2017
Trastuzumab emtansine versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer (EMILIA): a descriptive analysis of final overall survival results from a randomised, open-label, phase 3 trial
Diéras V, Miles D, Verma S, Pegram M, Welslau M, Baselga J, Krop IE, Blackwell K, Hoersch S, Xu J, Green M, Gianni L. Trastuzumab emtansine versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer (EMILIA): a descriptive analysis of final overall survival results from a randomised, open-label, phase 3 trial. The Lancet Oncology 2017, 18: 732-742. PMID: 28526536, PMCID: PMC5531181, DOI: 10.1016/s1470-2045(17)30312-1.Peer-Reviewed Original ResearchMeSH KeywordsAdo-Trastuzumab EmtansineAdultAgedAged, 80 and overAnemiaAntibodies, Monoclonal, HumanizedAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsAspartate AminotransferasesBreast NeoplasmsBreast Neoplasms, MaleBridged-Ring CompoundsCapecitabineDiarrheaDisease-Free SurvivalFemaleHand-Foot SyndromeHumansLapatinibMaleMaytansineMiddle AgedQuinazolinesReceptor, ErbB-2Response Evaluation Criteria in Solid TumorsRetreatmentSurvival RateTaxoidsThrombocytopeniaTrastuzumabVomitingYoung AdultConceptsWorse adverse eventsMetastatic breast cancerHER2-positive metastatic breast cancerInterim overall survival analysisProgression-free survivalOverall survival dataTrastuzumab emtansineOverall survivalAdverse eventsOverall survival analysisBreast cancerGrade 3Safety profileHER2-positive advanced breast cancerSurvival analysisFinal overall survival dataFinal overall survival resultsPalmar-plantar erythrodysaesthesia syndromeCoprimary efficacy endpointsFinal overall survivalPrevious chemotherapy regimensMedian overall survivalAdvanced breast cancerPhase 3 trialStudy drug discontinuation
2014
Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): a randomised, open-label, phase 3 trial
Krop IE, Kim SB, González-Martín A, LoRusso PM, Ferrero JM, Smitt M, Yu R, Leung AC, Wildiers H, collaborators O. Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): a randomised, open-label, phase 3 trial. The Lancet Oncology 2014, 15: 689-699. PMID: 24793816, DOI: 10.1016/s1470-2045(14)70178-0.Peer-Reviewed Original ResearchConceptsHER2-positive advanced breast cancerPhysician's choice groupWorse adverse eventsAdvanced breast cancerProgression-free survivalInterim overall survival analysisPhase 3 trialTrastuzumab emtansineAdverse eventsOverall survival analysisBreast cancerPhysician's choiceGrade 3Investigator-assessed progression-free survivalSurvival analysisBlock randomisation schemeCytotoxic agent DM1Previous taxane therapySerious adverse eventsWeb response systemMetastatic breast cancerEffective therapeutic optionPopulation of patientsFinal PFS analysisChoice group