2018
Subtype Classification and Heterogeneous Prognosis Model Construction in Precision Medicine
You N, He S, Wang X, Zhu J, Zhang H. Subtype Classification and Heterogeneous Prognosis Model Construction in Precision Medicine. Biometrics 2018, 74: 814-822. PMID: 29359319, DOI: 10.1111/biom.12843.Peer-Reviewed Original ResearchConceptsRegularization regressionVariable selectionHigh-dimensional predictorsNecessary statistical methodsVariable selection methodsExpectation-maximization algorithmOracle propertyPenalty parameterSemiparametric modelStatistical methodsParametric modelNumerical calculationsProper choiceModel constructionSelection methodGene expression datasetsModelEstimatorSubtype-specific risk factorsRegularizerSurvival probabilityHigh-throughput technologiesExpression datasetsAlgorithmSimulations
2014
Identifying Genetic Variants for Addiction via Propensity Score Adjusted Generalized Kendall’s Tau
Jiang Y, Li N, Zhang H. Identifying Genetic Variants for Addiction via Propensity Score Adjusted Generalized Kendall’s Tau. Journal Of The American Statistical Association 2014, 109: 905-930. PMID: 25382885, PMCID: PMC4219655, DOI: 10.1080/01621459.2014.901223.Peer-Reviewed Original ResearchGenome-wide association studiesGenetic variantsU-statisticsU-statistic methodNovel genetic variantsGWAS analysisPhenotype-genotype associationsEnvironmental factorsReplicable genetic variantsAssociation studiesSemiparametric methodAssociation analysisStatistical methodsStudy of AddictionParametric methodsGene-environment interactionsParametric estimatesInverse probability weightingSimulation resultsProbability weightingNull hypothesisVariantsKendall's tauGeneticsTraits
2007
A score test for linkage analysis of ordinal traits based on IBD sharing
Feng R, Zhang H. A score test for linkage analysis of ordinal traits based on IBD sharing. Biostatistics 2007, 9: 114-127. PMID: 17519391, DOI: 10.1093/biostatistics/kxm016.Peer-Reviewed Original Research