2023
The effect of endoscopic gastric plication on portosystemic pressure gradient in patients with nonalcoholic fatty liver disease and compensated advanced chronic liver disease
Jirapinyo P, Thompson C, Garcia-Tsao G, Zucker S, Ryou M. The effect of endoscopic gastric plication on portosystemic pressure gradient in patients with nonalcoholic fatty liver disease and compensated advanced chronic liver disease. Endoscopy 2023, 56: 56-62. PMID: 37532114, DOI: 10.1055/a-2146-8857.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseEndoscopic gastric plicationAdvanced chronic liver diseaseFatty liver diseasePortosystemic pressure gradientChronic liver diseaseLiver diseaseTotal weight lossGastric plicationNoninvasive testsBaseline median body-mass indexMedian body mass indexPercent total weight lossWeight lossProportion of patientsProspective pilot studyBody mass indexLiver stiffness measurementWeight loss proceduresGoal of therapyHepatic decompensationSecondary outcomesPrimary outcomeMass indexPatients
2021
SACRED: Effect of simvastatin on hepatic decompensation and death in subjects with high-risk compensated cirrhosis: Statins and Cirrhosis: Reducing Events of Decompensation
Kaplan D, Mehta R, Garcia-Tsao G, Albrecht J, Aytaman A, Baffy G, Bajaj J, Hernaez R, Hunt K, Ioannou G, Johnson K, Kanwal F, Lee T, Monto A, Pandya P, Schaubel D, Taddei T. SACRED: Effect of simvastatin on hepatic decompensation and death in subjects with high-risk compensated cirrhosis: Statins and Cirrhosis: Reducing Events of Decompensation. Contemporary Clinical Trials 2021, 104: 106367. PMID: 33771685, PMCID: PMC8422958, DOI: 10.1016/j.cct.2021.106367.Peer-Reviewed Original ResearchConceptsHepatic decompensationPortal hypertensionEvents of decompensationHepatic decompensation eventsLiver-related deathSignificant portal hypertensionAcceptable safety profileProspective human studiesRole of statinsChronic liver diseaseClasses of medicationsPatient-reported outcomesDevelopment of decompensationEffect of simvastatinVA Medical CenterCompensated cirrhosisDecompensation eventsStatin therapyVariceal hemorrhageCirrhotic patientsStandard therapyVascular reactivityExert pleiotropic effectsLiver diseaseRetrospective study
2009
Use of Over-the-Counter Analgesics Is Not Associated With Acute Decompensation in Patients With Cirrhosis
Khalid SK, Lane J, Navarro V, Garcia–Tsao G. Use of Over-the-Counter Analgesics Is Not Associated With Acute Decompensation in Patients With Cirrhosis. Clinical Gastroenterology And Hepatology 2009, 7: 994-999. PMID: 19394441, PMCID: PMC3777825, DOI: 10.1016/j.cgh.2009.04.015.Peer-Reviewed Original ResearchMeSH KeywordsAcetaminophenAdultAgedAged, 80 and overAlcohol DrinkingAnalgesics, Non-NarcoticAnti-Inflammatory Agents, Non-SteroidalCase-Control StudiesContraindicationsFemaleHospitalizationHumansLiverLiver CirrhosisMaleMiddle AgedNonprescription DrugsPainProspective StudiesSurveys and QuestionnairesYoung AdultConceptsNonsteroidal anti-inflammatory drugsAcute hepatic decompensationAnti-inflammatory drugsCirrhotic patientsAlcohol ingestionCounter analgesicsHepatic decompensationAlcoholic cirrhosisNonsteroidal anti-inflammatory drug useAnti-inflammatory drug useDecompensation of cirrhosisConsecutive cirrhotic patientsTertiary care hospitalEffect of analgesicsCase-control studyRecent alcohol ingestionRecent alcohol useAcetaminophen useLiver clinicNoncirrhotic controlsNoncirrhotic patientsAcute decompensationFurther decompensationCare hospitalConsecutive patients
2003
The management of ascites in cirrhosis: Report on the consensus conference of the international Ascites club
Moore K, Wong F, Gines P, Bernardi M, Ochs A, Salerno F, Angeli P, Porayko M, Moreau R, Garcia‐Tsao G, Jimenez W, Planas R, Arroyo V. The management of ascites in cirrhosis: Report on the consensus conference of the international Ascites club. Hepatology 2003, 38: 258-266. PMID: 12830009, DOI: 10.1053/jhep.2003.50315.Peer-Reviewed Original ResearchConceptsTransjugular intrahepatic portosystemic stent shuntInternational Ascites ClubDiuretic therapyRefractory ascitesColloid volume expansionModest salt restrictionLarge-volume paracentesisManagement of ascitesDevelopment of ascitesHepatic decompensationModerate ascitesGross ascitesLiver transplantationRenal dysfunctionSalt restrictionSodium excretionSodium restrictionTherapeutic paracentesisRenal functionSurvival benefitCommon complicationLiver diseasePancreatic ascitesAscitic patientsTIPS placement