2024
Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains
Zhu B, Park J, Coffey S, Russo A, Hsu I, Wang J, Su C, Chang R, Lam T, Gopal P, Ginsberg S, Zhao H, Hafler D, Chandra S, Zhang L. Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains. Science Translational Medicine 2024, 16: eabo1997. PMID: 39475571, DOI: 10.1126/scitranslmed.abo1997.Peer-Reviewed Original ResearchConceptsProteomic analysisAlzheimer's diseasePrefrontal cortexBrain cell typesGenetics of PDParkinson's diseaseCell-cell interactionsChaperone expressionSingle-nucleus transcriptomesExpressed genesTranscriptional changesPostmortem human brainPostmortem brain tissueDiseased brainSynaptic proteinsSingle-cellDown-regulationBrain cell populationsBrain regionsCell typesNeurodegenerative disordersLate-stage PDParkinson's disease brainsDisease etiologyNeuronal vulnerability
2019
Reduction of AHI1 in the serum of Taiwanese with probable Alzheimer’s disease
Sheu JJ, Yang LY, Sanotra MR, Wang ST, Lu HT, Kam RSY, Hsu IU, Kao SH, Lee CK, Shieh JC, Lin YF. Reduction of AHI1 in the serum of Taiwanese with probable Alzheimer’s disease. Clinical Biochemistry 2019, 76: 24-30. PMID: 31786207, DOI: 10.1016/j.clinbiochem.2019.11.011.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAD seraAD patientsEarly diagnosisAD model mouse brainsC-terminal APP fragmentsMini-Mental State Examination scoreSerum samplesHealthy control subjectsState Examination scoreBlood-based biomarkersModel mouse brainProbable Alzheimer's diseaseAge-dependent mannerGood diagnostic performanceHC seraControl subjectsAPP fragmentsAD biomarkersMouse brainYounger ageAD diagnosisNeuronal cellsWestern blottingDisease
2018
Elevated IgM against Nε-(Carboxyethyl)lysine-modified Apolipoprotein A1 peptide 141–147 in Taiwanese with Alzheimer's disease
Lin CY, Sheu JJ, Tsai IS, Wang ST, Yang LY, Hsu IU, Chang HW, Lee HM, Kao SH, Lee CK, Chen CH, Lin YF. Elevated IgM against Nε-(Carboxyethyl)lysine-modified Apolipoprotein A1 peptide 141–147 in Taiwanese with Alzheimer's disease. Clinical Biochemistry 2018, 56: 75-82. PMID: 29680706, DOI: 10.1016/j.clinbiochem.2018.04.009.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAntibody SpecificityApolipoprotein A-IAutoantibodiesAutoimmunityBiomarkersCase-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleGlycation End Products, AdvancedHumansImmunoglobulin MLysineMalePeptide FragmentsProtein Processing, Post-TranslationalPsychiatric Status Rating ScalesROC CurveTaiwanUp-RegulationConceptsAdvanced glycation end productsSpecific advanced glycation end productsAlzheimer's diseaseMini-Mental State Examination scoreMental State Examination scoreEarly AD markersEarly AD pathologyState Examination scoreEarly disease statesGlycation end productsRelated autoantibodiesAD markersIgM levelsAD pathologyElevated IgMAD seraAD patientsDisease progressionAD biomarkersApolipoprotein A1IgMAutoantibodiesApoA1Serum samplesWestern blotting