2024
Dysregulated cerebral blood flow, rather than gray matter Volume, exhibits stronger correlations with blood inflammatory and lipid markers in depression
Kang L, Wang W, Nie Z, Gong Q, Yao L, Xiang D, Zhang N, Tu N, Feng H, Zong X, Bai H, Wang G, Wang F, Bu L, Liu Z. Dysregulated cerebral blood flow, rather than gray matter Volume, exhibits stronger correlations with blood inflammatory and lipid markers in depression. NeuroImage Clinical 2024, 41: 103581. PMID: 38430800, PMCID: PMC10944186, DOI: 10.1016/j.nicl.2024.103581.Peer-Reviewed Original ResearchConceptsGray matter volumeCerebral blood flowMatter volumeArterial spin labelingRight middle temporal gyrusPredictors of MDDMiddle temporal gyrusImmune markersBrain functional changesProportion of MDDExploratory correlation analysisTumor necrosis factor-alphaBlood flowMDD patientsDepressive disorderAngular gyrusTemporal gyrusNecrosis factor-alphaMDDBrain regionsCerebral blood flow changesBlood lipid levelsInferior temporalCase-control comparisonCD4 countState- and trait-related dysfunctions in bipolar disorder across different mood states: a graph theory study
Chen Y, Zhao P, Pan C, Chang M, Zhang X, Duan J, Wei Y, Tang Y, Wang F. State- and trait-related dysfunctions in bipolar disorder across different mood states: a graph theory study. Journal Of Psychiatry And Neuroscience 2024, 49: e11-e22. PMID: 38238036, PMCID: PMC10803102, DOI: 10.1503/jpn.230069.Peer-Reviewed Original ResearchConceptsDepressed BDBipolar disorderEuthymic BDMood statesManic BDDiffusion-tensor imagingHealthy controlsGenetic riskWhite matter networksGlobal efficiencyFrontolimbic circuitsCross-sectional natureStructural topological propertiesGraph theory approachSecondary analysisMedication effectsLocal network changesMoodLocal efficiencyClinical variablesEpisode countsNetwork changesDisordersStructural networkHigh-risk individualsIntegrative omics analysis reveals epigenomic and transcriptomic signatures underlying brain structural deficits in major depressive disorder
Zheng J, Womer F, Tang L, Guo H, Zhang X, Tang Y, Wang F. Integrative omics analysis reveals epigenomic and transcriptomic signatures underlying brain structural deficits in major depressive disorder. Translational Psychiatry 2024, 14: 17. PMID: 38195555, PMCID: PMC10776753, DOI: 10.1038/s41398-023-02724-8.Peer-Reviewed Original ResearchConceptsGray matter volumeBrain structural deficitsFrontal cortexGMV changesStructural deficitsDecreased GMVGray matter volume abnormalitiesInferior frontal cortexAnterior cingulate cortexAllen Human Brain AtlasDifferentially methylated CpG positionsGray matter abnormalitiesHuman Brain AtlasRegionally specific correlationsDepressive disorderCingulate cortexMatter volumeMorphological deficitsMDDBetween-group differencesCortex regionsCortexSynaptic transmission processesDeficitsHealthy controls
2023
Prediction of anxious depression using multimodal neuroimaging and machine learning
Zhou E, Wang W, Ma S, Xie X, Kang L, Xu S, Deng Z, Gong Q, Nie Z, Yao L, Bu L, Wang F, Liu Z. Prediction of anxious depression using multimodal neuroimaging and machine learning. NeuroImage 2023, 285: 120499. PMID: 38097055, DOI: 10.1016/j.neuroimage.2023.120499.Peer-Reviewed Original Research
2009
Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls.
Wang F, Jiang T, Sun Z, Teng SL, Luo X, Zhu Z, Zang Y, Zhang H, Yue W, Qu M, Lu T, Hong N, Huang H, Blumberg HP, Zhang D. Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls. Journal Of Psychiatry And Neuroscience 2009, 34: 181-6. PMID: 19448847, PMCID: PMC2674970.Peer-Reviewed Original ResearchConceptsAnterior cingulumFractional anisotropyHealthy controlsBrain regionsDiagnosis of schizophreniaDiffusion tensorWhite matter connectivityHealthy menWhite matter structuresT carriersMyelin integrityTT subgroupPatientsProminent involvementT alleleReciprocal connectionsAnterior componentC alleleCingulum bundleSchizophrenia groupGenetic susceptibilityCingulum fractional anisotropyNeuregulin1SchizophreniaSmall sample size