2013
New Consensus Definition of Acute Kidney Injury Accurately Predicts 30-Day Mortality in Patients With Cirrhosis and Infection
Wong F, O'Leary JG, Reddy KR, Patton H, Kamath PS, Fallon MB, Garcia–Tsao G, Subramanian RM, Malik R, Maliakkal B, Thacker LR, Bajaj JS, Disease N. New Consensus Definition of Acute Kidney Injury Accurately Predicts 30-Day Mortality in Patients With Cirrhosis and Infection. Gastroenterology 2013, 145: 1280-1288.e1. PMID: 23999172, PMCID: PMC4418483, DOI: 10.1053/j.gastro.2013.08.051.Peer-Reviewed Original ResearchConceptsAcute kidney injuryDays of hospitalizationKidney injuryOrgan failureConsensus definitionHigher Child-Pugh scoreIrreversible acute kidney injuryChild-Pugh scoreHigh MELD scoreSerum creatinine levelsMean arterial pressureIntensive care unitLength of stayNew consensus definitionStable baseline valuesAKI episodesRenal recoveryHospital stayMELD scoreCreatinine levelsArterial pressureCare unitProspective studyBaseline valuesConsensus conferenceAcute Kidney Injury in Patients With Cirrhosis: Perils and Promise
Belcher JM, Parikh CR, Garcia–Tsao G. Acute Kidney Injury in Patients With Cirrhosis: Perils and Promise. Clinical Gastroenterology And Hepatology 2013, 11: 1550-1558. PMID: 23583467, PMCID: PMC3840046, DOI: 10.1016/j.cgh.2013.03.018.Commentaries, Editorials and LettersConceptsCreatinine levelsSodium levelsRenal Disease Study equationPacked red blood cellsTotal serum bilirubin levelsAcute kidney injurySerum creatinine levelsMental status changesRenal tubular epithelial cellsSerum sodium levelsChronic liver diseaseGlomerular filtration rateInternational normalization ratioModification of DietIntensive care unitUrine sodium levelSerum bilirubin levelsFresh frozen plasmaChronic alcohol abuseTubular epithelial cellsHepatitis CKidney injuryRed blood cellsBlood pressureFractional excretion
2011
Intensive care of the patient with cirrhosis
Olson JC, Wendon JA, Kramer DJ, Arroyo V, Jalan R, Garcia‐Tsao G, Kamath PS. Intensive care of the patient with cirrhosis. Hepatology 2011, 54: 1864-1872. PMID: 21898477, DOI: 10.1002/hep.24622.Peer-Reviewed Original ResearchConceptsMultiple organ failureIntensive care unitCare unitOrgan failureLiver functionSignificant survival benefitPresence of infectionFurther deteriorationQuality of lifeNumber of organsLiver support systemsAlcoholic hepatitisLiver transplantationVariceal hemorrhageAcute deteriorationCommon organLiver dysfunctionSurvival benefitViral hepatitisIll patientsIntensive careCritical carePatientsHigh mortalityTeam approach