2018
NACSELD acute‐on‐chronic liver failure (NACSELD‐ACLF) score predicts 30‐day survival in hospitalized patients with cirrhosis
O'Leary JG, Reddy KR, Garcia‐Tsao G, Biggins SW, Wong F, Fallon MB, Subramanian RM, Kamath PS, Thuluvath P, Vargas HE, Maliakkal B, Tandon P, Lai J, Thacker LR, Bajaj JS. NACSELD acute‐on‐chronic liver failure (NACSELD‐ACLF) score predicts 30‐day survival in hospitalized patients with cirrhosis. Hepatology 2018, 67: 2367-2374. PMID: 29315693, DOI: 10.1002/hep.29773.Peer-Reviewed Original ResearchConceptsEnd-stage liver disease (MELD) scoreLiver Disease scoreOrgan failureHospitalized patientsBedside toolDisease scoreChronic liver failure scoreTertiary-care hepatology centersWhite blood cell countAlcohol-induced cirrhosisExtrahepatic organ failureMedian Child scoreReliable bedside toolChronic liver failureDiagnosis of cirrhosisBlood cell countRisk of mortalityPresence of infectionSimple bedside toolNorth American ConsortiumHepatology centersNACSELD-ACLFSeparate multicenterUninfected patientsProspective cohort
1988
Distal splenorenal vs. portal‐systemic shunts after hemorrhage from varices: A randomized controlled trial
Grace N, Conn H, Resnick R, Groszmann R, Atterbury C, Wright S, Gusberg R, Vollman R, Garcia‐Tsao G, Fisher R, O'Hara E, McDermott W, Maselli J, Widrich W, Matloff D, Horst D, Banks N, Alberts J. Distal splenorenal vs. portal‐systemic shunts after hemorrhage from varices: A randomized controlled trial. Hepatology 1988, 8: 1475-1481. PMID: 3056820, DOI: 10.1002/hep.1840080602.Peer-Reviewed Original ResearchConceptsDistal splenorenal shunt groupPortal-systemic shuntsDistal splenorenal shuntShunt groupSplenorenal shuntVariceal hemorrhageMajor variceal hemorrhageReasonable operative riskRecurrent variceal hemorrhageGroup of patientsPortal venous flowShunt patientsAngiographic evidenceLate mortalityOperative mortalityCirrhotic patientsLiver groupOperative riskRenal veinInferior venaAngiographic demonstrationVenous flowPatientsTotal mortalityShuntColchicine in the Treatment of Cirrhosis of the Liver
Kershenobich D, Vargas F, Garcia-Tsao G, Tamayo R, Gent M, Rojkind M. Colchicine in the Treatment of Cirrhosis of the Liver. New England Journal Of Medicine 1988, 318: 1709-1713. PMID: 3287167, DOI: 10.1056/nejm198806303182602.Peer-Reviewed Original ResearchConceptsTreatment of cirrhosisPlacebo groupHistologic improvementColchicine groupSurvival rateMinimal portal fibrosisPlacebo-controlled trialPercent of patientsUse of colchicineAlcoholic cirrhosisOverall survivalPortal fibrosisMore biopsiesHepatic cirrhosisLiver biopsyPosthepatitic cirrhosisHistologic studyC. FiftyCirrhosisSide effectsPatientsCollagen synthesisLiverBiopsyPreliminary evidence
1987
Hemodynamic evaluation of isosorbide dinitrate in alcoholic cirrhosis Pharmacokinetic-hemodynamic interactions
Blei A, Garcia-Tsao G, Groszmann R, Kahrilas P, Ganger D, Morse S, Fung H. Hemodynamic evaluation of isosorbide dinitrate in alcoholic cirrhosis Pharmacokinetic-hemodynamic interactions. Gastroenterology 1987, 93: 576-583. PMID: 3301517, DOI: 10.1016/0016-5085(87)90921-8.Peer-Reviewed Original ResearchConceptsIsosorbide dinitratePortal pressureArterial pressureHemodynamic changesHemodynamic evaluationHepatic vein wedge pressureHepatic venous gradientSystemic hemodynamic changesMean arterial pressureEffects of placeboValues 4 hStable cirrhoticsAlcoholic cirrhosisCardiac indexPortal hypertensionWedge pressureHemodynamic benefitsVenous gradientVasoactive metabolitesPharmacologic agentsIndividual patientsBaseline valuesExperimental animalsDinitratePatientsPortal hemodynamics during nitroglycerin administration in cirrhotic patients
Garcia‐Tsao G, Groszmann R. Portal hemodynamics during nitroglycerin administration in cirrhotic patients. Hepatology 1987, 7: 805-809. PMID: 3115881, DOI: 10.1002/hep.1840070502.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientVenous pressure gradientEffects of nitroglycerinMean arterial pressurePortal pressureArterial pressureNitroglycerin administrationBlood flowExperimental animalsAzygos blood flowPortal venous hemodynamicsPortal hypertensive patientsPortal blood flowVenous dilatorHypertensive patientsAlcoholic cirrhosisArterial vasodilatorCirrhotic patientsBlood pressurePortal hemodynamicsSublingual nitroglycerinVenous hemodynamicsHemodynamic responsePeak changesHeart rate