2003
Malignant bone tumors: limb sparing versus amputation.
DiCaprio MR, Friedlaender GE. Malignant bone tumors: limb sparing versus amputation. Journal Of The American Academy Of Orthopaedic Surgeons 2003, 11: 25-37. PMID: 12699369, DOI: 10.5435/00124635-200301000-00005.Peer-Reviewed Original ResearchMeSH KeywordsAmputation, SurgicalArthrodesisBone LengtheningBone NeoplasmsBone TransplantationHumansPostoperative ComplicationsProsthesis DesignProsthesis ImplantationTransplantation, HomologousConceptsLimb-sparing proceduresAppropriate surgical alternativesFunctional outcome studiesMainstay of treatmentExtent of diseaseAllograft-prosthetic compositeMalignant bone tumorsImportant outcome measureEffective chemotherapeutic agentLimb sparingMost patientsPatient ageReconstructed limbExpandable prosthesisSurgical alternativeTumor locationBone tumorsReconstructive surgeryOutcome measuresOutcome studiesSatisfactory functionModular endoprosthesesSurvival rateBone graftChemotherapeutic agents
2000
Appropriate screening for prevention of infection transmission by musculoskeletal allografts.
Friedlaender G. Appropriate screening for prevention of infection transmission by musculoskeletal allografts. Instructional Course Lectures 2000, 49: 615-9. PMID: 10829217.Peer-Reviewed Original Research
1999
LONG-TERM FOLLOW-UP OF PATIENTS WITH OSTEOCHONDRAL ALLOGRAFTS A Correlation Between Immunologic Responses and Clinical Outcome
Friedlaender G, Strong D, Tomford W, Mankin H. LONG-TERM FOLLOW-UP OF PATIENTS WITH OSTEOCHONDRAL ALLOGRAFTS A Correlation Between Immunologic Responses and Clinical Outcome. Orthopedic Clinics Of North America 1999, 30: 583-588. PMID: 10471763, DOI: 10.1016/s0030-5898(05)70111-5.Peer-Reviewed Original ResearchConceptsClinical outcomesImmunologic responseHistocompatibility antigensLong-term clinical outcomesLong-term resultsFrozen bone allograftsPresence of sensitizationFrozen osteochondral allograftsImmune responseBone allograftAnimal modelsSatisfactory outcomeOsteochondral allograftsReconstructive alternativeClass IIBiologic successAllograftsOutcomesAntigenResponsePatientsHumansSensitization
1991
Induction of specific T-cell responsiveness to allogeneic bone.
Horowitz M, Friedlaender G. Induction of specific T-cell responsiveness to allogeneic bone. Journal Of Bone And Joint Surgery 1991, 73: 1157-68. PMID: 1716256, DOI: 10.2106/00004623-199173080-00004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, Differentiation, T-LymphocyteBone and BonesBone MarrowBone TransplantationCells, CulturedCytotoxicity Tests, ImmunologicEpitopesLymphocyte ActivationLymphocyte Culture Test, MixedMajor Histocompatibility ComplexMiceMice, Inbred StrainsT-LymphocytesTransplantation, HomologousTransplantation, IsogeneicConceptsT cellsAllogeneic boneMajor histocompatibility complexHistocompatibility complexAlloreactive T cellsClass II determinantsPurified T cellsSpecific immune responseT cell responsivenessMixed lymphocyte cultureCell surface phenotypeStrains of miceBone marrow cellsState of activationStimulating antigenImmune responseBone donorsAntigen specificityBone marrowLymphocyte culturesSecondary exposurePrimed cellsResponding cellsAntigenBone
1989
Allograft incorporation: A biomechanical evaluation in a rat model
Pelker R, McKay J, Troiano N, Panjabi M, Friedlaender G. Allograft incorporation: A biomechanical evaluation in a rat model. Journal Of Orthopaedic Research® 1989, 7: 585-589. PMID: 2786956, DOI: 10.1002/jor.1100070417.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaFemurFractures, BoneFreezingRatsRats, Inbred LewRats, Inbred StrainsTransplantation, HomologousWound HealingConceptsLewis ratsLevel of freezingImmunologic responseSprague-Dawley rat femursRat modelImmune responseAllogeneic boneFresh allograftsOsteosynthesis siteBiomechanical evaluationBiomechanical testingBiologic responseSubsequent healingAllograftsRat femurRatsIntact boneBoneFemurSignificant levelsResponseTransplantationTransplantGraftWeeks
1987
Bone grafts. The basic science rationale for clinical applications.
Friedlaender G. Bone grafts. The basic science rationale for clinical applications. Journal Of Bone And Joint Surgery 1987, 69: 786-90. PMID: 3298264, DOI: 10.2106/00004623-198769050-00026.Peer-Reviewed Original ResearchMethods of Banking Bone and Cartilage for Allograft Transplantation
Tomford W, Mankin H, Friedlaender G, Doppelt S, Gebhardt M. Methods of Banking Bone and Cartilage for Allograft Transplantation. Orthopedic Clinics Of North America 1987, 18: 241-247. PMID: 3550573, DOI: 10.1016/s0030-5898(20)30388-6.Peer-Reviewed Original ResearchAllogeneic Bone in the Treatment of Tumors, Trauma, and Congenital Anomalies of the Hand
Trumble T, Friedlaender G. Allogeneic Bone in the Treatment of Tumors, Trauma, and Congenital Anomalies of the Hand. Orthopedic Clinics Of North America 1987, 18: 301-310. PMID: 3550577, DOI: 10.1016/s0030-5898(20)30393-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultBone LengtheningBone NeoplasmsBone TransplantationChildHandHand Deformities, CongenitalHand InjuriesHumansRadiographyTransplantation, HomologousConceptsAllogeneic boneBone graftEarly motionAutogenous corticocancellous graftCongruent joint surfaceLarge osteochondral allograftsShorter hospital stayDonor site deficitMassive bone graftGraft donor sitesTubular graftSmall bone graftStrong cortical boneDonor siteAutogenous bone graftDonor site morbidityTreatment of tumorsHospital stayCortical graftsPediatric patientsFibular headHand therapyCorticocancellous graftHand injuriesInternal fixationBiomechanical Aspects of Bone Autografts and Allografts
Pelker R, Friedlaender G. Biomechanical Aspects of Bone Autografts and Allografts. Orthopedic Clinics Of North America 1987, 18: 235-239. PMID: 3561975, DOI: 10.1016/s0030-5898(20)30387-4.Peer-Reviewed Original ResearchConceptsMechanical propertiesLarge torsional loadsLocal biomechanical environmentCompressive loadTorsional loadsFreeze-dried graftsFreeze-dried boneMechanical issuesBiomechanical responseLoadBiomechanical environmentBiomechanical aspectsBiomechanical perspectivePropertiesNormal biomechanicsFixation devicesBone graftDonor boneDevicesFrozen boneSkeletal reconstructionImmunologic Aspects of Bone Transplantation A Rationale for Future Studies
Horowitz M, Friedlaender G. Immunologic Aspects of Bone Transplantation A Rationale for Future Studies. Orthopedic Clinics Of North America 1987, 18: 227-233. PMID: 2951639, DOI: 10.1016/s0030-5898(20)30386-2.Peer-Reviewed Original Research
1985
Current Perspectives and Future Directions
BURWELL R, FRIEDLAENDER G, MANKIN H. Current Perspectives and Future Directions. Clinical Orthopaedics And Related Research® 1985, 197: 141-157. PMID: 3893825, DOI: 10.1097/00003086-198507000-00017.Peer-Reviewed Original Research
1984
Transplantation of Osteochondral Allografts
Friedlaender G, Mankin H. Transplantation of Osteochondral Allografts. Annual Review Of Medicine 1984, 35: 311-324. PMID: 6372659, DOI: 10.1146/annurev.me.35.020184.001523.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone NeoplasmsBone TransplantationCartilageHumansTissue BanksTissue DonorsTissue PreservationTransplantation ImmunologyTransplantation, AutologousTransplantation, HomologousConceptsOsteochondral allograftsMassive osteochondral allograftsExcellent clinical resultsLimb-sparing approachesClinical resultsSkeletal deficitsBone tumorsImmune responseNeoplastic disordersCartilage graftsAllograftsSatisfactory tissueGraftEffective boneTransplantationLesionsTumorsInfectionAntigenBiological significance
1983
Immune responses to osteochondral allografts. Current knowledge and future directions.
Friedlaender G. Immune responses to osteochondral allografts. Current knowledge and future directions. Clinical Orthopaedics And Related Research® 1983, 58-68. PMID: 6339143.Peer-Reviewed Original ResearchConceptsImmune responseReconstructive joint surgeryGraft recipientsAllograft immunogenicityAllograft successHistocompatibility antigensJoint surgeryAnimal modelsBone graftOsteochondral allograftsHuman recipientsBiomechanical factorsAllograftsImmunogenHeterogeneous cell typesPreliminary evidenceImmunogenicityRecipientsCell typesCurrent knowledgeMatter of speculationSkeletal tissuesTissuePotent sourceResponseFROZEN AND FREEZE-DRIED BONE GRAFTS
PELKER R, FRIEDLAENDER G, MARKHAM T. FROZEN AND FREEZE-DRIED BONE GRAFTS. Clinical Orthopaedics And Related Research® 1983, 174: 36-42. PMID: 6339142, DOI: 10.1097/00003086-198304000-00007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaBone and BonesBone TransplantationCattleFreeze DryingHumansRatsRats, Inbred StrainsTensile StrengthTissue PreservationTransplantation, Homologous
1978
Clinical Evaluation of Freezedried Bone Allografts in Periodontal Osseous Defects‐Part II
Sepe W, Bowers G, Lawrence J, Friedlaender G, Koch R. Clinical Evaluation of Freezedried Bone Allografts in Periodontal Osseous Defects‐Part II. The Journal Of Periodontology 1978, 49: 9-14. PMID: 340637, DOI: 10.1902/jop.1978.49.1.9.Peer-Reviewed Original Research
1977
The Impact of Tissue Banking on the Treatment of Musculoskeletal System Trauma
Friedlaender G, Sell K, Bond J. The Impact of Tissue Banking on the Treatment of Musculoskeletal System Trauma. Military Medicine 1977, 142: 858-861. PMID: 412124, DOI: 10.1093/milmed/142.11.858.Peer-Reviewed Original ResearchRole of Preserved Allografts in Neurosurgical Procedures
Friedlaender G, Sell K, Bond J. Role of Preserved Allografts in Neurosurgical Procedures. Military Medicine 1977, 142: 685-686. PMID: 408755, DOI: 10.1093/milmed/142.9.685.Peer-Reviewed Original ResearchBone TransplantationDura MaterHumansNeurosurgical ProceduresTissue PreservationTransplantation, HomologousTissue Banking: The United States Navy Tissue Bank
Bright R, Friedlaender G, Sell K. Tissue Banking: The United States Navy Tissue Bank. Military Medicine 1977, 142: 503-510. PMID: 407498, DOI: 10.1093/milmed/142.7.503.Peer-Reviewed Original Research
1976
The use of freeze-dried bone in middle-third face advancements
Epker B, Friedlaender G, Wolford L, West R. The use of freeze-dried bone in middle-third face advancements. Oral Surgery Oral Medicine Oral Pathology And Oral Radiology 1976, 42: 278-289. PMID: 787861, DOI: 10.1016/0030-4220(76)90161-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBone TransplantationChildFacial BonesFemaleFreeze DryingHumansMaleMaxillaRadiographySkullSurgical Wound InfectionTransplantation, HomologousWound HealingConceptsFreeze-dried bone allograftPrimary operative procedureFreeze-dried boneMedical Research InstituteNaval Medical Research InstituteSmall sequestrumAdditional surgeryOperative procedureClinical infectionBone allograftPatientsMaxillary areaAutogenous boneGraft materialInfectionTissue banksIntraoral exposureAllograftsBoneGraftMorbiditySequestrumComplicationsSurgeryOsteotomy