2000
Sex Differences in Inferior Parietal Lobule Volume in Schizophrenia
Frederikse M, Lu A, Aylward E, Barta P, Sharma T, Pearlson G. Sex Differences in Inferior Parietal Lobule Volume in Schizophrenia. American Journal Of Psychiatry 2000, 157: 422-427. PMID: 10698819, DOI: 10.1176/appi.ajp.157.3.422.Peer-Reviewed Original ResearchConceptsGray matter volumeLobule volumesFemale subjectsSchizophrenic patientsMatter volumeMale subjectsFemale schizophrenic subjectsSex differencesClinical disease expressionMale schizophrenic patientsAssociation cortical regionsFemale schizophrenic patientsHealthy female subjectsHealthy male subjectsPathophysiology of schizophreniaVolumetric sex differencesInferior parietal lobuleCortical regionsSchizophrenic subjectsParietal lobuleDisease expressionPatientsSchizophreniaSubjectsMagnetic resonance
1999
Lack of normal pattern of cerebral asymmetry in familial schizophrenic patients and their relatives — The Maudsley Family Study
Sharma T, Lancaster E, Sigmundsson T, Lewis S, Takei N, Gurling H, Barta P, Pearlson G, Murray R. Lack of normal pattern of cerebral asymmetry in familial schizophrenic patients and their relatives — The Maudsley Family Study. Schizophrenia Research 1999, 40: 111-120. PMID: 10593451, DOI: 10.1016/s0920-9964(99)00143-7.Peer-Reviewed Original ResearchConceptsSchizophrenic patientsOccipitoparietal regionsControl subjectsNormal patternCortical regionsLack of asymmetryFamilial schizophrenic patientsNormal cerebral asymmetryHealthy control subjectsFirst-degree relativesObligate carriersCerebral asymmetryRegional brain volumesUnrelated control subjectsDegree relativesRight sensorimotorNormal brain asymmetryBrain volumeMaudsley Family StudyPatientsOccipital asymmetryUnaffected relativesSchizophreniaBrain asymmetryNormal asymmetry
1997
Superior temporal gyrus and planum temporale in schizophrenia: A selective review
Pearlson G. Superior temporal gyrus and planum temporale in schizophrenia: A selective review. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1997, 21: 1203-1229. PMID: 9460087, DOI: 10.1016/s0278-5846(97)00159-0.Peer-Reviewed Original ResearchConceptsSuperior temporal gyrusPlanum temporaleTemporal gyrusNon-human primate researchPET/fMRIFormal thought disorderFunctional pathologySchizophrenic patientsAuditory hallucinationsTemporolimbic areasNeocortical regionsStructural abnormalitiesBrain regionsNeocortical networksExperience hallucinationsFunctional studiesCortical networksNormal asymmetrySchizophreniaThought disorderPatientsNormal structureVolume reductionGyrusPrimate researchQuantification of Neuroreceptors in the Living Human Brain
Wong *, Pearlson ‡, Tune ‡, Young *, Meltzer *, Dannals *, Ravert *, Reith *, Kuhar †, Gjedde ¶. Quantification of Neuroreceptors in the Living Human Brain. Cerebrovascular And Brain Metabolism Reviews 1997, 17: 331-342. PMID: 9119906, DOI: 10.1097/00004647-199703000-00010.Peer-Reviewed Original ResearchConceptsD2-like dopamine receptorsDrug-naive schizophrenic patientsDopamine receptorsSchizophrenic patientsIllness patientsPatient groupControl subjectsReceptor densityD2 dopamine receptor densityDrug-naive schizophreniaDopamine receptor densityLiving Human BrainBipolar affective illnessD2 dopamine receptorsQuantification of NeuroreceptorsPositron emission tomographyEffect of ageBrain uptakeAffective illnessBipolar illnessNonpsychotic patientsCaudate nucleusNormal controlsNormal volunteersPatientsMedial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder
Pearlson G, Barta P, Powers R, Menon R, Richards S, Aylward E, Federman E, Chase G, Petty R, Tien A. Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biological Psychiatry 1997, 41: 1-14. PMID: 8988790, DOI: 10.1016/s0006-3223(96)00373-3.Peer-Reviewed Original ResearchConceptsSuperior temporal gyrusAnterior superior temporal gyrusBipolar disorderSchizophrenic patientsSuperior temporal gyral volumeMagnetic resonance imaging studyTemporal lobe changesMedial temporal structuresRight anterior superior temporal gyrusResonance imaging studyGlobal brain measuresPosterior superior temporal gyrusGyral volumeHealthy controlsMRI measuresTemporal lobeBipolar patientsBipolar subjectsNormal controlsImaging studiesTemporal gyrusPatientsSchizophreniaBilateral volumesBrain measures
1995
Cingulate gyrus in schizophrenic patients and normal volunteers
Noga J, Aylward E, Barta P, Pearlson G. Cingulate gyrus in schizophrenic patients and normal volunteers. Psychiatry Research 1995, 61: 201-208. PMID: 8748465, DOI: 10.1016/0925-4927(95)02612-2.Peer-Reviewed Original ResearchConceptsSeverity of hallucinationsCingulate gyrusNormal volunteersMagnetic resonance imaging sectionsPosterior cingulate gyrusPatient groupSchizophrenic patientsBrain volumeParental socioeconomic statusCingulate regionsPatientsCingulate structuresSocioeconomic statusInverse correlationGyrusInterrater reliabilityBonferroni correctionSchizophreniaSeverityVolunteersHallucinationsImaging sectionsLateral asymmetryGroupIn Vivo D2 Dopamine Receptor Density in Psychotic and Nonpsychotic Patients With Bipolar Disorder
Pearlson G, Wong D, Tune L, Ross C, Chase G, Links J, Dannals R, Wilson A, Ravert H, Wagner H, DePaulo J. In Vivo D2 Dopamine Receptor Density in Psychotic and Nonpsychotic Patients With Bipolar Disorder. JAMA Psychiatry 1995, 52: 471-477. PMID: 7771917, DOI: 10.1001/archpsyc.1995.03950180057008.Peer-Reviewed Original ResearchConceptsSchizophrenic patientsBipolar disorderBmax valuesNonpsychotic patientsNormal controlsPsychotic symptomsPsychotic patientsAffective disordersPositron emission tomographic scansD2 dopamine receptor densityNeuroleptic-naive schizophrenic patientsPositron emission tomographic studiesDopamine receptor densityReceptor density valuesDSM-III criteriaPresent State ExaminationPresence of psychosisEmission tomographic studiesHigher Bmax valuesPsychotic bipolar disorderNeuroleptic medicationReceptor BmaxMood abnormalitiesReceptor valuesTomographic scan
1993
Dopamine D2 receptor density estimates in schizophrenia: A positron emission tomography study with11C-N-methylspiperone
Tune L, Wong D, Pearlson G, Strauss M, Young T, Shaya E, Dannals R, Wilson A, Ravert H, Sapp J, Cooper T, Chase G, Wagner H. Dopamine D2 receptor density estimates in schizophrenia: A positron emission tomography study with11C-N-methylspiperone. Psychiatry Research 1993, 49: 219-237. PMID: 7909948, DOI: 10.1016/0165-1781(93)90063-m.Peer-Reviewed Original ResearchConceptsPositron emission tomographySchizophrenic patientsBmax valuesEntire groupControl subjectsEmission tomographyDopamine D2 receptor densityNeuroleptic-free patientsDuration of illnessChronic schizophrenic patientsD2 receptor densityClinical characteristicsPatient populationReceptor abnormalitiesCorpus striatumClinical dataReceptor densityPatientsControl groupFunction of ageLate manifestationDifferent radioligandsFour-compartment modelSignificant differencesRadioligandDopamine receptor density measured by C-11 raclopride and NMSP in the same schizophrenic patients and normal subjects
Wong D, Tune L, Shaya E, Pearlson G, Yung B, Dannals R, Wilson A, Ravert H, Wagner H, Gjedde A. Dopamine receptor density measured by C-11 raclopride and NMSP in the same schizophrenic patients and normal subjects. Schizophrenia Research 1993, 9: 212. DOI: 10.1016/0920-9964(93)90458-u.Peer-Reviewed Original Research
1992
Elevated dopamine 2 receptor density in 23 schizophrenic patients: A positron emission tomography study with [11C]N- methylspiperone
Tune L, Wong D, Pearlson G. Elevated dopamine 2 receptor density in 23 schizophrenic patients: A positron emission tomography study with [11C]N- methylspiperone. Schizophrenia Research 1992, 6: 147. DOI: 10.1016/0920-9964(92)90218-t.Peer-Reviewed Original ResearchPositron emission tomographyReceptor densitySchizophrenic patientsEmission tomographyPatientsMethylspiperone
1988
Late-Onset Schizophrenia Studying Clinical Validity
V.Jeste D, Harris M, Pearlson G, Rabins P, Lesser I, Miller B, Coles C, Yassa R. Late-Onset Schizophrenia Studying Clinical Validity. Psychiatric Clinics Of North America 1988, 11: 1-13. PMID: 3380754, DOI: 10.1016/s0193-953x(18)30513-6.Peer-Reviewed Original ResearchConceptsLate-onset schizophreniaSchizophrenic patientsYoung schizophrenic patientsClinical characteristicsChronic courseAge 45Onset schizophreniaParanoid typeClinical validityAuditory hallucinationsLow dosesBizarre delusionsSchizophreniaPatientsRelevant literatureNeurolepticsIllnessDosesHallucinations