2024
The effect of improved metabolic syndrome parameters on live birth
Spitzer T, Diamond M, Wild R, Legro R, Zhang H, Sun F, Ling S, Santoro N. The effect of improved metabolic syndrome parameters on live birth. Fertility And Sterility 2024, 122: 373-375. PMID: 38641159, DOI: 10.1016/j.fertnstert.2024.04.020.Peer-Reviewed Original ResearchMetabolic syndrome Z-scoreLifestyle interventionLive birthsLive birth rateMetabolic syndrome parametersZ-scoreMetabolic syndromeUnexplained infertilityIntrauterine inseminationOvarian stimulationSyndrome parametersMetabolic parametersObese WomenBirth outcomesLive birth outcomesIntervention phaseImprove metabolic syndromeSecondary analysisFisher's exact testStudy participantsZ-score differenceLifestyle modificationStudent's t-testBirth rateLogistic regressionFibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) – protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids
Al-Hendy A, Segars J, Taylor H, González F, Siblini H, Zamah M, Alkelani H, Singh B, Flores V, Christman G, Johnson J, Huang H, Zhang H. Fibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) – protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids. BMJ Open 2024, 14: e078989. PMID: 38216200, PMCID: PMC10806662, DOI: 10.1136/bmjopen-2023-078989.Peer-Reviewed Original ResearchConceptsUnexplained infertilityIntrauterine inseminationInstitutional review boardCumulative live birth rateUterine fibroidsLive birth rateCause of infertilityFood and Drug AdminstrationGonadotropin hormone-releasing hormoneGreen tea extractDouble-blind clinical trialNon-surgical treatment optionsTimed intrauterine inseminationUterine fibroid sizeOvarian stimulationQuality of Life Questionnaire scoresHormone-releasing hormoneLocal institutional review boardInfertility treatmentNational Institute of Child HealthInstitute of Child HealthMiscarriage rateBirth rateReproductive-age womenEndometrial quality
2023
ASSOCIATION OF FOLLICULAR PHASE LENGTH (FPL) AND EARLY PREGNANCY LOSS (EPL) IN WOMEN WITH UNEXPLAINED INFERTILITY UNDERGOING OVARIAN STIMULATION WITH INTRAUTERINE INSEMINATION (OS-IUI) CYCLES
Hosseinzadeh P, Schone E, Peck J, Craig L, Zhang H, Legro R, Diamond M, Santoro N, Hansen K. ASSOCIATION OF FOLLICULAR PHASE LENGTH (FPL) AND EARLY PREGNANCY LOSS (EPL) IN WOMEN WITH UNEXPLAINED INFERTILITY UNDERGOING OVARIAN STIMULATION WITH INTRAUTERINE INSEMINATION (OS-IUI) CYCLES. Fertility And Sterility 2023, 120: e170-e171. DOI: 10.1016/j.fertnstert.2023.08.507.Peer-Reviewed Original ResearchModerate and increased physical activity is not detrimental to live birth rates among women with unexplained infertility and obesity
Vitek W, Sun F, Cardozo E, Hoeger K, Hansen K, Santoro N, Zhang H, Legro R. Moderate and increased physical activity is not detrimental to live birth rates among women with unexplained infertility and obesity. F&S Reports 2023, 4: 308-312. PMID: 37719091, PMCID: PMC10504528, DOI: 10.1016/j.xfre.2023.06.004.Peer-Reviewed Original ResearchLive birth rateSteps/dayPhysical activityInfertility trialsLifestyle modificationUnexplained infertilityObese womenBirth rateClomiphene citrate treatmentUS fertility centersClinical pregnancy rateLifestyle modification programTime of enrollmentModerate physical activityPhysical activity goalsMiscarriage rateFertility centerIntrauterine inseminationFitbit activity trackerPregnancy rateSecondary analysisCitrate treatmentActivity goalsModification programWomenAssessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women
Siblini H, Al-Hendy A, Segars J, González F, Taylor H, Singh B, Flaminia A, Flores V, Christman G, Huang H, Johnson J, Zhang H. Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women. Nutrients 2023, 15: 320. PMID: 36678191, PMCID: PMC9861948, DOI: 10.3390/nu15020320.Peer-Reviewed Original ResearchConceptsReproductive-aged womenLiver function testsUterine fibroidsUnexplained infertilityClomiphene citrateSerum liver function testsEpigallocatechin gallateSigns of drugSerum folate levelsGreen tea catechinsHepatic safetyPremenopausal womenProspective cohortDaily doseLiver injuryFunction testsTreatment armsLiver toxicityClinical studiesCommon causeFolate levelsEarly safety assessmentInterim analysisNormal rangeUse of EGCG
2020
Short-term weight change and live birth among women with unexplained infertility and polycystic ovary syndrome undergoing ovulation induction
Vitek W, Sun F, Hoeger KM, Santoro N, Diamond MP, Zhang H, Legro RS, Network E, Coutifaris C, Christman G, Robinson R, Brzyski R, Schlaff W, Casson P, Trussell J, Eisenberg E, Lamar C, DePaolo L. Short-term weight change and live birth among women with unexplained infertility and polycystic ovary syndrome undergoing ovulation induction. Fertility And Sterility 2020, 114: 1032-1039. PMID: 33036790, PMCID: PMC7953832, DOI: 10.1016/j.fertnstert.2020.06.002.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeShort-term weight changeUnexplained infertilityLive birth rateOvulation inductionOvary syndromeWeight changeWeight gainCycles of clomipheneBody mass indexMean weight changeBirth rateRandomized trialsMass indexRegular intercourseIntrauterine inseminationTreatment allocationLive birthsMAIN OUTCOMESecondary analysisWomenWeight assessmentBirthSyndromeInfertilityEndometrial thickness after ovarian stimulation with gonadotropin, clomiphene, or letrozole for unexplained infertility, and association with treatment outcomes
Quaas AM, Gavrizi SZ, Peck JD, Diamond MP, Legro RS, Robinson RD, Casson P, Christman GM, Zhang H, Hansen KR, Network E. Endometrial thickness after ovarian stimulation with gonadotropin, clomiphene, or letrozole for unexplained infertility, and association with treatment outcomes. Fertility And Sterility 2020, 115: 213-220. PMID: 32972733, PMCID: PMC7796980, DOI: 10.1016/j.fertnstert.2020.07.030.Peer-Reviewed Original ResearchConceptsLive birth rateEndometrial thicknessUnexplained infertilityOvarian stimulationRisk ratioLive birthsEMT groupHuman chorionic gonadotropin administrationHigher live birth rateIntrauterine insemination treatmentMean endometrial thicknessMultiple Intrauterine GestationsOvarian stimulation medicationChorionic gonadotropin administrationProspective cohort analysisUnadjusted risk ratioAdjusted risk ratioBirth rateOS-IUIThin endometriumIntrauterine gestationGonadotropin administrationStimulation medicationsClinical trialsTreatment outcomesIntrauterine insemination performance characteristics and post-processing total motile sperm count in relation to live birth for couples with unexplained infertility in a randomised, multicentre clinical trial
Hansen KR, Peck JD, Coward RM, Wild RA, Trussell JC, Krawetz SA, Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Santoro N, Zhang H. Intrauterine insemination performance characteristics and post-processing total motile sperm count in relation to live birth for couples with unexplained infertility in a randomised, multicentre clinical trial. Human Reproduction 2020, 35: 1296-1305. PMID: 32432326, PMCID: PMC7316499, DOI: 10.1093/humrep/deaa027.Peer-Reviewed Original ResearchConceptsTotal motile sperm countLive birth rateHigher total motile sperm countUnexplained infertilityMulticentre clinical trialMotile sperm countClinical trialsLive birthsOvarian stimulationHCG injectionBirth ratePatient discomfortSperm countTreatment cyclesSecondary analysisEunice Kennedy Shriver National InstituteSTUDY FUNDING/COMPETINGLive birth successMultiple Intrauterine GestationsDuration of infertilityIUI treatment cyclesLive birth outcomesPARTICIPANTS/MATERIALSROLE OF CHANCEYears of ageOR11-04 Effect of Preconception Intensive vs. Standard Lifestyle Intervention on Birth Outcomes in Obese Women With Unexplained Infertility: A Multicenter Randomized Trial
Legro R, Hansen K, Diamond M, Steiner A, Mersereau J, Sarwer D, Kris-Etherton P, Wild R, Krawetz S, Hoeger K, Usadi R, Johnstone E, Hao H, Eisenberg E, Santoro N, Zhang H. OR11-04 Effect of Preconception Intensive vs. Standard Lifestyle Intervention on Birth Outcomes in Obese Women With Unexplained Infertility: A Multicenter Randomized Trial. Journal Of The Endocrine Society 2020, 4: or11-04. PMCID: PMC7209215, DOI: 10.1210/jendso/bvaa046.2149.Peer-Reviewed Original ResearchStandard lifestyle modificationBetter birth outcomesUnexplained infertilityLive birthsObese womenBirth outcomesPregnancy lossLifestyle modificationLifestyle interventionWeight lossPhysical activityIL groupLow perinatal morbidityMajor pregnancy complicationsPreconception lifestyle interventionStandard lifestyle interventionGI side effectsKey secondary outcomesMulticenter Randomized TrialUse of orlistatMajor congenital anomaliesModerate weight lossPregnancy complication rateEarly pregnancy lossGestational DMPregnancy registry: three-year follow-up of children conceived from letrozole, clomiphene, or gonadotropins
Legro RS, Diamond MP, Coutifaris C, Schlaff WD, Alvero R, Casson P, Christman GM, Rosen RM, Cedars MI, Hansen KR, Robinson R, Baker V, Usadi R, Dodson WC, Estes SJ, Kunselman A, Stetter C, Barnhart KT, Coward RM, Trussell JC, Krawetz SA, Santoro N, Huang H, Zhang H, Eisenberg E, Network R. Pregnancy registry: three-year follow-up of children conceived from letrozole, clomiphene, or gonadotropins. Fertility And Sterility 2020, 113: 1005-1013. PMID: 32386612, PMCID: PMC7376442, DOI: 10.1016/j.fertnstert.2019.12.023.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsChild BehaviorChild DevelopmentChild, PreschoolClomipheneCognitionFemaleFertilityFertility AgentsFollow-Up StudiesGesturesGonadotropinsHumansInfantInfertility, FemaleLetrozoleLive BirthMaleOvulation InductionPolycystic Ovary SyndromePregnancyProspective StudiesRandomized Controlled Trials as TopicRegistriesTreatment OutcomeUnited StatesWeight GainConceptsGN groupMultiple pregnancy rateProspective cohort studyPolycystic ovary syndromeChildren of womenInfertility trialsUnexplained infertilityCohort studyII studyMultiple gestationsOvary syndromeHealth centersInfertility treatmentPregnancy rateInfertility therapyMAIN OUTCOMELTZ groupLetrozoleMacArthur-Bates Communicative Development InventoriesAcademic health centersGonadotropinAbnormal scoresClomipheneCC groupDevelopmental QuestionnaireAndrogenicity and fertility treatment in women with unexplained infertility
Wang ET, Diamond MP, Alvero R, Casson P, Christman GM, Coutifaris C, Hansen KR, Sun F, Legro RS, Robinson RD, Usadi RS, Pisarska MD, Santoro NF, Zhang H, Network I. Androgenicity and fertility treatment in women with unexplained infertility. Fertility And Sterility 2020, 113: 636-641. PMID: 32192596, PMCID: PMC7088440, DOI: 10.1016/j.fertnstert.2019.10.034.Peer-Reviewed Original ResearchConceptsLive birth rateBody mass indexUnexplained infertilityClinical pregnancyMass indexPregnancy lossClinical markersLive birthsAndrogenic activityFree androgen index valuesHigher body mass indexMultivariable logistic regression modelMultiple Intrauterine GestationsNormal uterine cavityHigh waist circumferenceOvarian stimulation treatmentPatent fallopian tubesBirth rateLogistic regression modelsAndrogen markersSerum TTOvarian stimulationRegular mensesInfertility populationIntrauterine gestation
2019
Associations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index
Rios JS, Greenwood EA, Pavone MEG, Cedars MI, Legro RS, Diamond MP, Santoro N, Sun F, Robinson RD, Christman G, Zhang H, Huddleston HG. Associations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index. The Journal Of Clinical Endocrinology & Metabolism 2019, 105: dgz012. PMID: 31586179, PMCID: PMC7024739, DOI: 10.1210/clinem/dgz012.Peer-Reviewed Original ResearchConceptsHomeostasis model assessment-insulin resistancePolycystic ovary syndromeAnti-Mullerian hormoneBody mass indexC-reactive proteinUnexplained infertilityWaist circumferenceOVA groupLipoprotein cholesterolMass indexRelationship of AMHModel assessment-insulin resistanceHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolSite-adjusted modelsAssessment-insulin resistanceAntral follicle countCardio-metabolic healthReproductive-aged womenMultivariable linear regression modelsReproductive-age womenClinical populationsLow-density lipoproteinCardiometabolic agingCardiometabolic indicesFertility Related Quality of Life, Gonadal Function and Erectile Dysfunction in Male Partners of Couples with Unexplained Infertility.
Coward RM, Stetter C, Kunselman A, Trussell JC, Lindgren MC, Alvero RR, Casson P, Christman GM, Coutifaris C, Diamond MP, Hansen KR, Krawetz SA, Legro RS, Robinson RD, Smith JF, Steiner AZ, Wild RA, Zhang H, Santoro N. Fertility Related Quality of Life, Gonadal Function and Erectile Dysfunction in Male Partners of Couples with Unexplained Infertility. Journal Of Urology 2019, 202: 379-384. PMID: 30835629, PMCID: PMC6686175, DOI: 10.1097/ju.0000000000000205.Peer-Reviewed Original ResearchConceptsQuality of lifeLow total testosteroneTotal testosteroneErectile dysfunctionUnexplained infertilityFertiQoL scoresTestosterone levelsSemen parametersLow total testosterone levelsMultivariable logistic regression analysisMale partnersBaseline semen analysisWorse erectile dysfunctionTotal testosterone levelsAbnormal semen qualityPrimary study outcomePHQ-9 scoresBody mass indexMen of couplesLogistic regression analysisInfertility durationMen 59IIEF scorePatient ageSD ageAssociation between testosterone, semen parameters, and live birth in men with unexplained infertility in an intrauterine insemination population
Trussell JC, Coward RM, Santoro N, Stetter C, Kunselman A, Diamond MP, Hansen KR, Krawetz SA, Legro RS, Heisenleder D, Smith J, Steiner A, Wild R, Casson P, Coutifaris C, Alvero RR, Robinson RB, Christman G, Patrizio P, Zhang H, Lindgren MC, Network R. Association between testosterone, semen parameters, and live birth in men with unexplained infertility in an intrauterine insemination population. Fertility And Sterility 2019, 111: 1129-1134. PMID: 30982604, PMCID: PMC6557574, DOI: 10.1016/j.fertnstert.2019.01.034.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersDown-RegulationFemaleFertilityHumansInfertility, MaleInsemination, Artificial, HomologousLive BirthMaleMulticenter Studies as TopicPregnancyPregnancy RateRandomized Controlled Trials as TopicRisk FactorsSperm CountSperm MotilitySpermatogenesisTestosteroneTreatment OutcomeConceptsUnexplained infertilityLow TTMale partnersLive birthsSemen parametersSecondary analysisMultiple Intrauterine GestationsLive birth rateBody mass indexMulticenter clinical trialAbnormal sperm morphologyOvarian stimulationIntrauterine gestationPregnancy outcomesMass indexInfertility clinicClinical trialsMAIN OUTCOMETotal motile spermSemen analysisAbnormal spermatogenesisInfertilityLogistic regressionSperm concentrationSemen volumeLower prevalence of non–cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility
Huang H, Kuang H, Sun F, Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson PR, Christman GM, Hansen KR, Santoro N, Eisenberg E, Zhang H, Network E. Lower prevalence of non–cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility. Fertility And Sterility 2019, 111: 1011-1019.e1. PMID: 30926125, PMCID: PMC6487215, DOI: 10.1016/j.fertnstert.2019.01.020.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeUnexplained infertilityUterine fibroidsLow prevalenceOvary syndromeDifferent body mass index (BMI) groupsBody mass index groupsHigher body mass indexHigher total testosteroneNormal uterine cavityAssessment-insulin resistanceBody mass indexRandomized clinical trialsCurrent alcohol usersPrevalence of womenTotal testosteroneCurrent smokersInfertile womenLarge fibroidsMass indexInfertile patientsInsulin resistanceUterine cavityClinical trialsLower percentage
2018
Weight gain during ovulation induction among women with polycystic ovary syndrome and unexplained infertility
Vitek W, Sun F, Hoeger K, Santoro N, Diamond M, Zhang H, Legro R. Weight gain during ovulation induction among women with polycystic ovary syndrome and unexplained infertility. Fertility And Sterility 2018, 110: e68. DOI: 10.1016/j.fertnstert.2018.07.207.Peer-Reviewed Original ResearchVitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility
Butts SF, Seifer DB, Koelper N, Senapati S, Sammel MD, Hoofnagle AN, Kelly A, Krawetz SA, Santoro N, Zhang H, Diamond MP, Legro RS, Network E. Vitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility. The Journal Of Clinical Endocrinology & Metabolism 2018, 104: 369-378. PMID: 30085176, PMCID: PMC6300410, DOI: 10.1210/jc.2018-00750.Peer-Reviewed Original ResearchConceptsVitamin D deficiencyPolycystic ovary syndromeD deficiencyEarly pregnancy lossOvarian stimulationUnexplained infertilityLive birthsPregnancy lossDiagnosis of PCOSMultiple Intrauterine GestationsOvarian stimulation outcomesRetrospective cohort studyInvestigation of womenBanked seraPPCOS IICohort studyIntrauterine gestationOvary syndromeInfertile womenInfertility diagnosisPregnant subjectsElevated riskImportant treatmentReproductive outcomesTrial dataAllostatic load, a measure of chronic physiological stress, is associated with pregnancy outcomes, but not fertility, among women with unexplained infertility
Barrett ES, Vitek W, Mbowe O, Thurston SW, Legro RS, Alvero R, Baker V, Bates GW, Casson P, Coutifaris C, Eisenberg E, Hansen K, Krawetz S, Robinson R, Rosen M, Usadi R, Zhang H, Santoro N, Diamond M. Allostatic load, a measure of chronic physiological stress, is associated with pregnancy outcomes, but not fertility, among women with unexplained infertility. Human Reproduction 2018, 33: 1757-1766. PMID: 30085177, PMCID: PMC6454470, DOI: 10.1093/humrep/dey261.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesOvarian stimulationPreterm birthPregnancy outcomesLive birthsUnexplained infertilityLipoprotein cholesterolBlood pressureBirth outcomesLow birthweightAllostatic loadSpontaneous abortionReproductive outcomesHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolAL scoreSTUDY FUNDING/COMPETINGChronic physiological stressMulti-variable logistic regression modelAdvanced Reproductive CareMultiple Intrauterine GestationsDiastolic blood pressureNon-pregnant stateSystolic blood pressureType of infertilityLetter to the Editor: “Higher TSH Levels Within the Normal Range Are Associated With Unexplained Infertility”
Diamond MP, Huang H, Gracia C, Santoro N, Zhang H. Letter to the Editor: “Higher TSH Levels Within the Normal Range Are Associated With Unexplained Infertility”. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 3110-3111. PMID: 29889234, PMCID: PMC6692707, DOI: 10.1210/jc.2018-00704.Peer-Reviewed Original ResearchMidluteal Progesterone: A Marker of Treatment Outcomes in Couples With Unexplained Infertility
Hansen KR, Eisenberg E, Baker V, Hill MJ, Chen S, Talken S, Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Santoro N, Zhang H, Wild RA, Network N. Midluteal Progesterone: A Marker of Treatment Outcomes in Couples With Unexplained Infertility. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 2743-2751. PMID: 29767754, PMCID: PMC6276712, DOI: 10.1210/jc.2018-00642.Peer-Reviewed Original ResearchConceptsMidluteal progesterone levelsUnexplained infertilityLive birthsOS-IUIProgesterone levelsPregnancy outcomesClinical trialsTreatment groupsIntrauterine insemination treatmentMultiple Intrauterine GestationsOvarian stimulation medicationSuccessful pregnancy outcomeMulticenter clinical trialLow progesterone levelsMidluteal progesteroneClomiphene citrateOvarian stimulationIntrauterine gestationEndometrial changesPathophysiologic mechanismsGonadotropin treatmentStimulation medicationsProgesterone exposureTreatment outcomesProgesterone concentrations