2023
A Comprehensive Primer on Radiation Oncology for Non-Radiation Oncologists
Beddok A, Lim R, Thariat J, Shih H, Fakhri G. A Comprehensive Primer on Radiation Oncology for Non-Radiation Oncologists. Cancers 2023, 15: 4906. PMID: 37894273, PMCID: PMC10605284, DOI: 10.3390/cancers15204906.Peer-Reviewed Original ResearchProton therapyRadiation therapyRadiation oncologistsIntensity-modulated proton therapyNon-oncologistsNon-radiation oncologistsImage-guided RTFollow-upExternal beam therapyArc therapyThree-dimensional conformal RTCT simulationPatient alignmentTarget volumeIntensity-modulated RTRT planningCompletion of RTPotential late effects of treatmentMedical physicistsLifelong follow-upLate effects of treatmentPatient follow-upBeam therapyNon-radiativeOptimize treatment outcomes
2015
Mapping 15O Production Rate for Proton Therapy Verification
Grogg K, Alpert N, Zhu X, Min C, Testa M, Winey B, Normandin M, Shih H, Paganetti H, Bortfeld T, Fakhri G. Mapping 15O Production Rate for Proton Therapy Verification. International Journal Of Radiation Oncology • Biology • Physics 2015, 92: 453-459. PMID: 25817530, PMCID: PMC4431894, DOI: 10.1016/j.ijrobp.2015.01.023.Peer-Reviewed Original ResearchConceptsDecay constantProton treatment planningMonte Carlo predictionsProton therapyPhantom materialTreatment deliveryPhantomThigh activityPositron emission tomographyProduction rateDynamic PET measurementsTreatment planningRabbit thigh muscleClearance rateProtonIsotopesChanges due to therapyRadionuclide speciesOxygen-15ConstantDecayImaging targetsMontePositronEffects of perfusion
2014
OC-0268: Uncertainties in PET-based range verification of pristine and spread-out Bragg peaks of clinical proton therapy
Liebl J, Testa M, Lu H, Winey B, Grogg K, Zhu X, Fakhri G, Paganetti H. OC-0268: Uncertainties in PET-based range verification of pristine and spread-out Bragg peaks of clinical proton therapy. Radiotherapy And Oncology 2014, 111: s103. DOI: 10.1016/s0167-8140(15)30373-x.Peer-Reviewed Original Research
2013
Feasibility of Using Distal Endpoints for In-Room PET Range Verification of Proton Therapy
Grogg K, Zhu X, Min C, Winey B, Bortfeld T, Paganetti H, Shih H, Fakhri G. Feasibility of Using Distal Endpoints for In-Room PET Range Verification of Proton Therapy. IEEE Transactions On Nuclear Science 2013, 60: 3290-3297. DOI: 10.1109/tns.2013.2278140.Peer-Reviewed Original ResearchPET distributionsNuclear reactionsProton therapyMC-PETSimulated positron emission tomographyIn-roomMonte CarloPET resolutionPositron emission tomographyRange verificationBiological washoutDose depthThreshold energyDose deliveryCross sectionPlanned doseMC simulationsIndividual beamsSimPETOne-dimensional profilesRadiological decayBeamDistal endpointsProtonNative nucleiFeasibility of using distal endpoints for In-room PET Range Verification of Proton Therapy
Grogg K, Zhu X, Min C, Winey B, Bortfeld T, Paganetti H, Shih H, El Fakhri G. Feasibility of using distal endpoints for In-room PET Range Verification of Proton Therapy. IEEE Transactions On Nuclear Science 2013, 60: 3890-3894. PMID: 24464031, PMCID: PMC3900284, DOI: 10.1109/nssmic.2012.6551892.Peer-Reviewed Original ResearchPET distributionsNuclear reactionsProton therapyMC-PETSimulated positron emission tomographyMonte CarloPET resolutionPositron emission tomographyRange verificationBiological washoutDose depthThreshold energyDose deliveryCross sectionPlanned doseMC simulationsIndividual beamsSimPETOne-dimensional profilesIn-roomRadiological decayBeamDistal endpointsProtonNative nucleiClinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy
Min C, Zhu X, Winey B, Grogg K, Testa M, Fakhri G, Bortfeld T, Paganetti H, Shih H. Clinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2013, 86: 183-189. PMID: 23391817, PMCID: PMC3640852, DOI: 10.1016/j.ijrobp.2012.12.010.Peer-Reviewed Original ResearchConceptsIn-room positron emission tomographyProton therapyIn-roomPositron emission tomography scanIn-room PET scannerPassive scattering proton therapyShapes of target volumesPositron emission tomographyMC predictionBeam range uncertaintiesMeasured PET imagesMonte CarloProton radiation therapyLocal elemental compositionBiological washoutScan timeTreatment headTreatment verificationRange uncertaintiesTarget volumePET scan timePET scannerPET systemComputed tomographyMC results
2012
MO‐A‐213AB‐07: Evaluation of Distal Dose Surface with In‐Room PET for Proton Therapy Monitoring
Min C, Zhu X, Grogg K, Winey B, Fakhri G, Bortfeld T, Shih H, Paganetti H. MO‐A‐213AB‐07: Evaluation of Distal Dose Surface with In‐Room PET for Proton Therapy Monitoring. Medical Physics 2012, 39: 3860-3860. PMID: 28517508, DOI: 10.1118/1.4735759.Peer-Reviewed Original ResearchProton dose distributionsMeasured PET imagesDose surfaceDose distributionIn-roomMonte CarloProton therapy monitoringBeam's eye viewPET activitySimulated PET imagesPET imagingGantry roomsTreatment verificationTreatment headBeam deliveryClinical trialsProton therapyPassive scatteringMC simulationsBeam directionTreated volumeRoot-mean-square deviationBeamImage registrationSimulated PET
2011
Monitoring proton radiation therapy with in-room PET imaging
Zhu X, España S, Daartz J, Liebsch N, Ouyang J, Paganetti H, Bortfeld T, Fakhri G. Monitoring proton radiation therapy with in-room PET imaging. Physics In Medicine And Biology 2011, 56: 4041-4057. PMID: 21677366, PMCID: PMC3141290, DOI: 10.1088/0031-9155/56/13/019.Peer-Reviewed Original ResearchConceptsIn-room positron emission tomographyIn-roomProton therapy treatment roomPositron emission tomography systemProton range verificationSoft tissue-equivalent materialMonte Carlo predictionsTissue-equivalent materialsPositron emission tomography acquisition timesProton radiation therapyPositron emission tomographyBiological washoutRange verificationProton therapyList-modeActivity distribution patternsPhantom studyTreatment roomPET acquisitionSoft tissue regionsIn vivo verificationDeep-siteOff-line modalityPositron emission tomography dataAdenoid cystic carcinoma