2017
An Empirical Study for Impacts of Measurement Errors on EHR based Association Studies.
Duan R, Cao M, Wu Y, Huang J, Denny J, Xu H, Chen Y. An Empirical Study for Impacts of Measurement Errors on EHR based Association Studies. AMIA Annual Symposium Proceedings 2017, 2016: 1764-1773. PMID: 28269935, PMCID: PMC5333313.Peer-Reviewed Original Research
2016
CD-REST: a system for extracting chemical-induced disease relation in literature
Xu J, Wu Y, Zhang Y, Wang J, Lee H, Xu H. CD-REST: a system for extracting chemical-induced disease relation in literature. Database 2016, 2016: baw036. PMID: 27016700, PMCID: PMC4808251, DOI: 10.1093/database/baw036.Peer-Reviewed Original ResearchConceptsChemical-induced disease relationsWeb servicesBiomedical literatureEntity recognitionMachine learning-based approachLearning-based approachHTTP POST requestRelation extraction systemVector space modelConditional Random FieldsSupport vector machineRelation extraction moduleVast biomedical literatureDisease relation extractionChemical-induced disease relation extractionExtraction moduleDisease relationsAutomatic extractionEnd systemPOST requestRelation extractionNormalization moduleVector machineBioCreative VDemonstration system
2015
A comparative study of disease genes and drug targets in the human protein interactome
Sun J, Zhu K, Zheng W, Xu H. A comparative study of disease genes and drug targets in the human protein interactome. BMC Bioinformatics 2015, 16: s1. PMID: 25861037, PMCID: PMC4402590, DOI: 10.1186/1471-2105-16-s5-s1.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesDisease genesDrug targetsHuman protein-coding genesHuman protein-protein interaction networkProtein-protein interaction networkProtein-coding genesHuman protein interactomeComplex diseasesNovel drug targetsProtein interactomeAnatomical Therapeutic Chemical (ATC) classificationInteraction networksDisease proteinAssociation studiesGenesDisease categoriesInteractomeProteinMajor disease categoriesDifferent disease categoriesFirst comprehensive comparisonTargetTreatment efficacyHigh betweenness
2007
Automated Acquisition of Disease–Drug Knowledge from Biomedical and Clinical Documents: An Initial Study
Chen E, Hripcsak G, Xu H, Markatou M, Friedman C. Automated Acquisition of Disease–Drug Knowledge from Biomedical and Clinical Documents: An Initial Study. Journal Of The American Medical Informatics Association 2007, 15: 87-98. PMID: 17947625, PMCID: PMC2274872, DOI: 10.1197/jamia.m2401.Peer-Reviewed Original Research