2024
Chimeric antigen receptors: “CARs” in the fast lane for rheumatology
Johnson N, Koumpouras F. Chimeric antigen receptors: “CARs” in the fast lane for rheumatology. Current Opinion In Rheumatology 2024, 36: 176-183. PMID: 38517338, PMCID: PMC11224568, DOI: 10.1097/bor.0000000000001012.Peer-Reviewed Original ResearchConceptsChimeric antigen receptorCAR-T treatmentCAR-TB cellsAutoimmune diseasesRheumatologic diseasesReview current clinical dataSevere refractory autoimmune diseasesReconstitution of B cellsRefractory autoimmune diseasesTreatment of rheumatologic diseasesB-cell malignanciesCompassionate use programB cell populationsLaboratory remissionRefractory SLECD19-CARField of autoimmunityRefractory diseaseClinical responseNaive phenotypeSevere lupusMultiple myelomaAutoimmune modelsT cells
2020
IL-7 receptor alpha defines heterogeneity and signature of human effector memory CD8+ T cells in high dimensional analysis
Shin MS, Kim D, Yim K, Park HJ, You S, Dong X, Koumpouras F, Shaw AC, Fan R, Krishnaswamy S, Kang I. IL-7 receptor alpha defines heterogeneity and signature of human effector memory CD8+ T cells in high dimensional analysis. Cellular Immunology 2020, 355: 104155. PMID: 32619811, PMCID: PMC7415611, DOI: 10.1016/j.cellimm.2020.104155.Peer-Reviewed Original ResearchConceptsSingle-cell RNA-seqHuman effector memory CD8Effector memory CD8T cellsIL-7RαMemory CD8Gene regulationTranscription factorsRNA-seqPossible biological significanceDownstream eventsEM CD8Expression patternsExpressional relationshipDifferential expressionCytokine receptorsComprehensive landscapeHigh-dimensional cytometryBiological significanceIL-7 receptor alphaKey moleculesIL-7 receptor alpha chainReceptor alpha chainBiological implicationsHeterogeneous cell subsetsDefining heterogeneity and biological signature in human effector memory CD8+ T cells expressing different levels of IL-7 receptor alpha by high-dimensional analysis
Shin M, Kim D, Park H, Dong X, Koumpouras F, Kang I. Defining heterogeneity and biological signature in human effector memory CD8+ T cells expressing different levels of IL-7 receptor alpha by high-dimensional analysis. The Journal Of Immunology 2020, 204: 154.19-154.19. DOI: 10.4049/jimmunol.204.supp.154.19.Peer-Reviewed Original ResearchHuman effector memory CD8EM CD8Effector memory CD8T cellsIL-7RαMemory CD8Cell subsetsIL-7 receptor alphaIL-7 receptor alpha chainT cell subsetsCo-stimulatory moleculesT cell heterogeneityHigh-dimensional single-cell analysisReceptor alpha chainLupus patientsImmune landscapeCell surface moleculesHeterogeneous cell subsetsT-betCD8Effector functionsDifferential expressionReceptor alphaSingle-cell RNA-seq analysisPathologic conditions