2020
Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns
Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Scientific Reports 2020, 10: 3199. PMID: 32081928, PMCID: PMC7035246, DOI: 10.1038/s41598-020-60246-5.Peer-Reviewed Original ResearchConceptsIntensity-modulated proton therapyLow-energy beamsIntensity modulation patternCurrent treatment planProton therapyBiological effectsDelivery strategiesTarget doseTherapeutic indexTreatment planHigh-energy beamsEffective doseEnhanced biological effectClinical potentialTherapyCancer cellsDoseBragg peak
2017
Optimization of Monte Carlo particle transport parameters and validation of a novel high throughput experimental setup to measure the biological effects of particle beams
Patel D, Bronk L, Guan F, Peeler CR, Brons S, Dokic I, Abdollahi A, Rittmüller C, Jäkel O, Grosshans D, Mohan R, Titt U. Optimization of Monte Carlo particle transport parameters and validation of a novel high throughput experimental setup to measure the biological effects of particle beams. Medical Physics 2017, 44: 6061-6073. PMID: 28880368, DOI: 10.1002/mp.12568.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TumorHumansMonte Carlo MethodRadiometryRelative Biological EffectivenessUncertainty
2015
Spatial mapping of the biologic effectiveness of scanned particle beams: towards biologically optimized particle therapy
Guan F, Bronk L, Titt U, Lin SH, Mirkovic D, Kerr MD, Zhu XR, Dinh J, Sobieski M, Stephan C, Peeler CR, Taleei R, Mohan R, Grosshans DR. Spatial mapping of the biologic effectiveness of scanned particle beams: towards biologically optimized particle therapy. Scientific Reports 2015, 5: 9850. PMID: 25984967, PMCID: PMC4650781, DOI: 10.1038/srep09850.Peer-Reviewed Original ResearchChemoradiation therapy using cyclopamine-loaded liquid–lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles
You J, Zhao J, Wen X, Wu C, Huang Q, Guan F, Wu R, Liang D, Li C. Chemoradiation therapy using cyclopamine-loaded liquid–lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles. Journal Of Controlled Release 2015, 202: 40-48. PMID: 25637565, PMCID: PMC4394992, DOI: 10.1016/j.jconrel.2015.01.031.Peer-Reviewed Original ResearchConceptsCombination therapyHigher antitumor cytotoxicityMurine breast cancerMouse xenograft modelCell linesDesirable pharmacokinetic propertiesChemoradiation therapyTumor sizeTumor responseMouse survivalPancreatic cancerAntitumor cytotoxicitySystemic administrationBreast cancerIntravenous injectionPreclinical studiesTumor relapseRadiation therapyXenograft modelIntratumoral injectionAdenocarcinoma modelTumor growthLower clonogenicityCell responsesTherapy