2020
Depth importance in precision medicine (DIPM): a tree- and forest-based method for right-censored survival outcomes
Chen V, Zhang H. Depth importance in precision medicine (DIPM): a tree- and forest-based method for right-censored survival outcomes. Biostatistics 2020, 23: 157-172. PMID: 32424406, PMCID: PMC8759439, DOI: 10.1093/biostatistics/kxaa021.Peer-Reviewed Original Research
2018
Subtype classification and heterogeneous prognosis model construction in precision medicine
You N, He S, Wang X, Zhu J, Zhang H. Subtype classification and heterogeneous prognosis model construction in precision medicine. Biometrics 2018, 74: 814-822. PMID: 29359319, DOI: 10.1111/biom.12843.Peer-Reviewed Original ResearchConceptsRegularization regressionVariable selectionHigh-dimensional predictorsNecessary statistical methodsVariable selection methodsExpectation-maximization algorithmOracle propertyPenalty parameterSemiparametric modelStatistical methodsParametric modelNumerical calculationsProper choiceModel constructionSelection methodGene expression datasetsModelEstimatorSubtype-specific risk factorsRegularizerSurvival probabilityHigh-throughput technologiesExpression datasetsAlgorithmSimulations
2015
Subgroup Identification in Personalized Treatment of Alcohol Dependence
Hou J, Seneviratne C, Su X, Taylor J, Johnson B, Wang XQ, Zhang H, Kranzler HR, Kang J, Liu L. Subgroup Identification in Personalized Treatment of Alcohol Dependence. Alcohol Clinical And Experimental Research 2015, 39: 1253-1259. PMID: 26031187, PMCID: PMC4491003, DOI: 10.1111/acer.12759.Peer-Reviewed Original Research