2014
4D numerical observer for lesion detection in respiratory‐gated PET
Lorsakul A, Li Q, Trott C, Hoog C, Petibon Y, Ouyang J, Laine A, Fakhri G. 4D numerical observer for lesion detection in respiratory‐gated PET. Medical Physics 2014, 41: 102504. PMID: 25281979, PMCID: PMC4281099, DOI: 10.1118/1.4895975.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsComputer SimulationFluorodeoxyglucose F18HumansImage Interpretation, Computer-AssistedLung DiseasesModels, BiologicalMonte Carlo MethodMotionPhantoms, ImagingPositron-Emission TomographyRadiopharmaceuticalsRegression AnalysisRespiratory-Gated Imaging TechniquesSignal-To-Noise RatioConceptsRespiratory-gated positron emission tomographyMotion-corrected imagesDetection signal-to-noise ratioLesion detection taskNumerical observationsLesion detection performanceSignal-to-noise ratioPositron emission tomography sinogramsSpherical lesionsHotelling observerMotion correction methodPositron emission tomographyGeant4 ApplicationTomographic EmissionChannelized Hotelling observerAnthropomorphic phantomScanner geometryOSEM algorithmMonte Carlo simulationsPET framesImprove lesion detectionLesion detectionSignal-to-noise ratio measurementsActivity distributionConventional 3D approach
2011
Impact of Time-of-Flight PET on Whole-Body Oncologic Studies: A Human Observer Lesion Detection and Localization Study
Surti S, Scheuermann J, Fakhri G, Daube-Witherspoon M, Lim R, Abi-Hatem N, Moussallem E, Benard F, Mankoff D, Karp J. Impact of Time-of-Flight PET on Whole-Body Oncologic Studies: A Human Observer Lesion Detection and Localization Study. Journal Of Nuclear Medicine 2011, 52: 712-719. PMID: 21498523, PMCID: PMC3104282, DOI: 10.2967/jnumed.110.086678.Peer-Reviewed Original ResearchConceptsLocalization receiver operating characteristicsTime-of-flight PETLong scan timesArea under the LROC curveScan timeFunction of scan timePatient sizeTime-of-flight (TOFLROC curveLow-uptake lesionsTOF imagesTOF kernelLesion detection taskTOF-PETWhole-body oncologyLesion detection performanceScanner fieldPhantom studyPatient body mass indexProbability of correct localizationLesion detectionSphere dataBody mass indexLarger patientsReceiver operating characteristic
2006
Optimizing Acquisition Parameters in TOF PET Scanners
Surti S, El-Fakhri G, Karp J. Optimizing Acquisition Parameters in TOF PET Scanners. 2006, 4: 2354-2359. DOI: 10.1109/nssmic.2006.354386.Peer-Reviewed Original ResearchNoise equivalent countCho SNRNon-TOF scannerScan timePET image qualityPatient dosageTime-of-flightSingles ratesOptimal acquisition parametersPET scannerTOF scannerDiameter cylinderIncreasing scan timeImage qualityReduce scan timeMeasure of signal-to-noise ratioSignal-to-noise ratioSpatial resolutionSNRAcquisition parametersLesion detectionLesionsTOFCylinderIncreased activity
2003
Evaluation of a Monte Carlo Scatter Correction in Clinical 3D PET
Holdsworth C, Badawi R, Santos P, Van den Abbeele A, Hoffman E, Fakhri G. Evaluation of a Monte Carlo Scatter Correction in Clinical 3D PET. 2003, 4: 2540-2544. DOI: 10.1109/nssmic.2003.1352408.Peer-Reviewed Original ResearchScatter correctionUncorrected imagesPET imagingChannelized Hotelling observerHotelling observerPatient dataPatient imagesQuantitative accuracyLesion detection sensitivityPatient sizePhantomLesion sensitivityPatientsMonteLesionsLesion detectionCorrectionROI analysisIntensity varianceDetection sensitivityPETScatteringAverage absolute bias
2002
Optimal Parallel-Hole Collimation for Lesion Detection and Activity Estimation in Ga-67 Imaging
Moore S, Kijewski M, Fakhri G. Optimal Parallel-Hole Collimation for Lesion Detection and Activity Estimation in Ga-67 Imaging. 2002, 3: 1390-1392. DOI: 10.1109/nssmic.2002.1239580.Peer-Reviewed Original ResearchCollimator designMedium-energy (MESimulation of photon transportSignal-to-noise ratioParallel-hole collimatorDesign of collimatorsClinical imaging tasksGa-67Contaminating photonsField of nuclear medicineEnergy windowFixed energyPhoton transportOptimal collimatorCollimatorCommercial collimatorsStaging of lymphoma patientsHotelling observerGa-67 imagingNuclear medicine clinicsLesion detectionNuclear medicineDetectorActivity concentrationsResolution valuesImpact of Acquisition Geometry and Patient Habitus on Lesion Detectability in Whole-Body FDG-PET: A Channelized Hotelling Observer Study
Fakhri G, Holdsworth C, Badawi R, Santos P, Moore S, Van den Abbeele A, Kijewski M. Impact of Acquisition Geometry and Patient Habitus on Lesion Detectability in Whole-Body FDG-PET: A Channelized Hotelling Observer Study. 2002, 3: 1402-1405. DOI: 10.1109/nssmic.2002.1239583.Peer-Reviewed Original ResearchBed positionChannelized Hotelling observer studyFDG-PET studiesAttenuation mapAcquisition modeMarginal detectionFDG-PETLesion detectionWhole-body FDG-PETHotelling observerScaling 2DTypical sizePatient sizeHours post-injectionPatient habitusAnatomical backgroundWhole bodyLesion sizeObservational studyPatientsLesionsLesion siteModePost-injectionAcquisition geometry