2021
Sleep Disturbance Is Associated With the Presence of Portosystemic Collaterals in Patients With Compensated Cirrhosis
Balakrishnan M, Falker C, Conley S, Ciarleglio M, Deng Y, Redeker NS, Garcia‐Tsao G. Sleep Disturbance Is Associated With the Presence of Portosystemic Collaterals in Patients With Compensated Cirrhosis. Hepatology Communications 2021, 5: 491-501. PMID: 33681681, PMCID: PMC7917284, DOI: 10.1002/hep4.1636.Peer-Reviewed Original ResearchConceptsPortosystemic collateralsSleep disturbancesCompensated cirrhosisSleep fragmentationSleep characteristicsHigher international normalized ratioPittsburgh Sleep Quality IndexLower total sleep timeMultivariable linear regression analysisSignificant portal hypertensionGroup of patientsInternational normalized ratioEpworth Sleepiness ScaleSleep Quality IndexGreater sleep fragmentationCross-sectional studyMore sleep disturbancesMore sleep fragmentationTotal sleep timeLower sleep efficiencyPresence of collateralsCollateral presencePortal hypertensionLow albuminExcessive daytime
2001
Propranolol for the prevention of first esophageal variceal hemorrhage: A lifetime commitment?
Abraczinskas D, Ookubo R, Grace N, Groszmann R, Bosch J, Garcia‐Tsao G, Richardson C, Matloff D, Rodés J, Conn H. Propranolol for the prevention of first esophageal variceal hemorrhage: A lifetime commitment? Hepatology 2001, 34: 1096-1102. PMID: 11731997, DOI: 10.1053/jhep.2001.29305.Peer-Reviewed Original ResearchConceptsVariceal hemorrhageBeta blockersVariceal bleedingPrimary preventionFirst esophageal variceal hemorrhageWithdrawal of propranololOutcomes of patientsPlacebo-controlled trialEsophageal variceal hemorrhageGroup of patientsOriginal study populationUntreated populationBlocker therapyIndefinite administrationPlacebo groupPortal hypertensionProphylactic therapyProspective studyCumulative survivalProtective effectStudy populationHemorrhagePatientsPropranololBlockers
1991
Treatment of ascites with A single total paracentesis
Garcia-Tsao G. Treatment of ascites with A single total paracentesis. Hepatology 1991, 13: 1005-1007. PMID: 2029984, DOI: 10.1002/hep.1840130534.Peer-Reviewed Original ResearchConceptsPlasma renin activityEffective intravascular volumeTotal paracentesisCauses of readmissionLarge-volume paracentesisTense ascitesCirrhotic patientsProbability of readmissionRenin activityDextran 70Intravenous albuminRenal impairmentAldosterone concentrationClinical courseIntravascular volumeAscitic fluidTherapeutic proceduresEffects of paracentesisFirst hospital stayStandard liver testsRenal function testsGroup of patientsTreatment of ascitesFree water clearanceCause of death
1988
Distal splenorenal vs. portal‐systemic shunts after hemorrhage from varices: A randomized controlled trial
Grace N, Conn H, Resnick R, Groszmann R, Atterbury C, Wright S, Gusberg R, Vollman R, Garcia‐Tsao G, Fisher R, O'Hara E, McDermott W, Maselli J, Widrich W, Matloff D, Horst D, Banks N, Alberts J. Distal splenorenal vs. portal‐systemic shunts after hemorrhage from varices: A randomized controlled trial. Hepatology 1988, 8: 1475-1481. PMID: 3056820, DOI: 10.1002/hep.1840080602.Peer-Reviewed Original ResearchConceptsDistal splenorenal shunt groupPortal-systemic shuntsDistal splenorenal shuntShunt groupSplenorenal shuntVariceal hemorrhageMajor variceal hemorrhageReasonable operative riskRecurrent variceal hemorrhageGroup of patientsPortal venous flowShunt patientsAngiographic evidenceLate mortalityOperative mortalityCirrhotic patientsLiver groupOperative riskRenal veinInferior venaAngiographic demonstrationVenous flowPatientsTotal mortalityShunt