2024
Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP
Zhou Y, Wilks M, Dhaynaut M, Guehl N, Vesper D, Moon S, Rice P, El Fakhri G, Normandin M, Brugarolas P. Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP. EJNMMI Research 2024, 14: 43. PMID: 38683467, PMCID: PMC11058135, DOI: 10.1186/s13550-024-01092-8.Peer-Reviewed Original ResearchRadiation dosimetryAverage effective doseWhole-body biodistributionTotal scan timeNon-decayEffective doseNon-human primatesSymptomatic treatment of multiple sclerosisIn vivo binding affinityBed positionTreatment of multiple sclerosisHigh-resolution CTDynamic acquisition protocolDosimetryPET dataAdult rhesus macaquesScan timeImaging demyelinationOLINDA softwareRadiationAcquisition protocolsPreclinical studiesNo significant changesHigh dosesPET imaging
2022
Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP
Brugarolas P, Wilks M, Noel J, Kaiser J, Vesper D, Ramos-Torres K, Guehl N, Macdonald-Soccorso M, Sun Y, Rice P, Yokell D, Lim R, Normandin M, El Fakhri G. Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 50: 344-351. PMID: 36197499, PMCID: PMC9816249, DOI: 10.1007/s00259-022-05980-w.Peer-Reviewed Original ResearchConceptsRadiation dosimetryTime-activity curvesAdverse eventsEffective doseMultiple bed positionsComprehensive metabolic panelNonhuman primatesHealthy human volunteersNo adverse eventsDynamic PET scansVoltage-gated potassiumAnimal models of neurological diseasesNonhuman primate studiesModels of neurological diseasesHuman biodistributionAverage effective doseMetabolic panelDosimetryOLINDA softwareHealthy volunteersUrinary bladderPET scansDemyelinating lesionsBed positionAnimal models
2007
Impact of Acquisition Geometry, Image Processing, and Patient Size on Lesion Detection in Whole-Body 18F-FDG PET
Fakhri G, Santos P, Badawi R, Holdsworth C, Van Den Abbeele A, Kijewski M. Impact of Acquisition Geometry, Image Processing, and Patient Size on Lesion Detection in Whole-Body 18F-FDG PET. Journal Of Nuclear Medicine 2007, 48: 1951-1960. PMID: 18006613, DOI: 10.2967/jnumed.108.007369.Peer-Reviewed Original ResearchConceptsAttenuation-weighted OSEMOrdered-subset expectation maximizationNoise equivalent countPhantom sizeBed positionCho SNRPatient sizeFourier rebinningAttenuation mapPET scannerLesion detectionMarginal detectionTransmission scanWhole-body (18)F-FDG PETAttenuation correctionWhole-body 18F-FDG PETHotelling observerScaling 2DSinogramReconstructed volumeDetection SNRPhantomSystematic improvementFBPScattering
2002
Impact of Acquisition Geometry and Patient Habitus on Lesion Detectability in Whole-Body FDG-PET: A Channelized Hotelling Observer Study
Fakhri G, Holdsworth C, Badawi R, Santos P, Moore S, Van den Abbeele A, Kijewski M. Impact of Acquisition Geometry and Patient Habitus on Lesion Detectability in Whole-Body FDG-PET: A Channelized Hotelling Observer Study. 2002, 3: 1402-1405. DOI: 10.1109/nssmic.2002.1239583.Peer-Reviewed Original ResearchBed positionChannelized Hotelling observer studyFDG-PET studiesAttenuation mapAcquisition modeMarginal detectionFDG-PETLesion detectionWhole-body FDG-PETHotelling observerScaling 2DTypical sizePatient sizeHours post-injectionPatient habitusAnatomical backgroundWhole bodyLesion sizeObservational studyPatientsLesionsLesion siteModePost-injectionAcquisition geometry
2000
Relative lesion detectability in 3D vs. 2D dedicated multi-ring PET
Moore S, Fakhri G, Badawi R, Van den Abbeele A, Zimmerman R. Relative lesion detectability in 3D vs. 2D dedicated multi-ring PET. 2011 IEEE Nuclear Science Symposium Conference Record 2000, 3: 17/18-17/22 vol.3. DOI: 10.1109/nssmic.2000.949192.Peer-Reviewed Original ResearchField of viewNon-prewhiteningAxial field-of-viewMaximum ring differenceAnthropomorphic torso phantomClinically realistic phantomDetection of spheresNPW-SNRTorso phantomGe-68Head phantomDetection signal-to-noise ratioRing differenceRealistic phantomsPhantomBed positionF-18Signal-to-noise ratioActivity concentrationsTwo-dimensionalContrast levelsPET imagingCompare two-dimensionalModeFORE+FBP