2020
Stac protein regulates release of neuropeptides
Hsu IU, Linsley JW, Zhang X, Varineau JE, Berkhoudt DA, Reid LE, Lum MC, Orzel AM, Leflein A, Xu H, Collins CA, Hume RI, Levitan ES, Kuwada JY. Stac protein regulates release of neuropeptides. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 29914-29924. PMID: 33168737, PMCID: PMC7703553, DOI: 10.1073/pnas.2009224117.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedBehavior Observation TechniquesBehavior, AnimalCalcium ChannelsDrosophila melanogasterDrosophila ProteinsFemaleIntracellular Signaling Peptides and ProteinsIntravital MicroscopyLarvaMaleModels, AnimalMotor NeuronsMuscle, SkeletalNeuromuscular JunctionNeuropeptidesOptical ImagingPatch-Clamp TechniquesPresynaptic TerminalsConceptsSTAC proteinsRelease of neuropeptidesVertebrate skeletal muscleSubset of neuronsMolecular regulationGenetic manipulationKey regulatorMotor neuronsCytosolic CaNumerous neural functionsSmall familyCentral nervous systemExcitation-contraction couplingGenesSkeletal muscleL-type CaProteinNeuropeptide releaseNervous systemNeural functionDrosophilaNeuropeptidesVertebratesNeuronsRegulator
2017
Transport of the alpha subunit of the voltage gated L‐type calcium channel through the sarcoplasmic reticulum occurs prior to localization to triads and requires the beta subunit but not Stac3 in skeletal muscles
Linsley JW, Hsu I, Wang W, Kuwada JY. Transport of the alpha subunit of the voltage gated L‐type calcium channel through the sarcoplasmic reticulum occurs prior to localization to triads and requires the beta subunit but not Stac3 in skeletal muscles. Traffic 2017, 18: 622-632. PMID: 28697281, PMCID: PMC5569907, DOI: 10.1111/tra.12502.Peer-Reviewed Original ResearchConceptsEC couplingL-type calcium channelsSkeletal muscleL-type voltageExcitation-contraction couplingCongenital myopathyCalcium channelsLongitudinal SRSarcoplasmic reticulumDHPRMembrane depolarizationMuscle fibersTubule membranesMuscleSR membranesAlpha subunitSarcoplasmic reticulum membranesDynamic imagingBeta subunitMembrane voltageTriadPrecise localizationTherapyMyopathy