Prediction and Classification of Alzheimer’s Disease Based on Combined Features From Apolipoprotein-E Genotype, Cerebrospinal Fluid, MR, and FDG-PET Imaging Biomarkers
Gupta Y, Lama R, Kwon G, Initiative A, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Khachaturian Z, Sorensen G, Carrillo M, Kuller L, Raichle M, Paul S, Davies P, Fillit H, Hefti F, Holtzman D, Mesulam M, Potter W, Snyder P, Schwartz A, Green R, Montine T, Petersen R, Aisen P, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Balasubramanian A, Mason J, Sim I, Beckett L, Harvey D, Donohue M, Jack C, Bernstein M, Fox N, Thompson P, Schuff N, DeCArli C, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Morris J, Cairns N, Franklin E, Taylor-Reinwald L, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Weiner M, Thal L, Khachaturian Z, Thal L, Buckholtz N, Weiner M, Snyder P, Potter W, Paul S, Albert M, Frank R, Khachaturian Z, Hsiao J, Kaye J, Quinn J, Silbert L, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Villanueva-Meyer J, Pavlik V, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Creech M, Franklin E, Mintun M, Schneider S, Oliver A, Marson D, Geldmacher D, Love M, Griffith R, Clark D, Brockington J, Roberson E, Grossman H, Mitsis E, Shah R, deToledo-Morrell L, Duara R, Greig-Custo M, Barker W, Albert M, Onyike C, D'Agostino D, Kielb S, Sadowski M, Sheikh M, Anaztasia U, Mrunalini G, Doraiswamy P, Petrella J, Borges-Neto S, Wong T, Coleman E, Arnold S, Karlawish J, Wolk D, Clark C, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Potkin S, Preda A, Nguyen D, Womack K, Mathews D, Quiceno M, Levey A, Lah J, Cellar J, Burns J, Swerdlow R, Brooks W, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Graff-Radford N, Parfitt F, Poki-Walker K, Farlow M, Hake A, Matthews B, Brosch J, Herring S, van Dyck C, Carson R, MacAvoy M, Varma P, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Mudge B, Sossi V, Feldman H, Assaly M, Finger E, Pasternack S, Rachisky I, Trost D, Kertesz A, Bernick C, Munic D, Mesulam M, Rogalski E, Lipowski K, Weintraub S, Bonakdarpour B, Kerwin D, Wu C, Johnson N, Sadowsky C, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Fletcher E, Maillard P, Olichney J, DeCarli C, Carmichael O, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Burke A, Milliken A, Trncic N, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Kelley B, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Sink K, Leslie G, Williamson J, Garg P, Watkins F, Ott B, Tremont G, Daiello L, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Perry D, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Smith K, Koleva H, Nam K, Shim H, Relkin N, Chiang G, Lin M, Ravdin L, Smith A, Raj B, Fargher K, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Green R, Harvey D, Jack C, Jagust W, Morris J, Saykin A, Shaw L, Toga A, Trojanowki J, Neylan T, Grafman J, Green R, Montine T, Weiner M, Petersen R, Aisen P, Thomas R, Donohue M, Devon G, Sather T, Melissa D, Morrison R, Jiminez G, Neylan T, Jacqueline H, Shannon F, Harvey D, Donohue M, Jack C, Bernstein M, Borowski B, Gunter J, Senjem M, Kejal K, Chad W, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Landau S, Morris J, Cairns N, Householder E, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Karen C, Scott N, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Weiner M, Karl F, Schneider L, Pawluczyk S, Mauricio B, Brewer J, Vanderswag H, Stern Y, Honig L, Bell K, Fleischman D, Arfanakis K, Shah R, Duara R, Varon D, Greig M, Doraiswamy P, Petrella J, James O, Porsteinsson A, Goldstein B, Martin K, Potkin S, Preda A, Nguyen D, Mintzer J, Massoglia D, Brawman-Mintzer O, Sadowsky C, Martinez W, Villena T, Jagust W, Landau S, Rosen H, Perry D, Turner R, Behan K, Reynolds B, Sperling R, Johnson K, Marshall G, Sabbagh M, Jacobson S, Sirrel S, Obisesan T, Wolday S, Allard J, Johnson S, Fruehling J, Harding S, Peskind E, Petrie E, Li G, Yesavage J, Taylor J, Furst A, Chao S, Relkin N, Chiang G, Ravdin L, Ravdin L, Mackin S, Aisen P, Raman R, Mackin S, Weiner M, Aisen P, Raman R, Jack C, Landau S, Saykin A, Toga A, DeCarli C, Koeppe R, Green R, Drake E, Weiner M, Aisen P, Raman R, Donohue M, Jimenez G, Gessert D, Harless K, Salazar J, Cabrera Y, Walter S, Hergesheimer L, Shaffer E, Mackin S, Nelson C, Bickford D, Butters M, Zmuda M, Jack C, Bernstein M, Borowski B, Gunter J, Senjem M, Kantarci K, Ward C, Reyes D, Koeppe R, Landau S, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Faber K, Nho K, Nudelman K, Mackin S, Rosen H, Nelson C, Bickford D, Au Y, Scherer K, Catalinotto D, Stark S, Ong E, Fernandez D, Butters M, Zmuda M, Lopez O, Oakley M, Simpson D. Prediction and Classification of Alzheimer’s Disease Based on Combined Features From Apolipoprotein-E Genotype, Cerebrospinal Fluid, MR, and FDG-PET Imaging Biomarkers. Frontiers In Computational Neuroscience 2019, 13: 72. PMID: 31680923, PMCID: PMC6805777, DOI: 10.3389/fncom.2019.00072.Peer-Reviewed Original ResearchStructural magnetic resonance imagingApolipoprotein E genotypeAlzheimer's diseaseCerebrospinal fluid protein levelsFluorodeoxyglucose positron emission tomographyDifferent biomarkersDiagnosis of ADHealthy control groupMagnetic resonance imagingPositron emission tomographyDisease BasedAD groupCerebrospinal fluidMCI stageMild cognitive impairment phaseControl groupMCI subjectsImaging biomarkersResonance imagingADNI websiteEmission tomographyAlzheimer’s Disease BasedMCI groupBiomarkersProtein levelsQuantitative 18F-AV1451 Brain Tau PET Imaging in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer's Disease Patients
Zhao Q, Liu M, Ha L, Zhou Y, Initiative A, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Khachaturian Z, Sorensen G, Carrillo M, Kuller L, Raichle M, Paul S, Davies P, Fillit H, Hefti F, Holtzman D, Mesulam M, Potter W, Snyder P, Schwartz A, Green R, Montine T, Petersen R, Aisen P, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Balasubramanian A, Mason J, Sim I, Beckett L, Harvey D, Donohue M, Jack C, Bernstein M, Fox N, Thompson P, Schuff N, DeCArli C, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Morris J, Cairns N, Franklin E, Taylor-Reinwald L, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Weiner M, Thal L, Khachaturian Z, Thal L, Buckholtz N, Weiner M, Snyder P, Potter W, Paul S, Albert M, Frank R, Khachaturian Z, Hsiao J, Kaye J, Quinn J, Silbert L, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Villanueva-Meyer J, Pavlik V, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Creech M, Franklin E, Mintun M, Schneider S, Oliver A, Marson D, Geldmacher D, Love M, Griffith R, Clark D, Brockington J, Roberson E, Grossman H, Mitsis E, Shah R, deToledo-Morrell L, Duara R, Greig-Custo M, Barker W, Albert M, Onyike C, D'Agostino D, Kielb S, Sadowski M, Sheikh M, Anaztasia U, Mrunalini G, Doraiswamy P, Petrella J, Borges-Neto S, Wong T, Coleman E, Arnold S, Karlawish J, Wolk D, Clark C, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Potkin S, Preda A, Nguyen D, Womack K, Mathews D, Quiceno M, Levey A, Lah J, Cellar J, Burns J, Swerdlow R, Brooks W, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Graff-Radford N, Parfitt F, Poki-Walker K, Farlow M, Hake A, Matthews B, Brosch J, Herring S, van Dyck C, Carson R, MacAvoy M, Varma P, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Mudge B, Sossi V, Feldman H, Assaly M, Finger E, Pasternack S, Rachisky I, Trost D, Kertesz A, Bernick C, Munic D, Mesulam M, Rogalski E, Lipowski K, Weintraub S, Bonakdarpour B, Kerwin D, Wu C, Johnson N, Sadowsky C, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Fletcher E, Maillard P, Olichney J, DeCarli C, Carmichael O, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Burke A, Milliken A, Trncic N, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Kelley B, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Sink K, Leslie G, Williamson J, Garg P, Watkins F, Ott B, Tremont G, Daiello L, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Perry D, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Smith K, Koleva H, Nam K, Shim H, Relkin N, Chiang G, Lin M, Ravdin L, Smith A, Raj B, Fargher K, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Green R, Harvey D, Jack C, Jagust W, Morris J, Saykin A, Shaw L, Toga A, Trojanowki J, Neylan T, Grafman J, Green R, Montine T, Weiner M, Petersen R, Aisen P, Thomas R, Donohue M, Devon G, Sather T, Melissa D, Morrison R, Jiminez G, Neylan T, Jacqueline H, Shannon F, Harvey D, Donohue M, Jack C, Bernstein M, Borowski B, Gunter J, Senjem M, Kejal K, Chad W, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Landau S, Morris J, Cairns N, Householder E, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Karen C, Scott N, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Weiner M, Karl F, Schneider L, Pawluczyk S, Mauricio B, Brewer J, Vanderswag H, Stern Y, Honig L, Bell K, Fleischman D, Arfanakis K, Shah R, Duara R, Varon D, Greig M, Doraiswamy P, Petrella J, James O, Porsteinsson A, Goldstein B, Martin K, Potkin S, Preda A, Nguyen D, Mintzer J, Massoglia D, Brawman-Mintzer O, Sadowsky C, Martinez W, Villena T, Jagust W, Landau S, Rosen H, Perry D, Turner R, Behan K, Reynolds B, Sperling R, Johnson K, Marshall G, Sabbagh M, Jacobson S, Sirrel S, Obisesan T, Wolday S, Allard J, Johnson S, Fruehling J, Harding S, Peskind E, Petrie E, Li G, Yesavage J, Taylor J, Furst A, Chao S, Relkin N, Chiang G, Ravdin L, Ravdin L, Mackin S, Aisen P, Raman R, Mackin S, Weiner M, Aisen P, Raman R, Jack C, Landau S, Saykin A, Toga A, DeCarli C, Koeppe R, Green R, Drake E, Weiner M, Aisen P, Raman R, Donohue M, Jimenez G, Gessert D, Harless K, Salazar J, Cabrera Y, Walter S, Hergesheimer L, Shaffer E, Mackin S, Nelson C, Bickford D, Butters M, Zmuda M, Jack C, Bernstein M, Borowski B, Gunter J, Senjem M, Kantarci K, Ward C, Reyes D, Koeppe R, Landau S, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Faber K, Nho K, Nudelman K, Mackin S, Rosen H, Nelson C, Bickford D, Au Y, Scherer K, Catalinotto D, Stark S, Ong E, Fernandez D, Butters M, Zmuda M, Lopez O, Oakley M, Simpson D. Quantitative 18F-AV1451 Brain Tau PET Imaging in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer's Disease Patients. Frontiers In Neurology 2019, 10: 486. PMID: 31156534, PMCID: PMC6530456, DOI: 10.3389/fneur.2019.00486.Peer-Reviewed Original ResearchStandardized uptake value ratioMini-Mental State ExaminationTau positron emission tomographyPositron emission tomographyMild cognitive impairmentCSF p-tauTau depositionNormal older adultsF-AV1451Cognitive impairmentF-AVAlzheimer's Disease Neuroimaging InitiativeBrain regionsP-tauDisease patientsSmall brain regionsDisease Neuroimaging InitiativeEntorhinal cortexMMSE scoresPET standardized uptake value ratioPartial volume correctionRegional standardized uptake value ratiosStructural MRIMCI groupOlder adults