2023
Peripheral inflammatory subgroup differences in anterior Default Mode network and multiplex functional network topology are associated with cognition in psychosis
Lizano P, Kiely C, Mijalkov M, Meda S, Keedy S, Hoang D, Zeng V, Lutz O, Pereira J, Ivleva E, Volpe G, Xu Y, Lee A, Rubin L, Hill S, Clementz B, Tamminga C, Pearlson G, Sweeney J, Gershon E, Keshavan M, Bishop J. Peripheral inflammatory subgroup differences in anterior Default Mode network and multiplex functional network topology are associated with cognition in psychosis. Brain Behavior And Immunity 2023, 114: 3-15. PMID: 37506949, PMCID: PMC10592140, DOI: 10.1016/j.bbi.2023.07.014.Peer-Reviewed Original ResearchConceptsResting-state networksHealthy controlsInter-network connectivityWorse verbal fluencyAnterior default mode networkC-reactive proteinResting-state functional networksDefault mode network connectivityRight frontoparietal networkMode network connectivityWorse cognitive performanceResting-state fMRIDefault mode networkFunctional network topologyInflammatory signatureSystemic inflammationInflammatory subgroupIL-6Neuroanatomical alterationsPsychosis probandsCo-activation patternsPsychosis spectrum disordersNetwork dysfunctionMultiple comparison correctionClinical implications
2020
O2.6. DELUSIONS ASSOCIATED WITH ABNORMAL FRONTOSTRIATAL EFFECTIVE CONNECTIVITY IN A SPECTRAL DCM ANALYSIS OF RESTING STATE FMRI
Okuneye V, Clementz B, Gershon E, Keshavan M, McDowell J, Pearlson G, Tamminga C, Sweeney J, Keedy S. O2.6. DELUSIONS ASSOCIATED WITH ABNORMAL FRONTOSTRIATAL EFFECTIVE CONNECTIVITY IN A SPECTRAL DCM ANALYSIS OF RESTING STATE FMRI. Schizophrenia Bulletin 2020, 46: s5-s5. PMCID: PMC7234244, DOI: 10.1093/schbul/sbaa028.011.Peer-Reviewed Original ResearchR-DLPFCEffective connectivityState effective connectivityDelusional severityPrefrontal cortexState fMRIRight dorsolateral prefrontal cortexVentrolateral prefrontal cortexDynamic causal modelingDorsolateral prefrontal cortexSignificant effective connectivityEffective connectivity resultsEffective connectivity differencesSpectral dynamic causal modelingResting-state fMRISubcortical brain regionsIntermediate Phenotypes (B-SNIP) studyNeurocognitive processesFMRI studyFrontostriatal connectivityPrediction errorVLPFCFalse beliefsDelusion severityDLPFC