2023
Further decompensation in cirrhosis: Results of a large multicenter cohort study supporting Baveno VII statements
D’Amico G, Zipprich A, Villanueva C, Sordà J, Morillas R, Garcovich M, Retortillo M, Martinez J, Calès P, D’Amico M, Dollinger M, García-Guix M, Ballerga E, Tsochatzis E, Cirera I, Albillos A, Roquin G, Pasta L, Colomo A, Daruich J, Canete N, Boursier J, Dallio M, Gasbarrini A, Iacobellis A, Gobbo G, Merli M, Federico A, Baroni G, Pozzoni P, Addario L, Chessa L, Ridola L, Garcia-Tsao G. Further decompensation in cirrhosis: Results of a large multicenter cohort study supporting Baveno VII statements. Hepatology 2023, 79: 869-881. PMID: 37916970, DOI: 10.1097/hep.0000000000000652.Peer-Reviewed Original ResearchMulticenter cohort studyFurther decompensationLiver transplantFirst decompensationCumulative incidenceCohort studyLarge multicenter cohort studyCause-specific Cox modelsFive-year probabilityHazard ratioPrognostic weightPrognostic indicatorDecompensationCirrhosisCox modelPatientsAdvanced stageTransplantIncidenceMortalityDeathAscitesComplicationsMonthsLBP-09 Further decompensation as a new prognostic stage in cirrhosis. Results of a large multicenter cohort study supporting Baveno VII statements
D’Amico G, Garcia-Tsao G, Zipprich A, Villanueva C, Sorda J, Morillas R, Garcovich M, García-Retortillo M, Martinez J, Cales P, D’Amico M, Dollinger M, Garcia-Guix M, Ballerga E, Tsochatzis E, Cirera I, Albillos A, Roquin G, Pasta L, Colomo A, Hidalgo N, Boursier J, Dallio M, Gasbarrini A, Angelo I, Gobbo G, Merli M, Federico A, Svegliati-Baroni G, Pozzoni P, Addario L, Chessa L, Ridola L, Burroughs A. LBP-09 Further decompensation as a new prognostic stage in cirrhosis. Results of a large multicenter cohort study supporting Baveno VII statements. Journal Of Hepatology 2023, 78: s105-s106. DOI: 10.1016/s0168-8278(23)00591-3.Peer-Reviewed Original Research
2022
Concept of Further Decompensation and Recompensation
D’Amico G, Garcia-Tsao G. Concept of Further Decompensation and Recompensation. 2022, 523-535. DOI: 10.1007/978-3-031-08552-9_47.Peer-Reviewed Original ResearchPreventing Further Decompensation: Consensus Statements of Panel 7
Garcia-Tsao G, Reiberger T, Bureau C, D’Amico G, La Mura V, Piano S, Tandon P, Turco L. Preventing Further Decompensation: Consensus Statements of Panel 7. 2022, 579-583. DOI: 10.1007/978-3-031-08552-9_51.Peer-Reviewed Original Research
2021
Baveno VII – Renewing consensus in portal hypertension
de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C, Faculty B, Abraldes J, Albillos A, Baiges A, Bajaj J, Bañares R, Barrufet M, Benajiba L, Berzigotti A, Bureau C, Calvaruso V, Cardenas A, D’Amico G, De Gottardi A, Dell’Era A, Escorsell A, Fallowfield J, Ferral H, Francque S, Gaba R, Garcia-Pagàn J, Genescà J, Rodrigues S, Gracia-Sancho J, Han G, Hernandez-Gea V, Jia J, Kiladjian J, Krag A, Laleman W, La Mura V, Lens S, Luo X, Mandorfer M, Murad S, Paradis V, Patch D, Piano S, Pinzani M, Plessier A, Primignani M, Procopet B, Rautou P, Rudler M, Sarin S, Schepis F, Senzolo M, Shah V, Shukla A, Tandon P, Tellez L, Thabut D, Thiele M, Trebicka J, Tripathi D, Tsochatzis E, Turco L, Turon F, Valla D, Villanueva C, Wanless I, Yoshiji H. Baveno VII – Renewing consensus in portal hypertension. Journal Of Hepatology 2021, 76: 959-974. PMID: 35120736, PMCID: PMC11090185, DOI: 10.1016/j.jhep.2021.12.022.Peer-Reviewed Original ResearchConceptsPortal hypertensionAdvanced chronic liver diseaseHepatic venous pressure gradientAcute bleeding episodeSignificant portal hypertensionVenous pressure gradientChronic liver diseaseSplanchnic vein thrombosisCourse of cirrhosisRisk of deathNon-invasive toolBleeding episodesCompensated cirrhosisFurther decompensationVein thrombosisLiver diseaseBaveno VIVascular disordersFirst episodeHypertensionPersonalized careMedical literatureTherapeutic needsGold standardCirrhosisObeticholic Acid Decreases Intestinal Content of Enterococcus in Rats With Cirrhosis and Ascites
Yan K, Hung A, Parmer C, Yang H, Jain D, Lim B, Goodman AL, Garcia‐Tsao G. Obeticholic Acid Decreases Intestinal Content of Enterococcus in Rats With Cirrhosis and Ascites. Hepatology Communications 2021, 5: 1507-1517. PMID: 34510838, PMCID: PMC8435275, DOI: 10.1002/hep4.1740.Peer-Reviewed Original ResearchHigher serum albuminBacterial translocationObeticholic acidEnd of studyAspartate aminotransferaseLymph nodesIntestinal microbiomeIntestinal contentsSemisynthetic bile acidMesenteric lymph nodesEnd of treatmentCarbon tetrachloride inhalationExtra-intestinal sitesLower aspartate aminotransferaseFurther decompensationLiver injuryLiver functionPolymerase chain reactionExperimental cirrhosisPathogenic bacteriaCirrhosisHepatocyte deathDay 1Bile acidsPlacebo
2016
Secondary Prophylaxis in Special Patient Populations
Reiberger T, Moreau R, Ripoll C, Albillos A, Augustin S, Salerno F, Abraldes J, Garcia-Tsao G. Secondary Prophylaxis in Special Patient Populations. 2016, 317-332. DOI: 10.1007/978-3-319-23018-4_32.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSecondary prophylaxisRefractory ascitesVariceal bleedingSurvival benefitClinical nonrespondersClear precipitating eventProphylaxis of varicealBeta-blocker therapyBeta-blocker treatmentEndoscopic band ligationSpecial patient populationsAdvanced cirrhosisNSBB therapyVariceal rebleedingArterial hypotensionCirrhotic patientsFurther decompensationSerum creatinineBand ligationPatient populationProphylaxisHigh riskCurrent evidencePatientsAscites
2014
Prognostic Factors in Compensated and Decompensated Cirrhosis
Ripoll C, Zipprich A, Garcia-Tsao G. Prognostic Factors in Compensated and Decompensated Cirrhosis. Current Hepatology Reports 2014, 13: 171-179. DOI: 10.1007/s11901-014-0234-6.Peer-Reviewed Original ResearchHepatic venous pressure gradientPortal hypertensionPredictive factorsSignificant portal hypertensionSpecific predictive factorsVenous pressure gradientSerum albumin levelAlternative non-invasive methodDecompensated diseaseMELD scoreClinical decompensationFurther decompensationAlbumin levelsPrognostic factorsNon-invasive methodCirrhosisInvasive proceduresDecompensationDeathHypertensionNumber of studiesImportant predictorChildren's scoresRecent studiesScores
2009
Use of Over-the-Counter Analgesics Is Not Associated With Acute Decompensation in Patients With Cirrhosis
Khalid SK, Lane J, Navarro V, Garcia–Tsao G. Use of Over-the-Counter Analgesics Is Not Associated With Acute Decompensation in Patients With Cirrhosis. Clinical Gastroenterology And Hepatology 2009, 7: 994-999. PMID: 19394441, PMCID: PMC3777825, DOI: 10.1016/j.cgh.2009.04.015.Peer-Reviewed Original ResearchMeSH KeywordsAcetaminophenAdultAgedAged, 80 and overAlcohol DrinkingAnalgesics, Non-NarcoticAnti-Inflammatory Agents, Non-SteroidalCase-Control StudiesContraindicationsFemaleHospitalizationHumansLiverLiver CirrhosisMaleMiddle AgedNonprescription DrugsPainProspective StudiesSurveys and QuestionnairesYoung AdultConceptsNonsteroidal anti-inflammatory drugsAcute hepatic decompensationAnti-inflammatory drugsCirrhotic patientsAlcohol ingestionCounter analgesicsHepatic decompensationAlcoholic cirrhosisNonsteroidal anti-inflammatory drug useAnti-inflammatory drug useDecompensation of cirrhosisConsecutive cirrhotic patientsTertiary care hospitalEffect of analgesicsCase-control studyRecent alcohol ingestionRecent alcohol useAcetaminophen useLiver clinicNoncirrhotic controlsNoncirrhotic patientsAcute decompensationFurther decompensationCare hospitalConsecutive patients