2016
TCF7L2 polymorphism is associated with low nitric oxide release, endothelial dysfunction and enhanced inflammatory response after myocardial infarction
Cintra R, Moura F, Carvalho L, Daher M, Santos S, Costa A, Figueiredo V, Andrade J, Neves F, Quinaglia e Silva J, Sposito A, Group O. TCF7L2 polymorphism is associated with low nitric oxide release, endothelial dysfunction and enhanced inflammatory response after myocardial infarction. BBA Clinical 2016, 5: 159-165. PMID: 27213136, PMCID: PMC4865630, DOI: 10.1016/j.bbacli.2016.03.010.Peer-Reviewed Original ResearchC-reactive proteinFlow-mediated dilationST-elevation MIInterleukin-2Myocardial infarctionInsulin secretionCapacity of insulin secretionNitric oxideAssociated with lower insulin secretionHigher 30-day mortalityNon-diabetic STEMI patientsNon-diabetic patientsT allele carriersTranscription factor 7-like 2Influence clinical outcomesEnhanced inflammatory responseTCF7L2 gene polymorphismPlasma interleukin-2Short-term mortalityEndogenous insulin secretionNitric oxide releaseLower insulin secretionExogenous insulin administrationNitric oxide changesRs7903146 polymorphism
2015
Glycosylated hemoglobin is associated with decreased endothelial function, high inflammatory response, and adverse clinical outcome in non-diabetic STEMI patients
Moura F, Figueiredo V, Teles B, Barbosa M, Pereira L, Costa A, Carvalho L, Cintra R, Almeida O, Quinaglia e Silva J, Nadruz W, Sposito A, Study B. Glycosylated hemoglobin is associated with decreased endothelial function, high inflammatory response, and adverse clinical outcome in non-diabetic STEMI patients. Atherosclerosis 2015, 243: 124-130. PMID: 26385505, DOI: 10.1016/j.atherosclerosis.2015.09.004.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlood GlucoseBrachial ArteryCoronary AngiographyC-Reactive ProteinDiabetes MellitusDietEndothelium, VascularFemaleFollow-Up StudiesGlycated HemoglobinHumansInflammationMagnetic Resonance ImagingMaleMiddle AgedMyocardial InfarctionNitric OxidePatient AdmissionPercutaneous Coronary InterventionProspective StudiesRisk FactorsROC CurveSensitivity and SpecificityTreatment OutcomeConceptsST-elevation myocardial infarctionFlow-mediated dilationNon-diabetic STEMI patientsC-reactive proteinSTEMI patientsEndothelial functionFollow-upInflammatory responseLong-term risk of MACEIncident diabetesLower HbA1cMedian follow-upClinical follow-upDecreased endothelial functionNon-diabetic patientsRisk of MACEAdverse cardiac eventsAdverse clinical outcomesIncreased inflammatory responseROC curve analysisSudden cardiac deathMeasured plasma glucoseNon-fatal MIPercutaneous coronary interventionLong-term risk
2014
Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity
Virginio V, Nunes V, Moura F, Menezes F, Andreollo N, Rogerio F, Scherrer D, Quintão E, Nakandakare E, Petrucci O, Nadruz-Junior W, de Faria E, Sposito A. Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity. Free Radical Research 2014, 49: 199-203. PMID: 25465091, DOI: 10.3109/10715762.2014.992894.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseSevere peripheral arterial diseaseAtherosclerotic diseasePlasma C-reactive proteinFree of atherosclerotic plaquesSystemic inflammatory activityC-reactive proteinPeripheral atherosclerotic diseaseFree radical-mediated mechanismAtherosclerotic plaquesAdvanced atherosclerotic diseaseArterial tissueArtery diseaseInflammatory activityPlasma concentrationsEnzymatic stressDiseaseArteryRadical-mediated mechanismPlasmaPlaqueOxysterolsTissueLow zinc levels is associated with increased inflammatory activity but not with atherosclerosis, arteriosclerosis or endothelial dysfunction among the very elderly
De Paula RC, Aneni EC, Costa AP, Figueiredo VN, Moura FA, Freitas WM, Quaglia LA, Santos SN, Soares AA, Nadruz W, Blaha M, Blumenthal R, Agatston A, Nasir K, Sposito AC, Group O. Low zinc levels is associated with increased inflammatory activity but not with atherosclerosis, arteriosclerosis or endothelial dysfunction among the very elderly. BBA Clinical 2014, 2: 1-6. PMID: 26676114, PMCID: PMC4633969, DOI: 10.1016/j.bbacli.2014.07.002.Peer-Reviewed Original ResearchFlow-mediated dilationC-reactive proteinDaily intakeEndothelial dysfunctionInflammatory activityCoronary plaquesPlasma levelsPlasma zincCarotid intima-media thicknessZinc levelsArterial wallNoncalcified coronary plaquesAnti-inflammatory treatmentCarotid plaque presenceCRP plasma levelsPlasma CRP levelsSystemic inflammatory activityCoronary calcium scoreIntima-media thicknessCardiac computed tomographyPlasma zinc levelsSignificant differencesLow zinc levelsAverage daily intakeAtherosclerotic burdenShort-Term Effects of Extended-Release Niacin With and Without the Addition of Laropiprant on Endothelial Function in Individuals With Low HDL-C: A Randomized, Controlled Crossover Trial
Figueiredo V, Vendrame F, Colontoni B, Quinaglia T, Matos-Souza J, Moura F, Coelho O, de Faria E, Sposito A. Short-Term Effects of Extended-Release Niacin With and Without the Addition of Laropiprant on Endothelial Function in Individuals With Low HDL-C: A Randomized, Controlled Crossover Trial. Clinical Therapeutics 2014, 36: 961-966. PMID: 24768191, DOI: 10.1016/j.clinthera.2014.03.012.Peer-Reviewed Original ResearchConceptsEffects of extended-release niacinFlow-mediated dilationExtended-release niacinHDL-C levelsHDL-CEndothelial functionDay 7Reduced plasma concentrations of high-density lipoprotein cholesterolLow HDL-C levelsHDL-C levels <Plasma concentrations of high-density lipoprotein cholesterolHigh-density lipoprotein cholesterolConcentrations of high-density lipoprotein cholesterolLow HDL-C.Low HDL-CHeme oxygenase-1 pathwayTreatment period 1C-reactive proteinPlasma HDL-CTreatment period 2Improving endothelial functionEffects of niacinTransfer protein activityShort-term effectsReduced plasma concentrations