1998
Activation of Shaker Potassium Channels
Schoppa N, Sigworth F. Activation of Shaker Potassium Channels. The Journal Of General Physiology 1998, 111: 295-311. PMID: 9450945, PMCID: PMC2222768, DOI: 10.1085/jgp.111.2.295.Peer-Reviewed Original ResearchActivation of Shaker Potassium Channels
Schoppa N, Sigworth F. Activation of Shaker Potassium Channels. The Journal Of General Physiology 1998, 111: 313-342. PMID: 9450946, PMCID: PMC2222769, DOI: 10.1085/jgp.111.2.313.Peer-Reviewed Original ResearchActivation of Shaker Potassium Channels
Schoppa N, Sigworth F. Activation of Shaker Potassium Channels. The Journal Of General Physiology 1998, 111: 271-294. PMID: 9450944, PMCID: PMC2222764, DOI: 10.1085/jgp.111.2.271.Peer-Reviewed Original Research
1995
Charge movement in the sodium channel.
Sigworth F. Charge movement in the sodium channel. The Journal Of General Physiology 1995, 106: 1047-1051. PMID: 8786349, PMCID: PMC2229309, DOI: 10.1085/jgp.106.6.1047.Peer-Reviewed Original ResearchDesign of the EPC-9, a computer-controlled patch-clamp amplifier. 1. Hardware
Sigworth F. Design of the EPC-9, a computer-controlled patch-clamp amplifier. 1. Hardware. Journal Of Neuroscience Methods 1995, 56: 195-202. PMID: 7538620, DOI: 10.1016/0165-0270(94)00128-4.Peer-Reviewed Original ResearchDesign of the EPC-9, a computer-controlled patch-clamp amplifier. 2. Software
Sigworth F, Affolter H, Neher E. Design of the EPC-9, a computer-controlled patch-clamp amplifier. 2. Software. Journal Of Neuroscience Methods 1995, 56: 203-215. PMID: 7538621, DOI: 10.1016/0165-0270(94)00129-5.Peer-Reviewed Original Research
1994
Oxygen deprivation activates an ATP-inhibitable K+ channel in substantia nigra neurons
Jiang C, Sigworth F, Haddad G. Oxygen deprivation activates an ATP-inhibitable K+ channel in substantia nigra neurons. Journal Of Neuroscience 1994, 14: 5590-5602. PMID: 8083755, PMCID: PMC6577106, DOI: 10.1523/jneurosci.14-09-05590.1994.Peer-Reviewed Original ResearchConceptsSubstantia nigra neuronsRat substantia nigra neuronsEffects of hypoxiaGlibenclamide binding sitesEffect of ATPCell-attached patchesNeuronal survivalKATP channelsResult of Ca2Different subtypesOutward currentsNeuronal structuresFree Ca2HypoxiaMetabolic stressNeuronsDeleterious changesSingle-channel currentsChannel activityO2 deprivationInternal ATPOxygen deprivationActivationHigh Ca2Membrane potential
1993
Functional consequences of a Na+ channel mutation causing hyperkalemic periodic paralysis
Cummins T, Zhou J, Sigworth F, Ukomadu C, Stephan M, Ptáčk L, Agnew W. Functional consequences of a Na+ channel mutation causing hyperkalemic periodic paralysis. Neuron 1993, 10: 667-678. PMID: 8386527, DOI: 10.1016/0896-6273(93)90168-q.Peer-Reviewed Original ResearchConceptsHyperkalemic periodic paralysisFifth transmembrane segmentHuman embryonic kidney 293 cellsSingle base pair substitutionsEmbryonic kidney 293 cellsKidney 293 cellsBase pair substitutionsTransmembrane segmentsHuman mutationsChannel cDNARat channelHuman skeletal muscleFunctional consequencesPair substitutionsSecond domainCorresponding regionChannel mutationsGenetic defectsMutationsSkeletal musclePeriodic paralysisPatch-clamp recordingsCDNARat musclePedigree
1990
Yet another approach to the dwell-time omission problem of single-channel analysis
Crouzy S, Sigworth F. Yet another approach to the dwell-time omission problem of single-channel analysis. Biophysical Journal 1990, 58: 731-743. PMID: 1698473, PMCID: PMC1281014, DOI: 10.1016/s0006-3495(90)82416-4.Peer-Reviewed Original Research
1981
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
Hamill O, Marty A, Neher E, Sakmann B, Sigworth F. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Archiv - European Journal Of Physiology 1981, 391: 85-100. PMID: 6270629, DOI: 10.1007/bf00656997.Peer-Reviewed Original Research