of headRandom-effects NMAAdjuvant therapyEfficacy outcomesLiver transaminasesSafety endpointTolerability profileAdverse eventsEarly relapseMethodsSystematic reviewClinical effectivenessTrastuzumab emtansineConclusionsThe efficacy
2019
O1-8-4 [Encore] Dose justification for [fam-] trastuzumab deruxtecan (DS-8201a) in HER2-positive breast cancer
Takahashi S, Modi S, Tsurutani J, Krop I, Iwata H, Wada R, Yin O, Garimella T, Sugihara M, Zhang L, Lee C, Saito K, Kawasaki Y, Yver A, Tamura K. O1-8-4 [Encore] Dose justification for [fam-] trastuzumab deruxtecan (DS-8201a) in HER2-positive breast cancer. Annals Of Oncology 2019, 30: vi84. DOI: 10.1093/annonc/mdz339.009.Peer-Reviewed Original ResearchObjective response rateInterstitial lung diseaseTrastuzumab deruxtecanOngoing phase 1 studiesImproved progression-free survivalCox proportional hazard modelingHER2-positive breast cancerBenefit/risk profileLogistic regressionProgression-free survivalPhase 1 studyProportional hazard modelingPopulation PK modelDose-finding stageIndividual PK parametersAvailable PK dataILD riskSafety endpointLung diseasePPK modelBC subjectsBreast cancerDose justificationPK parametersPK data