2016
Case of a Missed Giant Cell Tumor of Bone: An Opportunity to Observe its Natural History Disease.
Russo GS, Rubio DR, Yacob A, Lindskog DM, Alomari AK, Friedlaender GE. Case of a Missed Giant Cell Tumor of Bone: An Opportunity to Observe its Natural History Disease. Connecticut Medicine 2016, 80: 399-403. PMID: 29782126.Peer-Reviewed Case Reports and Technical NotesConceptsGiant cell tumorAnterior cruciate ligamentCell tumorsIncidental findingRoutine preoperative imagingPre-operative MRIInitial MRIPreoperative imagingSecond MRIMetaphyseal lesionsCruciate ligamentEnlarged massBenign neoplasmsRetrospective evaluationNatural historyTumorsYoung womenHistory diseaseMRIBoneLesionsPainPatientsNeoplasmsHistology
2003
Malignant bone tumors: limb sparing versus amputation.
DiCaprio MR, Friedlaender GE. Malignant bone tumors: limb sparing versus amputation. Journal Of The American Academy Of Orthopaedic Surgeons 2003, 11: 25-37. PMID: 12699369, DOI: 10.5435/00124635-200301000-00005.Peer-Reviewed Original ResearchConceptsLimb-sparing proceduresAppropriate surgical alternativesFunctional outcome studiesMainstay of treatmentExtent of diseaseAllograft-prosthetic compositeMalignant bone tumorsImportant outcome measureEffective chemotherapeutic agentLimb sparingMost patientsPatient ageReconstructed limbExpandable prosthesisSurgical alternativeTumor locationBone tumorsReconstructive surgeryOutcome measuresOutcome studiesSatisfactory functionModular endoprosthesesSurvival rateBone graftChemotherapeutic agents
2001
Osteogenic Protein-1 Overcomes the Inhibitory Effect of Nicotine on Posterolateral Lumbar Fusion
Patel T, Erulkar J, Grauer J, Troiano N, Panjabi M, Friedlaender G. Osteogenic Protein-1 Overcomes the Inhibitory Effect of Nicotine on Posterolateral Lumbar Fusion. Spine 2001, 26: 1656-1661. PMID: 11474350, DOI: 10.1097/00007632-200108010-00004.Peer-Reviewed Original ResearchConceptsPosterolateral lumbar fusionOsteogenic protein-1Inhibitory effectProtein 1Lumbar fusionRabbit posterolateral lumbar fusion modelRabbit posterolateral spine fusion modelFusion massRabbit modelSubcutaneous mini-osmotic pumpsPosterolateral lumbar fusion modelMini-osmotic pumpsNew Zealand white rabbitsNew Zealand white rabbit modelZealand white rabbitsPosterolateral spine fusionSpine fusion modelPosterolateral intertransverse process fusionWhite rabbit modelPresence of nicotineIntertransverse process fusionBone graft alternativesBony fusionBACKGROUND DATASpine fusionOP-1 clinical studies.
Friedlaender G. OP-1 clinical studies. Journal Of Bone And Joint Surgery 2001, 83-A Suppl 1: s160-1. PMID: 11314795, DOI: 10.2106/00004623-200100002-00012.Peer-Reviewed Original ResearchBone Morphogenetic Protein 2Bone Morphogenetic Protein 7Bone Morphogenetic ProteinsBone TransplantationChemokine CX3CL1Chemokines, CX3CChemokines, CXCFracture Fixation, IntramedullaryFractures, UnunitedHumansMembrane ProteinsRandomized Controlled Trials as TopicTibial FracturesTransforming Growth Factor betaOsteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions.
Friedlaender GE, Perry CR, Cole JD, Cook SD, Cierny G, Muschler GF, Zych GA, Calhoun JH, LaForte AJ, Yin S. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. Journal Of Bone And Joint Surgery 2001, 83-A Suppl 1: s151-8. PMID: 11314793, PMCID: PMC1425155, DOI: 10.2106/00004623-200100002-00010.Peer-Reviewed Original ResearchMeSH KeywordsAdultBone Morphogenetic Protein 7Bone Morphogenetic ProteinsBone TransplantationCollagenDrug CarriersDrug Delivery SystemsFemaleFracture Fixation, IntramedullaryFracture HealingFractures, UnunitedHumansMaleProspective StudiesRadiographyRecombinant ProteinsTibial FracturesTransforming Growth Factor betaConceptsTibial nonunionAdverse eventsRadiographic resultsClinical trialsOsteogenic protein-1Bone autograftAutogenous boneChronic donor site painAutograft-treated patientsFresh autogenous bonePlain radiographic evaluationMulti-center clinical trialPercent of patientsSeverity of painDonor site painGroup of patientsProtein 1Bone morphogenetic proteinNumerous animal modelsInvestigational device exemptionDonor site morbiditySame time pointsType ISite painClinical courseEvaluation of OP-1 as a Graft Substitute for Intertransverse Process Lumbar Fusion
Grauer J, Patel T, Erulkar J, Troiano N, Panjabi M, Friedlaender G. Evaluation of OP-1 as a Graft Substitute for Intertransverse Process Lumbar Fusion. Spine 2001, 26: 127-133. PMID: 11154530, DOI: 10.1097/00007632-200101150-00004.Peer-Reviewed Original ResearchConceptsIntertransverse process lumbar fusionIntertransverse process fusionManual palpationLumbar fusionOP-1Rabbit modelAutogenous iliac crest boneProcess fusionGraft substituteNew Zealand white rabbitsIliac crest boneOP-1 groupZealand white rabbitsMultidirectional flexibility testingAutograft specimensLess morbidityBiomechanical testing resultsCrest boneStudy groupAutograft groupBACKGROUND DATAFusion massWhite rabbitsL5-L6Bone graft substitute
2000
Appropriate screening for prevention of infection transmission by musculoskeletal allografts.
Friedlaender G. Appropriate screening for prevention of infection transmission by musculoskeletal allografts. Instructional Course Lectures 2000, 49: 615-9. PMID: 10829217.Peer-Reviewed Original Research
1999
LONG-TERM FOLLOW-UP OF PATIENTS WITH OSTEOCHONDRAL ALLOGRAFTS A Correlation Between Immunologic Responses and Clinical Outcome
Friedlaender G, Strong D, Tomford W, Mankin H. LONG-TERM FOLLOW-UP OF PATIENTS WITH OSTEOCHONDRAL ALLOGRAFTS A Correlation Between Immunologic Responses and Clinical Outcome. Orthopedic Clinics Of North America 1999, 30: 583-588. PMID: 10471763, DOI: 10.1016/s0030-5898(05)70111-5.Peer-Reviewed Original ResearchConceptsClinical outcomesImmunologic responseHistocompatibility antigensLong-term clinical outcomesLong-term resultsFrozen bone allograftsPresence of sensitizationFrozen osteochondral allograftsImmune responseBone allograftAnimal modelsSatisfactory outcomeOsteochondral allograftsReconstructive alternativeClass IIBiologic successAllograftsOutcomesAntigenResponsePatientsHumansSensitization
1992
Immune responses to osteochondral allografts: nature and significance.
Friedlaender G, Horowitz M. Immune responses to osteochondral allografts: nature and significance. Orthopedics 1992, 15: 1171-5. PMID: 1409127, DOI: 10.3928/0147-7447-19921001-08.Peer-Reviewed Original ResearchMeSH KeywordsAntibody FormationAntigens, SurfaceBone TransplantationCartilageHLA AntigensHumansIsoantigensConceptsImmune responseOsteochondral allograftsSuppressor/cytotoxic phenotypeBiologic significanceNumerous animal modelsT cell activationCell surface antigensMajor histocompatibility complexClinical resultsCytotoxic phenotypeBone allograftAnimal modelsSurface antigenBone graftAllograftsBiologic outcomesHistocompatibility complexCellular elementsGraftAntigenResponseImmunogenicitySignificanceBone graft and total hip arthroplasty A review
Huo M, Friedlaender G, Salvati E. Bone graft and total hip arthroplasty A review. The Journal Of Arthroplasty 1992, 7: 109-120. PMID: 1613516, DOI: 10.1016/0883-5403(92)90003-9.Peer-Reviewed Original ResearchMeSH KeywordsAcetabulumBone TransplantationFemaleFemurHip ProsthesisHIV InfectionsHumansMaleOsteonecrosisTissue DonorsTissue Preservation
1991
Induction of specific T-cell responsiveness to allogeneic bone.
Horowitz M, Friedlaender G. Induction of specific T-cell responsiveness to allogeneic bone. Journal Of Bone And Joint Surgery 1991, 73: 1157-68. PMID: 1716256, DOI: 10.2106/00004623-199173080-00004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, Differentiation, T-LymphocyteBone and BonesBone MarrowBone TransplantationCells, CulturedCytotoxicity Tests, ImmunologicEpitopesLymphocyte ActivationLymphocyte Culture Test, MixedMajor Histocompatibility ComplexMiceMice, Inbred StrainsT-LymphocytesTransplantation, HomologousTransplantation, IsogeneicConceptsT cellsAllogeneic boneMajor histocompatibility complexHistocompatibility complexAlloreactive T cellsClass II determinantsPurified T cellsSpecific immune responseT cell responsivenessMixed lymphocyte cultureCell surface phenotypeStrains of miceBone marrow cellsState of activationStimulating antigenImmune responseBone donorsAntigen specificityBone marrowLymphocyte culturesSecondary exposurePrimed cellsResponding cellsAntigenBone
1988
Tissue transplantation: allocation and related issues.
Friedlaender G. Tissue transplantation: allocation and related issues. Transplantation Proceedings 1988, 20: 1017-21. PMID: 3279598.Peer-Reviewed Original Research
1987
Bone banking. In support of reconstructive surgery of the hip.
Friedlaender G. Bone banking. In support of reconstructive surgery of the hip. Clinical Orthopaedics And Related Research® 1987, 17-21. PMID: 3119268.Peer-Reviewed Original ResearchMeSH KeywordsBone TransplantationHumansInfection ControlInfectionsPreservation, BiologicalQuality ControlTissue BanksTissue DonorsEffects of Bone Graft and Electrical Stimulation on the Strength of Healing Bony Defects in Dogs
LINDSEY R, GROBMAN J, LEGGON R, PANJABI M, FRIEDLAENDER G. Effects of Bone Graft and Electrical Stimulation on the Strength of Healing Bony Defects in Dogs. Clinical Orthopaedics And Related Research® 1987, 222: 275-280. PMID: 3304757, DOI: 10.1097/00003086-198709000-00037.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaBone and BonesBone DiseasesBone TransplantationDogsElectric Stimulation TherapyOsteogenesisConceptsElectrical stimulationGroup IIBone graftGroup IBony defectsGroup IIIAutogenous cancellous bone graftCancellous bone graftImplantable stimulatorTorsional strengthCanine femurStandard defectsIntact femurStrength 20Bone graftingGraftConclusive dataStrengthStimulationStrength 4WeeksHealing defectsFemurDefectsBone grafts. The basic science rationale for clinical applications.
Friedlaender G. Bone grafts. The basic science rationale for clinical applications. Journal Of Bone And Joint Surgery 1987, 69: 786-90. PMID: 3298264, DOI: 10.2106/00004623-198769050-00026.Peer-Reviewed Original ResearchMethods of Banking Bone and Cartilage for Allograft Transplantation
Tomford W, Mankin H, Friedlaender G, Doppelt S, Gebhardt M. Methods of Banking Bone and Cartilage for Allograft Transplantation. Orthopedic Clinics Of North America 1987, 18: 241-247. PMID: 3550573, DOI: 10.1016/s0030-5898(20)30388-6.Peer-Reviewed Original ResearchAllogeneic Bone in the Treatment of Tumors, Trauma, and Congenital Anomalies of the Hand
Trumble T, Friedlaender G. Allogeneic Bone in the Treatment of Tumors, Trauma, and Congenital Anomalies of the Hand. Orthopedic Clinics Of North America 1987, 18: 301-310. PMID: 3550577, DOI: 10.1016/s0030-5898(20)30393-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultBone LengtheningBone NeoplasmsBone TransplantationChildHandHand Deformities, CongenitalHand InjuriesHumansRadiographyTransplantation, HomologousConceptsAllogeneic boneBone graftEarly motionAutogenous corticocancellous graftCongruent joint surfaceLarge osteochondral allograftsShorter hospital stayDonor site deficitMassive bone graftGraft donor sitesTubular graftSmall bone graftStrong cortical boneDonor siteAutogenous bone graftDonor site morbidityTreatment of tumorsHospital stayCortical graftsPediatric patientsFibular headHand therapyCorticocancellous graftHand injuriesInternal fixationImmunologic Aspects of Bone Transplantation A Rationale for Future Studies
Horowitz M, Friedlaender G. Immunologic Aspects of Bone Transplantation A Rationale for Future Studies. Orthopedic Clinics Of North America 1987, 18: 227-233. PMID: 2951639, DOI: 10.1016/s0030-5898(20)30386-2.Peer-Reviewed Original Research
1985
Bone banking and clinical applications.
Friedlaender G. Bone banking and clinical applications. Transplantation Proceedings 1985, 17: 99-104. PMID: 3907058.Peer-Reviewed Original ResearchCurrent Perspectives and Future Directions
BURWELL R, FRIEDLAENDER G, MANKIN H. Current Perspectives and Future Directions. Clinical Orthopaedics And Related Research® 1985, 197: 141-157. PMID: 3893825, DOI: 10.1097/00003086-198507000-00017.Peer-Reviewed Original Research