Featured Publications
Leveraging LD eigenvalue regression to improve the estimation of SNP heritability and confounding inflation
Song S, Jiang W, Zhang Y, Hou L, Zhao H. Leveraging LD eigenvalue regression to improve the estimation of SNP heritability and confounding inflation. American Journal Of Human Genetics 2022, 109: 802-811. PMID: 35421325, PMCID: PMC9118121, DOI: 10.1016/j.ajhg.2022.03.013.Peer-Reviewed Original ResearchConceptsLinkage disequilibrium score regressionComplex traitsSingle nucleotide polymorphismsSNP heritabilityGenome-wide association studiesDisequilibrium score regressionHigh-throughput technologiesHeritable phenotypesAssociation studiesGenetic studiesCryptic relatednessLD informationScore regressionHeritabilityGenetic contributionHeritability estimationPopulation stratificationDisease mechanismsTraitsLD matrixOnly summary statisticsUK BiobankPolygenicitySummary statisticsRelatedness
2005
Integrating mRNA Decay Information into Co-Regulation Study
Chen L, Zhao H. Integrating mRNA Decay Information into Co-Regulation Study. Journal Of Computer Science And Technology 2005, 20: 434-438. DOI: 10.1007/s11390-005-0434-1.Peer-Reviewed Original ResearchMRNA decay ratesTranscript amountsTranscription rateBioinformatics analysisTranscriptional regulatory networksCo-regulated genesRelative transcript amountsMRNA degradation ratesHigh-throughput technologiesGene regulationGenomic signalsRegulatory networksDifferent genesGene clusteringMRNA synthesisMRNA transcriptsDownstream analysisGenesDNAMotifSimilarity analysisTranscriptsRegulationIdentification