2024
Serum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis
Yamazaki T, Kouno T, Hsu C, Hartmann P, Mayo S, Zhang X, Stärkel P, Bosques-Padilla F, Verna E, Abraldes J, Brown R, Vargas V, Altamirano J, Caballería J, Shawcross D, Louvet A, Lucey M, Mathurin P, Garcia-Tsao G, Bataller R, Investigators A, Schnabl B. Serum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis. Hepatology 2024, 80: 403-417. PMID: 38377466, PMCID: PMC11268475, DOI: 10.1097/hep.0000000000000777.Peer-Reviewed Original ResearchAlcohol-associated hepatitisAlcohol use disorderSevere AHAH patientsAhR activationMicrobiota-derived tryptophan metabolitesSurvival rateAssociated with high mortalityCumulative survival rateAssociated with survivalAryl hydrocarbon receptor activationMulticenter cohortFecal metabolomePrognostic markerTryptophan metabolitesReceptor activationAryl hydrocarbon receptorPatientsUse disorderAH cohortSerumHigher mortalityAhRHepatitisCohort
1998
The diagnostic and predictive value of ascites nitric oxide levels in patients with spontaneous bacterial peritonitis
Garcia‐Tsao G, Angulo P, Garcia J, Groszmann R, Cadelina G. The diagnostic and predictive value of ascites nitric oxide levels in patients with spontaneous bacterial peritonitis. Hepatology 1998, 28: 17-21. PMID: 9657091, DOI: 10.1002/hep.510280104.Peer-Reviewed Original ResearchConceptsSpontaneous bacterial peritonitisCirrhotic patientsNO levelsSterile ascitesBacterial peritonitisDiagnosis of SBPNitric oxideBaseline NO levelsSerum NO levelsCulture-negative peritonitisSevere liver diseaseNitric oxide metabolitesUseful prognostic markerNitric oxide levelsSignificant direct correlationInitial paracentesisLiver diseaseSerum levelsOxide metabolitesPrognostic markerOxide levelsPeritonitisAscitesAscites samplesPatients