2023
Altered Resting-State Activity and Connectivity in Late-Life Depression with Suicidal Ideation
Wang L, Manning K, Pearlson G, Steffens D. Altered Resting-State Activity and Connectivity in Late-Life Depression with Suicidal Ideation. American Journal Of Geriatric Psychiatry 2023, 31: e22-e23. DOI: 10.1016/j.jagp.2023.02.031.Peer-Reviewed Original ResearchDefault mode networkVentrolateral prefrontal cortexLate-life depressionFunctional connectivityPrefrontal cortexOlder adultsOlder depressed adultsBrain activityDepressed adultsSuicidal ideationGreater brain activityVisual cortexWeaker functional connectivityStronger functional connectivityResting-state fMRI dataResting-state activitySuicidal behaviorWhole-brain voxelwiseNon-SI groupROI functional connectivityDepression severitySI groupCerebellar cortexCerebellar functional connectivityResting activity
2020
O2.6. DELUSIONS ASSOCIATED WITH ABNORMAL FRONTOSTRIATAL EFFECTIVE CONNECTIVITY IN A SPECTRAL DCM ANALYSIS OF RESTING STATE FMRI
Okuneye V, Clementz B, Gershon E, Keshavan M, McDowell J, Pearlson G, Tamminga C, Sweeney J, Keedy S. O2.6. DELUSIONS ASSOCIATED WITH ABNORMAL FRONTOSTRIATAL EFFECTIVE CONNECTIVITY IN A SPECTRAL DCM ANALYSIS OF RESTING STATE FMRI. Schizophrenia Bulletin 2020, 46: s5-s5. PMCID: PMC7234244, DOI: 10.1093/schbul/sbaa028.011.Peer-Reviewed Original ResearchR-DLPFCEffective connectivityState effective connectivityDelusional severityPrefrontal cortexState fMRIRight dorsolateral prefrontal cortexVentrolateral prefrontal cortexDynamic causal modelingDorsolateral prefrontal cortexSignificant effective connectivityEffective connectivity resultsEffective connectivity differencesSpectral dynamic causal modelingResting-state fMRISubcortical brain regionsIntermediate Phenotypes (B-SNIP) studyNeurocognitive processesFMRI studyFrontostriatal connectivityPrediction errorVLPFCFalse beliefsDelusion severityDLPFC