2014
Short-Term Effects of Extended-Release Niacin With and Without the Addition of Laropiprant on Endothelial Function in Individuals With Low HDL-C: A Randomized, Controlled Crossover Trial
Figueiredo V, Vendrame F, Colontoni B, Quinaglia T, Matos-Souza J, Moura F, Coelho O, de Faria E, Sposito A. Short-Term Effects of Extended-Release Niacin With and Without the Addition of Laropiprant on Endothelial Function in Individuals With Low HDL-C: A Randomized, Controlled Crossover Trial. Clinical Therapeutics 2014, 36: 961-966. PMID: 24768191, DOI: 10.1016/j.clinthera.2014.03.012.Peer-Reviewed Original ResearchConceptsEffects of extended-release niacinFlow-mediated dilationExtended-release niacinHDL-C levelsHDL-CEndothelial functionDay 7Reduced plasma concentrations of high-density lipoprotein cholesterolLow HDL-C levelsHDL-C levels <Plasma concentrations of high-density lipoprotein cholesterolHigh-density lipoprotein cholesterolConcentrations of high-density lipoprotein cholesterolLow HDL-C.Low HDL-CHeme oxygenase-1 pathwayTreatment period 1C-reactive proteinPlasma HDL-CTreatment period 2Improving endothelial functionEffects of niacinTransfer protein activityShort-term effectsReduced plasma concentrations
2012
High-density lipoprotein levels are strongly associated with the recovery rate of insulin sensitivity during the acute phase of myocardial infarction: A study by euglycemic hyperinsulinemic clamp
Carvalho L, Martins N, Moura F, Cintra R, Almeida O, Quinaglia e Silva J, Sposito A, Group B. High-density lipoprotein levels are strongly associated with the recovery rate of insulin sensitivity during the acute phase of myocardial infarction: A study by euglycemic hyperinsulinemic clamp. Journal Of Clinical Lipidology 2012, 7: 24-28. PMID: 23351579, DOI: 10.1016/j.jacl.2012.10.003.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAge FactorsAgedBlood Chemical AnalysisFemaleGlucose Clamp TechniqueHospitalizationHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInsulin ResistanceLipoproteins, HDLMagnetic Resonance ImagingMaleMiddle AgedMyocardial InfarctionSeverity of Illness IndexSex FactorsTreatment OutcomeTriglyceridesConceptsAcute phase of MIHigh HDL groupHDL groupHDL-CPhase of MIMyocardial infarctionEuglycemic hyperinsulinemic clampAcute phaseInsulin sensitivityIS indexAssociated with increased morbidityConsecutive nondiabetic patientsHyperinsulinemic clampLevels of HDL-CPlasma levels of HDL-CST-segment elevation MIHigh-density lipoprotein levelsLow HDL groupHigh-density lipoprotein (HDLHDL-C levelsPlasma HDL-CWaist circumferenceRate of ISDecrease of insulin sensitivityLipoprotein (HDL