1993
Amphetamine derivatives interact with both plasma membrane and secretory vesicle biogenic amine transporters.
Schuldiner S, Steiner-Mordoch S, Yelin R, Wall S, Rudnick G. Amphetamine derivatives interact with both plasma membrane and secretory vesicle biogenic amine transporters. Molecular Pharmacology 1993, 44: 1227-31. PMID: 7903417.Peer-Reviewed Original ResearchMeSH Keywords3,4-MethylenedioxyamphetamineAnimalsBlood PlateletsCarrier ProteinsCattleCell MembraneChromaffin GranulesFenfluramineHumansIn Vitro TechniquesMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsN-Methyl-3,4-methylenedioxyamphetamineP-ChloroamphetamineReserpineSerotoninSerotonin Plasma Membrane Transport ProteinsConceptsVesicular amine transporterVesicular amine transportAmine transportersAmine transportSerotonin transportChromaffin granule membrane vesiclesPlasma membrane transportersBiogenic amine transportersPlasma membraneMembrane transportersMembrane vesiclesSubstrate siteVesicular transportersTransportersDelta pHBinding of the cocaine analog 2 beta-carbomethoxy-3 beta-(4-[125I]iodophenyl)tropane to serotonin and dopamine transporters: different ionic requirements for substrate and 2 beta-carbomethoxy-3 beta-(4-[125I]iodophenyl)tropane binding.
Wall S, Innis R, Rudnick G. Binding of the cocaine analog 2 beta-carbomethoxy-3 beta-(4-[125I]iodophenyl)tropane to serotonin and dopamine transporters: different ionic requirements for substrate and 2 beta-carbomethoxy-3 beta-(4-[125I]iodophenyl)tropane binding. Molecular Pharmacology 1993, 43: 264-70. PMID: 8429827.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveBlood PlateletsCarrier ProteinsCocaineCorpus StriatumDopamineDopamine Plasma Membrane Transport ProteinsHydrogen-Ion ConcentrationIn Vitro TechniquesIonsMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsOsmolar ConcentrationProtein BindingRadioligand AssayRatsSerotoninSerotonin Plasma Membrane Transport ProteinsNon-neurotoxic amphetamine derivatives release serotonin through serotonin transporters.
Rudnick G, Wall S. Non-neurotoxic amphetamine derivatives release serotonin through serotonin transporters. Molecular Pharmacology 1993, 43: 271-6. PMID: 8429828.Peer-Reviewed Original ResearchMeSH KeywordsAmphetaminesBlood PlateletsCarrier ProteinsCell MembraneChromaffin GranulesHumansImipramineIn Vitro TechniquesIndansMembrane GlycoproteinsMembrane Transport ProteinsMethamphetamineModels, BiologicalNerve EndingsNerve Tissue ProteinsRadioligand AssaySerotoninSerotonin Plasma Membrane Transport ProteinsConceptsChromaffin granule membrane vesiclesPlasma membrane vesiclesMembrane vesiclesPlatelet plasma membrane vesiclesPlasma membrane transportersSerotonin transportBiogenic amine transportersMembrane transportersAmine transportersTransportersVesiclesDopamine transporterSerotonin transporterModel systemHalf-maximal concentrationNerve terminalsTransmembraneCocaine analogBindingSimilar concentrationsHigh concentrationsCellsTransport
1992
The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release.
Rudnick G, Wall S. The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 1817-1821. PMID: 1347426, PMCID: PMC48544, DOI: 10.1073/pnas.89.5.1817.Peer-Reviewed Original ResearchConceptsPlasma membrane vesiclesMembrane vesiclesAmine transportersVesicular amine transporterBiogenic amine transportersSecretory vesiclesPlasma membraneATP hydrolysisMolecular mechanismsBovine adrenal chromaffin granulesSerotonin transporterAdrenal chromaffin granulesTransportersDirect interactionVesiclesChromaffin granulesHuman plateletsManner characteristicEffluxTransmembraneATPMDMA actionMechanismBindingMembrane
1989
2-Iodoimipramine, a novel ligand for the serotonin transporter.
Humphreys C, Cassel D, Rudnick G. 2-Iodoimipramine, a novel ligand for the serotonin transporter. Molecular Pharmacology 1989, 36: 620-6. PMID: 2811859.Peer-Reviewed Original Research
1988
Antidepressant binding to the porcine and human platelet serotonin transporters.
Humphreys C, Levin J, Rudnick G. Antidepressant binding to the porcine and human platelet serotonin transporters. Molecular Pharmacology 1988, 33: 657-63. PMID: 3380080.Peer-Reviewed Original Research
1983
Sodium ion requirements for serotonin transport and imipramine binding.
Rudnick G, Talvenheimo J, Fishkes H, Nelson P. Sodium ion requirements for serotonin transport and imipramine binding. Psychopharmacology Bulletin 1983, 19: 545-9. PMID: 6635128.Peer-Reviewed Original Research
1981
Inhibition of platelet serotonin transport by propranolol.
Rudnick G, Bencuya R, Nelson P, Zito R. Inhibition of platelet serotonin transport by propranolol. Molecular Pharmacology 1981, 20: 118-23. PMID: 7290078.Peer-Reviewed Original Research