2023
Generation of ventralized human thalamic organoids with thalamic reticular nucleus
Kiral F, Cakir B, Tanaka Y, Kim J, Yang W, Wehbe F, Kang Y, Zhong M, Sancer G, Lee S, Xiang Y, Park I. Generation of ventralized human thalamic organoids with thalamic reticular nucleus. Cell Stem Cell 2023, 30: 677-688.e5. PMID: 37019105, PMCID: PMC10329908, DOI: 10.1016/j.stem.2023.03.007.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsSingle-cell RNA sequencingReceptor tyrosine protein kinaseTyrosine protein kinaseEmbryonic stem cellsDisease-associated genesLineage developmentRNA sequencingHuman brain developmentOrganoid systemsStem cellsHuman brain organoidsNeuronal functionBrain organoidsOrganoidsBrain organoid systemsDistinct nucleiBrain developmentThalamic developmentPTCHD1NucleusKinaseGenesSequencing
2021
Brain connectivity inversely scales with developmental temperature in Drosophila
Kiral F, Dutta S, Linneweber G, Hilgert S, Poppa C, Duch C, von Kleist M, Hassan B, Hiesinger P. Brain connectivity inversely scales with developmental temperature in Drosophila. Cell Reports 2021, 37: 110145. PMID: 34936868, DOI: 10.1016/j.celrep.2021.110145.Peer-Reviewed Original ResearchSystematic functional analysis of Rab GTPases reveals limits of neuronal robustness to environmental challenges in flies
Kohrs F, Daumann I, Pavlovic B, Jin E, Kiral F, Lin S, Port F, Wolfenberg H, Mathejczyk T, Linneweber G, Chan C, Boutros M, Hiesinger P. Systematic functional analysis of Rab GTPases reveals limits of neuronal robustness to environmental challenges in flies. ELife 2021, 10: e59594. PMID: 33666175, PMCID: PMC8016483, DOI: 10.7554/elife.59594.Peer-Reviewed Original ResearchConceptsRab GTPasesMembrane traffickingSystematic functional analysisObvious morphological defectsAutophagy-independent roleMutant collectionNull mutantsFertile fliesMaintenance defectsGTPasesNeuronal robustnessFunctional analysisMolecular switchMorphological defectsUnknown functionHalf exhibitMutantsFliesNeuronal functionGenesTraffickingEnvironmental challengesRabRab26Nervous system
2018
Rab GTPases and Membrane Trafficking in Neurodegeneration
Kiral F, Kohrs F, Jin E, Hiesinger P. Rab GTPases and Membrane Trafficking in Neurodegeneration. Current Biology 2018, 28: r471-r486. PMID: 29689231, PMCID: PMC5965285, DOI: 10.1016/j.cub.2018.02.010.Peer-Reviewed Original ResearchConceptsMembrane traffickingRab GTPasesCellular responsesRab GTPase functionGTPase functionMembrane compartmentsGTPasesKey regulatorSecondary consequenceHallmark of neurodegenerationTraffickingSecondary correlateDrivers of pathologyCurrent knowledgeNeurodegenerationHuntington's diseaseMembraneDifferent rolesRegulatorAlzheimer's diseaseCompartmentsDefectsHallmarkDirect consequenceFunction
2017
The where, what, and when of membrane protein degradation in neurons
Jin E, Kiral F, Hiesinger P. The where, what, and when of membrane protein degradation in neurons. Developmental Neurobiology 2017, 78: 283-297. PMID: 28884504, PMCID: PMC5816708, DOI: 10.1002/dneu.22534.Peer-Reviewed Original Research