1995
Heroin use during methadone maintenance treatment: the importance of methadone dose and cocaine use.
Hartel D, Schoenbaum E, Selwyn P, Kline J, Davenny K, Klein R, Friedland G. Heroin use during methadone maintenance treatment: the importance of methadone dose and cocaine use. American Journal Of Public Health 1995, 85: 83-88. PMID: 7832267, PMCID: PMC1615273, DOI: 10.2105/ajph.85.1.83.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentHeroin useMaintenance treatmentHigh-dose methadone maintenanceCocaine useMethadone dosage levelsNonusers of cocaineMethadone doseLogistic regression statistical modelMethadone dosageMethadone patientsTreatment complianceMethadone maintenanceIndependent associationTreatment durationCross-sectional samplePatientsAlcohol useDosage levelsCocaine usersSocioeconomic factorsTreatmentFurther investigationCocaineNonusers
1992
Pharmacokinetic interactions of zidovudine and methadone in intravenous drug-using patients with HIV infection.
Schwartz E, Brechbühl A, Kahl P, Miller M, Selwyn P, Friedland G. Pharmacokinetic interactions of zidovudine and methadone in intravenous drug-using patients with HIV infection. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1992, 5: 619-26. PMID: 1588496.Peer-Reviewed Original ResearchConceptsIntravenous drug usersControl patientsMethadone patientsPharmacokinetic parametersHigh-pressure liquid chromatographyFormer intravenous drug usersIntravenous drug-using patientsMethadone maintenance therapyDrug-using patientsConcentration-time curveHuman hepatic microsomesZDV levelsZDV therapyZDV treatmentMaintenance therapyMethadone concentrationsMethadone groupHIV infectionPharmacokinetic interactionsSerum levelsConcurrent administrationIVDU patientsUrinary excretionPatientsZidovudine