2024
Variant Selection and Aggregation of Genetic Association Studies in Precision Medicine
Hu J, Wang S, Zhang H. Variant Selection and Aggregation of Genetic Association Studies in Precision Medicine. ICSA Book Series In Statistics 2024, 423-451. DOI: 10.1007/978-3-031-50690-1_17.Peer-Reviewed Original ResearchAssociation studiesGenetic association studiesPrecision medicineTests of associationHeterogeneous drug responsesDisease risk predictionVariant identificationSignal variantsControl of type I errorDisease riskDrug responseGenomic profilingType I errorRisk predictionGenetic biomarkersVariantsPharmaceutical interventionsMarginal testsAssociation methodAssociationMedicineInterventionIdentificationReplicationDisease
2020
Supervariants identification for breast cancer
Hu J, Li T, Wang S, Zhang H. Supervariants identification for breast cancer. Genetic Epidemiology 2020, 44: 934-947. PMID: 32808324, PMCID: PMC7924970, DOI: 10.1002/gepi.22350.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesCombination of allelesRare variantsNovel lociChromosome 2UK Biobank databaseChromosome 1Multiple lociAssociation studiesLociComplex diseasesGenesBiobank databaseAssociation methodGenomeVariantsTens of thousandsAllelesPolymorphismNovel resultsSignalsClassic conceptIdentification
2008
Modelling gene regulation networks via multivariate adaptive splines.
Chen X, Zhang H. Modelling gene regulation networks via multivariate adaptive splines. Cancer Genomics & Proteomics 2008, 5: 55-62. PMID: 18359980, PMCID: PMC3159687.Peer-Reviewed Original ResearchConceptsRegulatory networksRegulation networkMultivariate adaptive splinesTranscriptional regulation networkTranscriptional regulatory networksGene regulation networksDozens of genomesTranscriptome reprogrammingGene expression time series dataRegulatory motifsHuman genomeTranscription factorsPutative motifsRegulatory functionsRegulatory roleEukaryotesMotifGenomePhysiological conditionsReprogrammingYeastAdaptive splinesIdentification