2022
Roadmap: helium ion therapy
Mairani A, Mein S, Blakely E, Debus J, Durante M, Ferrari A, Fuchs H, Georg D, Grosshans DR, Guan F, Haberer T, Harrabi S, Horst F, Inaniwa T, Karger CP, Mohan R, Paganetti H, Parodi K, Sala P, Schuy C, Tessonnier T, Titt U, Weber U. Roadmap: helium ion therapy. Physics In Medicine And Biology 2022, 67: 15tr02. PMID: 35395649, DOI: 10.1088/1361-6560/ac65d3.Peer-Reviewed Original ResearchConceptsHelium ion beamHeavy ion therapyIon beam therapyHelium ionsIon beamIon therapyRelative biological effectivenessHeavy ion beamsLawrence Berkeley National LaboratoryCarbon ion beamsHelium ion therapyDifferent particle speciesBerkeley National LaboratoryClinical proton beamsCarbon ion therapyLinear energy transferHigh relative biological effectivenessSharp lateral penumbraHigh penetration depthLateral scatteringNeon ionsBeam therapyProton beamParticle speciesTerms of physics
2018
Physical parameter optimization scheme for radiobiological studies of charged particle therapy
Geng C, Gates D, Bronk L, Ma D, Guan F. Physical parameter optimization scheme for radiobiological studies of charged particle therapy. Physica Medica 2018, 51: 13-21. PMID: 30278981, PMCID: PMC6173200, DOI: 10.1016/j.ejmp.2018.06.001.Peer-Reviewed Original ResearchConceptsIon beamParticle therapyPhysical quantitiesDose-averaged linear energy transferC-ion beamsLinear energy transferBiological dose optimizationParticle beamsProton beamBragg curveBragg peakWhole target regionBeamCorresponding physical dataEnergy transferProtonsMonte Carlo simulationsAppropriate biophysical modelSpatial distributionSOBPRadiobiological studiesCarlo simulationsDose spreadIonsLETInvestigation of the dose perturbation effect for therapeutic beams with the presence of a 1.5 T transverse magnetic field in magnetic resonance imaging-guided radiotherapy.
Shao W, Tang X, Bai Y, Shu D, Geng C, Gong C, Guan F. Investigation of the dose perturbation effect for therapeutic beams with the presence of a 1.5 T transverse magnetic field in magnetic resonance imaging-guided radiotherapy. Journal Of Cancer Research And Therapeutics 2018, 14: 184-195. PMID: 29516984, DOI: 10.4103/jcrt.jcrt_1349_16.Peer-Reviewed Original ResearchConceptsT transverse magnetic fieldBeam energyCarbon ion beamsTherapeutic beamTransverse magnetic fieldMagnetic fieldDose perturbationsDose perturbation effectsIon beamMagnetic resonance imaging-guided radiotherapyHigher beam energiesUniform magnetic fieldWater-air interfaceAir-tissue interfacePhoton beamsRadiation fieldPerturbation effectsBragg peakProper energyBeamBeam typeDose distributionEnergyProtonsRadiotherapy methods
2017
Optimization of Monte Carlo particle transport parameters and validation of a novel high throughput experimental setup to measure the biological effects of particle beams
Patel D, Bronk L, Guan F, Peeler CR, Brons S, Dokic I, Abdollahi A, Rittmüller C, Jäkel O, Grosshans D, Mohan R, Titt U. Optimization of Monte Carlo particle transport parameters and validation of a novel high throughput experimental setup to measure the biological effects of particle beams. Medical Physics 2017, 44: 6061-6073. PMID: 28880368, DOI: 10.1002/mp.12568.Peer-Reviewed Original Research
2013
SU‐E‐T‐502: In Search of the Optimum Ion for Radiotherapy
Guan F, Titt U, Bangert M, Mohan R. SU‐E‐T‐502: In Search of the Optimum Ion for Radiotherapy. Medical Physics 2013, 40: 320-320. DOI: 10.1118/1.4814931.Peer-Reviewed Original ResearchFragmentation tailC ionsBragg peakGeant4 Monte Carlo toolkitMonte Carlo toolkitC-ion beamsLateral penumbraPeak dose ratioNarrow Bragg peaksMonoenergetic beamsTypes of ionsIon beamEnergy dependenceBroad beamLET distributionsPristine beamWater phantomNuclear fragmentsBeamDose contributionSpatial doseDifferent ionsProtonsSmaller penumbraIonsSU‐E‐T‐535: On the Out‐Of‐Field‐Doses Caused by Secondary Particles From Light Ion Beams in Charged Particle Therapy
Titt U, Guan F, Mirkovic D, Mohan R. SU‐E‐T‐535: On the Out‐Of‐Field‐Doses Caused by Secondary Particles From Light Ion Beams in Charged Particle Therapy. Medical Physics 2013, 40: 328-328. DOI: 10.1118/1.4814965.Peer-Reviewed Original ResearchLight ion beamsIon beamSecondary particlesLateral dose distributionSource particlesTherapeutic ion beamsLateral dose profilesHeavy ionsHelium ionsBeam parametersNuclear reactionsLateral doseDose depositionEnergy depositionHeavy particlesIon therapyParticle speciesBragg peakCharged Particle TherapyDose profilesWater phantomTarget fragmentationParticle therapyModulation widthPrimary particles