1986
Hemodynamic Effects of High Frequency Ventilation in Surfactant-Treated Preterm Lambs
Oguchi K, Baylen B, Ikegami M, Jacobs H, Berry D, Jobe A, Emmanouilides G. Hemodynamic Effects of High Frequency Ventilation in Surfactant-Treated Preterm Lambs. Neonatology 1986, 49: 21-28. PMID: 3753885, DOI: 10.1159/000242505.Peer-Reviewed Original ResearchConceptsHigh-frequency ventilationConventional ventilationHemodynamic effectsDuctus arteriosusPreterm lambsFrequency ventilationSame mean airway pressureLV end-diastolic volumeRight ductal shuntSurfactant-treated lambsMean airway pressureDeleterious hemodynamic effectsOrgan blood flowMin of ageEnd-diastolic volumeBlood gas valuesDays gestational ageLV stroke volumeBlood flow measurementsComparable ventilationDuctal shuntAirway pressureDuctal occlusionHemodynamic statusArterial pressure
1985
Normalization of Arterial Blood Gases after Treatment of Surfactant-Deficient Lambs with Tween 201–3
Jacobs H, Berry D, Duane G, Ikegami M, Jobe A, Jones S. Normalization of Arterial Blood Gases after Treatment of Surfactant-Deficient Lambs with Tween 201–3. American Journal Of Respiratory And Critical Care Medicine 1985, 132: 1313-8. PMID: 3935021, DOI: 10.1164/arrd.1985.132.6.1313.Peer-Reviewed Original ResearchConceptsPeak inspiratory pressurePulmonary surfactantAdequate ventilationMinimal surface tensionArterial blood gasesNormal lung functionMin of ageRespiratory failureLung functionLung complianceInspiratory pressureBlood gasesInfant ventilatorDays gestationAlveolar washControl animalsControl lambsPoor oxygenationSurfactant treatmentGas exchangeTreatmentVentilationLambsGestationVentilatorAccumulation of Alveolar Surfactant Following Delivery and Ventilation of Premature Lambs
Jacobs H, Jobe A, Ikegami M, Jones S. Accumulation of Alveolar Surfactant Following Delivery and Ventilation of Premature Lambs. Experimental Lung Research 1985, 8: 125-140. PMID: 3839748, DOI: 10.3109/01902148509057517.Peer-Reviewed Original ResearchConceptsAlveolar washTreatment doseAlveolar surfactantMean gestational ageArterial blood gasPeak inspiratory pressureMin of ageSurfactant pool sizeAlveolar surfactant accumulationPhosphatidylcholine specific activityCesarean sectionPremature lambsGestational agePremature lungInspiratory pressureIntratracheal administrationBlood gasTrace doseDilution techniqueDoseAgeAirwayPool sizeBirthAccumulation of surfactant
1982
Premature Lambs Rescued from Respiratory Failure with Natural Surfactant: Clinical and Biophysical Correlates
Jacobs H, Jobe A, Ikegami M, Glatz T, Jones S, Barajas L. Premature Lambs Rescued from Respiratory Failure with Natural Surfactant: Clinical and Biophysical Correlates. Pediatric Research 1982, 16: 424-429. PMID: 6920645, DOI: 10.1203/00006450-198206000-00005.Peer-Reviewed Original ResearchConceptsRespiratory failureDistal airwaysRespiratory distress syndromeMin of ageDays gestational agePressure-volume curvesClinical deteriorationClinical responsePremature lambsDistress syndromePosttreatment groupGestational ageMechanical ventilationProgressive dilatationUntreated lungsPremature babiesTracheal instillationBlood gasAlveolar washSurfactant replacementBody weightLung structureAirwayMinimum surface tensionHistologic measurements