1980
Chemical modification reduces the conductance of sodium channels in nerve
Sigworth F, Spalding B. Chemical modification reduces the conductance of sodium channels in nerve. Nature 1980, 283: 293-295. PMID: 6965422, DOI: 10.1038/283293a0.Peer-Reviewed Original ResearchConceptsChemical modificationTrimethyloxonium ionSuch chemical modificationsCarboxyl groupsNegative chargeSuch reagentsTMO treatmentPermeability propertiesReagentsLinear instantaneous current-voltage relationshipSmaller single-channel conductancePropertiesPotent poisonNormal KdIonsModificationSaxitoxinCharge
1977
Sodium channels in nerve apparently have two conductance states
SIGWORTH F. Sodium channels in nerve apparently have two conductance states. Nature 1977, 270: 265-267. PMID: 593345, DOI: 10.1038/270265a0.Peer-Reviewed Original Research