2023
Machine learning liver histology scores correlate with portal hypertension assessments in nonalcoholic steatohepatitis cirrhosis
Noureddin M, Goodman Z, Tai D, Chng E, Ren Y, Boudes P, Shlevin H, Garcia‐Tsao G, Harrison S, Chalasani N. Machine learning liver histology scores correlate with portal hypertension assessments in nonalcoholic steatohepatitis cirrhosis. Alimentary Pharmacology & Therapeutics 2023, 57: 409-417. PMID: 36647687, PMCID: PMC10107331, DOI: 10.1111/apt.17363.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientPresence of varicesEnd of treatmentValidation cohortLiver histology scoresPhase 2b trialPrimary efficacy endpointVenous pressure gradientDevelopment of varicesNonalcoholic steatohepatitis cirrhosisImportant histologic featuresImportant clinical relevanceHVPG changesEfficacy endpointHVPG measurementLiver histologyUpper endoscopyLiver biopsyLiver outcomesHistologic variablesNASH cirrhosisHistologic featuresHypertension assessmentCirrhosis (HALT-C) TrialClinical trials
2012
Quantitative histological‐hemodynamic correlations in cirrhosis
Sethasine S, Jain D, Groszmann RJ, Garcia‐Tsao G. Quantitative histological‐hemodynamic correlations in cirrhosis. Hepatology 2012, 55: 1146-1153. PMID: 22109744, PMCID: PMC3721182, DOI: 10.1002/hep.24805.Peer-Reviewed Original ResearchConceptsSignificant portal hypertensionPortal hypertensionFibrosis areaLiver biopsyCirrhotic nodulesNodule sizeHVPG measurementPortal pressureIndependent predictorsSeptal thicknessFibrous septaBiopsyPathophysiological implicationsCirrhosisHVPGPatientsSemiquantitative analysisNodulesOnly parameterHypertensionNumber of nodules
2008
Prediction of clinical outcomes in primary biliary cirrhosis by serum enhanced liver fibrosis assay
Mayo MJ, Parkes J, Adams‐Huet B, Combes B, Mills AS, Markin RS, Rubin R, Wheeler D, Contos M, West AB, Saldana S, Getachew Y, Butsch R, Luketic V, Peters M, Di Bisceglie A, Bass N, Lake J, Boyer T, Martinez E, Boyer J, Garcia‐Tsao G, Barnes D, Rosenberg WM. Prediction of clinical outcomes in primary biliary cirrhosis by serum enhanced liver fibrosis assay. Hepatology 2008, 48: 1549-1557. PMID: 18846542, PMCID: PMC2597274, DOI: 10.1002/hep.22517.Peer-Reviewed Original ResearchConceptsPrimary biliary cirrhosisSerum fibrosis markersBiliary cirrhosisLiver biopsyClinical progressionFibrosis markersLiver fibrosisPrognostic informationPrognostic performanceSerial liver biopsy specimensEnd-stage liver diseaseLong-term prognostic informationLiver-related deathPositive antimitochondrial antibodyMayo risk scoreEvent-free survivalAppropriate clinical settingSerum hyaluronic acidEnhanced liver fibrosisLiver biopsy specimensAccurate noninvasive measureFibrosis algorithmsPBC subjectsVariceal bleedBiopsy complications
2006
Liver involvement in hereditary hemorrhagic telangiectasia: consensus recommendations
Buscarini E, Plauchu H, Tsao G, White RI, Sabbà C, Miller F, Saurin JC, Pelage JP, Lesca G, Marion MJ, Perna A, Faughnan ME. Liver involvement in hereditary hemorrhagic telangiectasia: consensus recommendations. Liver International 2006, 26: 1040-1046. PMID: 17032403, DOI: 10.1111/j.1478-3231.2006.01340.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHereditary hemorrhagic telangiectasiaLiver involvementHemorrhagic telangiectasiaIntensive medical therapyFormal consensus development processMinority of patientsFirst-line imagingFocal nodular hyperplasiaConsensus development processHHT populationLiver biopsyMedical therapyClinical managementNodular hyperplasiaConsensus statementConsensus recommendationsInvasive therapyDoppler USGeneral populationNominal group techniquePatientsTherapeutic issuesMedian scoreTherapyInvolvement
1990
Usefulness of the histologic and microbiologic study of liver biopsy in the diagnosis of fever of unknown origin.
Páez-Rodríguez O, García-Tsao G, Sifuentes J. Usefulness of the histologic and microbiologic study of liver biopsy in the diagnosis of fever of unknown origin. Revista De Gastroenterología De México 1990, 55: 1-6. PMID: 2291060.Peer-Reviewed Original Research
1988
Deficiency of protein C in patients with portal vein thrombosis
Orozco H, Guraieb E, Takahashi T, Garcia‐Tsao G, Hurtado R, Anaya R, Ruiz‐Arguelles G, Hernandez‐Ortiz J, Casillas M, Guevara L. Deficiency of protein C in patients with portal vein thrombosis. Hepatology 1988, 8: 1110-1111. PMID: 3262079, DOI: 10.1002/hep.1840080522.Peer-Reviewed Original ResearchConceptsPortal vein thrombosisVein thrombosisThromboembolic diseaseProtein C deficiencyPortal hypertensionC deficiencyProtein CMesenteric venous thrombosisSystemic thromboembolic diseaseUpper gastrointestinal bleedingTime of surgeryGastroesophageal varicesGastrointestinal bleedingIntestinal resectionVenous thrombosisLiver biopsySugiura procedureRecurrent episodesThrombosisPatientsDiseaseHypertensionVaricesSurgeryDeficiencyColchicine in the Treatment of Cirrhosis of the Liver
Kershenobich D, Vargas F, Garcia-Tsao G, Tamayo R, Gent M, Rojkind M. Colchicine in the Treatment of Cirrhosis of the Liver. New England Journal Of Medicine 1988, 318: 1709-1713. PMID: 3287167, DOI: 10.1056/nejm198806303182602.Peer-Reviewed Original ResearchConceptsTreatment of cirrhosisPlacebo groupHistologic improvementColchicine groupSurvival rateMinimal portal fibrosisPlacebo-controlled trialPercent of patientsUse of colchicineAlcoholic cirrhosisOverall survivalPortal fibrosisMore biopsiesHepatic cirrhosisLiver biopsyPosthepatitic cirrhosisHistologic studyC. FiftyCirrhosisSide effectsPatientsCollagen synthesisLiverBiopsyPreliminary evidence
1986
Quantitative US attenuation in normal liver and in patients with diffuse liver disease: importance of fat.
Taylor K, Riely C, Hammers L, Flax S, Weltin G, Garcia-Tsao G, Conn H, Kuc R, Barwick K. Quantitative US attenuation in normal liver and in patients with diffuse liver disease: importance of fat. Radiology 1986, 160: 65-71. PMID: 3520657, DOI: 10.1148/radiology.160.1.3520657.Peer-Reviewed Original Research