2014
Proteomic identification of 14‐3‐3ϵ as a linker protein between pERK1/2 inhibition and BIM upregulation in human osteosarcoma cells
Kim KO, Hsu AC, Lee HG, Patel N, Chandhanayingyong C, Hickernell T, Lee F. Proteomic identification of 14‐3‐3ϵ as a linker protein between pERK1/2 inhibition and BIM upregulation in human osteosarcoma cells. Journal Of Orthopaedic Research® 2014, 32: 848-854. PMID: 24536031, DOI: 10.1002/jor.22598.Peer-Reviewed Original ResearchConceptsPERK1/2 inhibitionHuman osteosarcoma cellsBim expressionSubset of patientsOsteosarcoma cellsConventional cytotoxic agentsConventional cytotoxic treatmentAnti-cancer effectsInhibition of pERK1/2Pro-apoptotic mechanismsMultifocal osteosarcomaMultimodality chemotherapyCytotoxic treatmentUpregulation of BimOsteosarcoma treatmentOsteosarcoma cell deathCytotoxic agentsExpression of BimPotential mediatorsTreatment of PD98059UpregulationTreatmentPD98059 treatmentInhibitionCell death
2007
Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells
Kim DW, Seo SW, Cho SK, Chang SS, Lee HW, Lee E, Block JA, Hei TK, Lee FY. Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells. Journal Of Orthopaedic Research® 2007, 25: 820-828. PMID: 17343283, DOI: 10.1002/jor.20377.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisApoptosis Regulatory ProteinsBcl-X ProteinBone NeoplasmsCell Line, TumorCell SurvivalChondrocytesChondrosarcomaGene Expression Regulation, NeoplasticHumansProto-Oncogene Proteins c-bcl-2Radiation ToleranceRNA, MessengerRNA, Small InterferingX-Linked Inhibitor of Apoptosis ProteinConceptsBcl-xLCell deathChondrosarcoma cellsGene silencingBcl-2Cell survival genesHuman chondrosarcoma cell lineClonogenic survival assaysChondrosarcoma cell linesNovel therapeutic conceptsCorresponding siRNAAntiapoptotic genesApoptotic pathwaySurvival genesAntiapoptotic mRNAsCell survivalXIAP geneMost chondrosarcomasAdjuvant therapySurgical resectionGenesSurvival assaysTherapeutic conceptsCell linesSilencing