2024
Setdb1-loss induces type-I interferons and immune clearance of melanoma.
McGeary M, Damsky W, Daniels A, Lang S, Xu Q, Song E, Huet-Calderwood C, Lou H, Paradkar S, Micevic G, Kaech S, Calderwood D, Turk B, Yan Q, Iwasaki A, Bosenberg M. Setdb1-loss induces type-I interferons and immune clearance of melanoma. Cancer Immunology Research 2024 PMID: 39589394, DOI: 10.1158/2326-6066.cir-23-0514.Peer-Reviewed Original ResearchT cell infiltrationMHC-I expressionType I interferonImmune clearanceCD8+ T cell-dependent mannerIncreased CD8+ T cell infiltrationCD8+ T cell infiltrationDecreased MHC-I expressionAnti-cancer immune responseT cell-dependent mannerCD8+ T cellsDecreased T-cell infiltrationComplete tumor clearanceImmunity to melanomaIncreased melanoma growthInflamed tumor microenvironmentLoss of SETDB1Type I interferon receptorTreatment of melanomaType I interferon signalingWhole-genome CRISPR screenEndogenous retrovirusesType I interferon expressionMetastatic diseaseTumor clearanceClinical and Histologic Variants of CD8+ Cutaneous T-Cell Lymphomas
Swallow M, Micevic G, Zhou A, Carlson K, Foss F, Girardi M. Clinical and Histologic Variants of CD8+ Cutaneous T-Cell Lymphomas. Cancers 2024, 16: 3087. PMID: 39272944, PMCID: PMC11394026, DOI: 10.3390/cancers16173087.Peer-Reviewed Original ResearchT-cell lymphomaPrimary cutaneous gamma/delta T-cell lymphomaSubcutaneous panniculitis-like T-cell lymphomaLymphoproliferative disordersMycosis fungoidesCD8+ cutaneous T-cell lymphomasCutaneous gamma/delta T-cell lymphomaPanniculitis-like T-cell lymphomaGamma/delta T-cell lymphomaCytotoxic T-cell lymphomaT-cell lymphoproliferative disorderAbnormal T-cell populationCutaneous T-cell lymphomaCytotoxic molecule expressionT cell populationsIndicator of prognosisAppropriate treatment planCD8-positiveAggressive entityLymphomatoid papulosisHistological variantsHistopathological differentiationTreatment algorithmCD8Clinical manifestations057 Single cell RNA and TCR sequencing reveals hyperexpansion of T cell clones and novel regulatory mechanisms of CD8+ T cells in murine alopcecia areata skin and draining lymph nodes
Wang Y, Yu W, Micevic G, Daccache J, Wang A, Park K, Wang G, Palmatier M, Wheeler J, King B, Damsky W. 057 Single cell RNA and TCR sequencing reveals hyperexpansion of T cell clones and novel regulatory mechanisms of CD8+ T cells in murine alopcecia areata skin and draining lymph nodes. Journal Of Investigative Dermatology 2024, 144: s10. DOI: 10.1016/j.jid.2024.06.073.Peer-Reviewed Original ResearchTumour necrosis is a valuable histopathological prognostic parameter in melanomas of the vulva and vagina
Roy S, Baig J, DeCoste R, Finch S, Sennik S, Kakadekar A, Sade S, Micevic G, Chergui M, Rahimi K, Flaman A, Trinh V, Osmond A. Tumour necrosis is a valuable histopathological prognostic parameter in melanomas of the vulva and vagina. Pathology 2024, 56: 854-864. PMID: 38906758, DOI: 10.1016/j.pathol.2024.03.008.Peer-Reviewed Original ResearchTumor necrosisVaginal melanomaPrognostic factorsDisease-specific mortalitySurvival outcomesKaplan-Meier log-rankAssociated with disease-specific mortalityKaplan-Meier survival analysisPositive lymph nodesHistopathological prognostic parametersMedian follow-upMetastasis-free survivalNon-metastatic patientsMultivariate Cox regressionTime to metastasisFollow-up dataTertiary Canadian hospitalProgression-freeTumor ulcerationMelanoma patientsPrognostic parametersLymph nodesAggressive malignancyImmunohistochemical markersLog-rankMelanoma tumour-infiltrating T-lymphocyte therapy heralds the era of cell-based immunotherapies for solid tumours
Talty R, Richmond R, Micevic G. Melanoma tumour-infiltrating T-lymphocyte therapy heralds the era of cell-based immunotherapies for solid tumours. British Journal Of Dermatology 2024, 190: 779-781. PMID: 38516835, DOI: 10.1093/bjd/ljae126.Peer-Reviewed Original ResearchCutaneous diatoms from diatomaceous earth mimicking myiasis infection
Roy S, Micevic G, McNiff J, Christensen S, Cowper S. Cutaneous diatoms from diatomaceous earth mimicking myiasis infection. Pathology 2024, 56: 742-743. PMID: 38471986, DOI: 10.1016/j.pathol.2023.12.416.Peer-Reviewed Original Research
2023
1025 Tumor-specific CD8+ T cells epigenetically licensed by IL-7R are critical for anti-tumor immunity in melanoma
Micevic G, Daniels A, Flem-Karlsen K, Park K, Talty R, McGeary M, Mirza H, Blackburn H, Sefik E, Cheung J, Hornick N, Aizenbud L, Joshi N, Kluger H, Iwasaki A, Bosenberg M, Flavell R. 1025 Tumor-specific CD8+ T cells epigenetically licensed by IL-7R are critical for anti-tumor immunity in melanoma. 2023, a1133-a1133. DOI: 10.1136/jitc-2023-sitc2023.1025.Peer-Reviewed Original ResearchNew insights into programmed cell death protein 1 blockade-associated cutaneous immune-related adverse events
Micevic G, Daniels A, Flavell R. New insights into programmed cell death protein 1 blockade-associated cutaneous immune-related adverse events. British Journal Of Dermatology 2023, 189: 355-357. PMID: 37471669, PMCID: PMC10503525, DOI: 10.1093/bjd/ljad236.Peer-Reviewed Original ResearchConceptsCutaneous immune-related adverse eventsImmune-related adverse eventsSelf-reactive T cellsCheckpoint receptor PD-1PD-1 inhibitorsHalf of patientsImmune checkpoint blockadeAntitumor immune responseReceptor PD-1Adverse eventsCheckpoint blockadePD-1Immune toleranceCTLA-4T cellsImmune responseLandmark studiesMolecular mechanismsFunctional roleCritical functional rolePatientsBlockadeDermatologistsImportant cluesIL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memory
Micevic G, Daniels A, Flem-Karlsen K, Park K, Talty R, McGeary M, Mirza H, Blackburn H, Sefik E, Cheung J, Hornick N, Aizenbud L, Joshi N, Kluger H, Iwasaki A, Bosenberg M, Flavell R. IL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memory. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2304319120. PMID: 37459511, PMCID: PMC10372654, DOI: 10.1073/pnas.2304319120.Peer-Reviewed Original ResearchConceptsIL-7R expressionT cellsIL-7RAntitumor memorySuperior antitumor efficacyCell-based therapiesTumor-specific T cellsAntigen-specific T cellsAntitumor efficacyPowerful antitumor immune responseMarkers of exhaustionTumor-specific CD8Antitumor immune responseIndependent prognostic factorAntitumor immune memoryMemory T cellsMajor risk factorSuperior antitumor activityFunctional CD8Memory CD8Prognostic factorsSurgical resectionAdvanced melanomaLymph nodesNaive mice1234 Immunotherapy induces clonal expansion of cytotoxic tumor-specific TILs in a model of melanoma
Micevic G, Daniels A, Flem-Karlsen K, Talty R, Park K, Bosenberg M, Flavell R. 1234 Immunotherapy induces clonal expansion of cytotoxic tumor-specific TILs in a model of melanoma. Journal Of Investigative Dermatology 2023, 143: s212. DOI: 10.1016/j.jid.2023.03.1248.Peer-Reviewed Original ResearchISID1234 - Immunotherapy induces clonal expansion of cytotoxic tumor-specific TILs in a model of melanoma
Micevic G. ISID1234 - Immunotherapy induces clonal expansion of cytotoxic tumor-specific TILs in a model of melanoma. 2023 DOI: 10.26226/m.64199a0860d56100127c2ac1.Peer-Reviewed Original Research
2022
The Crossroads of Cancer Epigenetics and Immune Checkpoint Therapy.
Micevic G, Bosenberg M, Yan Q. The Crossroads of Cancer Epigenetics and Immune Checkpoint Therapy. Clinical Cancer Research 2022, 29: 1173-1182. PMID: 36449280, PMCID: PMC10073242, DOI: 10.1158/1078-0432.ccr-22-0784.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsImmune checkpoint inhibitorsImmune checkpoint therapyT cell exhaustionCheckpoint therapyAntitumor immune responseT cell populationsCell-intrinsic immunityTypes of cancerViral mimicry responseLow response rateCheckpoint inhibitorsCurrent immunotherapiesPancreatic cancerSustained responsePreclinical modelsTreatment outcomesImmune responseEndogenous antigensResponse rateTumor typesMultiple epigenetic regulatorsCritical mediatorLow immunogenicityTherapyCancerErythrodermic scabies in an immunocompetent patient
Talty R, Micevic G, Damsky W, King BA. Erythrodermic scabies in an immunocompetent patient. JAAD Case Reports 2022, 29: 112-115. PMID: 36262356, PMCID: PMC9573821, DOI: 10.1016/j.jdcr.2022.08.045.Peer-Reviewed Original ResearchLeukoderma Induced by Rotigotine Patch, a Transdermal Dopamine Agonist
Talty R, Micevic G, Wang A, Ko CJ, Damsky W. Leukoderma Induced by Rotigotine Patch, a Transdermal Dopamine Agonist. Case Reports In Dermatology 2022, 14: 214-218. PMID: 36158852, PMCID: PMC9459519, DOI: 10.1159/000525894.Peer-Reviewed Original ResearchRestless legs syndromeRotigotine patchTransdermal patchRotigotine transdermal patchTransdermal dopamine agonistsPotential side effectsAbsence of melanocytesDopamine agonismSystemic medicationsTopical medicationsDopamine agonistsLegs syndromeCase reportHistopathologic examinationDermal-epidermal junctionAnterior shoulderPharmacologic substancesSide effectsPatch applicationPotential mechanismsLeukodermaMedicationsPatientsSyndromeAgonists
2021
Targeting the neonatal Fc receptor in pemphigus: safety first
Micevic G, Lo SN, Rajan N. Targeting the neonatal Fc receptor in pemphigus: safety first. British Journal Of Dermatology 2021, 186: 389-390. PMID: 34961930, PMCID: PMC9295899, DOI: 10.1111/bjd.20939.Peer-Reviewed Original ResearchKDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements
Zhang SM, Cai WL, Liu X, Thakral D, Luo J, Chan LH, McGeary MK, Song E, Blenman KRM, Micevic G, Jessel S, Zhang Y, Yin M, Booth CJ, Jilaveanu LB, Damsky W, Sznol M, Kluger HM, Iwasaki A, Bosenberg MW, Yan Q. KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements. Nature 2021, 598: 682-687. PMID: 34671158, PMCID: PMC8555464, DOI: 10.1038/s41586-021-03994-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorDNA-Binding ProteinsEpigenesis, GeneticGene SilencingHeterochromatinHistone-Lysine N-MethyltransferaseHumansInterferon Type IJumonji Domain-Containing Histone DemethylasesMaleMelanomaMiceMice, Inbred C57BLMice, KnockoutNuclear ProteinsRepressor ProteinsRetroelementsTumor EscapeConceptsImmune checkpoint blockadeImmune evasionCheckpoint blockadeImmune responseAnti-tumor immune responseRobust adaptive immune responseTumor immune evasionAnti-tumor immunityAdaptive immune responsesType I interferon responseDNA-sensing pathwayMouse melanoma modelImmunotherapy resistanceMost patientsCurrent immunotherapiesTumor immunogenicityImmune memoryMelanoma modelCytosolic RNA sensingRole of KDM5BConsiderable efficacyInterferon responseImmunotherapyEpigenetic therapyBlockade
2020
Perniolike lesions and coagulopathy in a patient with COVID-19 infection
Micevic G, Morris J, Lee AI, King BA. Perniolike lesions and coagulopathy in a patient with COVID-19 infection. JAAD Case Reports 2020, 6: 1294-1296. PMID: 32953959, PMCID: PMC7491482, DOI: 10.1016/j.jdcr.2020.08.042.Peer-Reviewed Original Research668 Ulcerated melanomas exhibit epigenetic changes in epidermal and immune response genes
Micevic G, Bosenberg M. 668 Ulcerated melanomas exhibit epigenetic changes in epidermal and immune response genes. Journal Of Investigative Dermatology 2020, 140: s90. DOI: 10.1016/j.jid.2020.03.680.Peer-Reviewed Original ResearchStructure-Guided Identification of DNMT3B Inhibitors
Newton AS, Faver JC, Micevic G, Muthusamy V, Kudalkar SN, Bertoletti N, Anderson KS, Bosenberg MW, Jorgensen WL. Structure-Guided Identification of DNMT3B Inhibitors. ACS Medicinal Chemistry Letters 2020, 11: 971-976. PMID: 32435413, PMCID: PMC7236258, DOI: 10.1021/acsmedchemlett.0c00011.Peer-Reviewed Original ResearchUltrahigh-performance liquid chromatographyStructure-activity dataGood selectivityExploratory synthesisStructure-Guided IdentificationCrystal structureVirtual screeningAnalytical assaysActive compoundsLiquid chromatographyCompoundsSmall molecule inhibitorsPotent beingHomology modelAdditional inhibitorsAnaloguesFluorogenic assayMolecule inhibitorsSelectivitySynthesisChromatographyDockingStructureHereinICRAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci
Vohhodina J, Toomire KJ, Petit SA, Micevic G, Kumari G, Botchkarev VV, Li Z, Livingston DM, Hu Y. RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 2084-2091. PMID: 31932421, PMCID: PMC6995001, DOI: 10.1073/pnas.1908003117.Peer-Reviewed Original ResearchConceptsHomologous recombination-mediated repairNuclear fociRecombination-mediated repairDNA repair fociPoly ADP-ribosylationProtein RAP80Chromatin structureChromosome integrityBRCA1 complexGenome disordersRepair fociRAP80Intracellular developmentPresence of BRCA1C complexActivity promotesSimultaneous lossBRCA1Complex formationNormal interactionComplexesPARsylationDNARibosylationChromosomal disorders