2017
Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis
Arnold P, Askland K, Barlassina C, Bellodi L, Bienvenu O, Black D, Bloch M, Brentani H, Burton C, Camarena B, Cappi C, Cath D, Cavallini M, Conti D, Cook E, Coric V, Cullen B, Cusi D, Davis L, Delorme R, Denys D, Derks E, Eapen V, Edlund C, Erdman L, Falkai P, Figee M, Fyer A, Geller D, Goes F, Grabe H, Grados M, Greenberg B, Grünblatt E, Guo W, Hanna G, Hemmings S, Hounie A, Jenicke M, Keenan C, Kennedy J, Khramtsova E, Konkashbaev A, Knowles J, Krasnow J, Lange C, Lanzagorta N, Leboyer M, Lennertz L, Li B, Liang K, Lochner C, Macciardi F, Maher B, Maier W, Marconi M, Mathews C, Matthesien M, McCracken J, McLaughlin N, Miguel E, Moessner R, Murphy D, Neale B, Nestadt G, Nestadt P, Nicolini H, Nurmi E, Osiecki L, Pauls D, Piacentini J, Posthuma D, Pulver A, Qin H, Rasmussen S, Rauch S, Richter M, Riddle M, Ripke S, Ruhrmann S, Sampaio A, Samuels J, Scharf J, Shugart Y, Smit J, Stein D, Stewart S, Turiel M, Vallada H, Veenstra-VanderWeele J, Wagner M, Walitza S, Wang Y, Wendland J, Vulink N, Yu D, Zai G. Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis. Molecular Psychiatry 2017, 23: 1181-1188. PMID: 28761083, PMCID: PMC6660151, DOI: 10.1038/mp.2017.154.Peer-Reviewed Original ResearchMeSH KeywordsAllelesCase-Control StudiesFemaleGene FrequencyGenetic LinkageGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMultifactorial InheritanceNeoplasm ProteinsObsessive-Compulsive DisorderPolymorphism, Single NucleotideReceptors, GlutamateRNA, Long NoncodingWhite PeopleConceptsGenome-wide association studiesSingle-nucleotide polymorphismsIOCDF-GCAssociation studiesOriginal genome-wide association studiesIndividualized genome-wide association studySingle-nucleotide polymorphism heritabilityIndividuals of European ancestryGenome-wide significanceGenome-wide studiesComplex genetic architectureSNP-based heritabilityGenetic association studiesPolygenic risk scoresLinkage peakCase-control statusMeta-analysisTop-ranked signalsHaplotype blocksDistribution of p-valuesPhenotypic varianceAllele frequenciesEuropean ancestryGenetic causeGenetics Collaborative
2015
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study
Sampaio A, Hounie A, Petribú K, Cappi C, Morais I, Vallada H, do Rosário M, Stewart S, Fargeness J, Mathews C, Arnold P, Hanna G, Richter M, Kennedy J, Fontenelle L, de Bragança Pereira C, Pauls D, Miguel E. COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study. PLOS ONE 2015, 10: e0119592. PMID: 25793616, PMCID: PMC4368617, DOI: 10.1371/journal.pone.0119592.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesCatechol O-MethyltransferaseChildEpistasis, GeneticFamilyFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHaplotypesHumansLinkage DisequilibriumMaleMonoamine OxidaseObsessive-Compulsive DisorderPhenotypePolymorphism, Single NucleotideYoung AdultConceptsAssociation studiesBroad spectrum phenotypesTransmission disequilibrium analysisSingle geneSingle nucleotide polymorphismsGenetic association studiesGene-gene interactionsGenesClassical case-control designDisequilibrium analysisGenetic componentAssociation investigationsEpistatic influencesPhenotypePolymorphismSpectrum phenotypeEpistasisOCD susceptibilityAlternative strategyRoleNarrow phenotype
2007
Association analysis between a VNTR intron 8 polymorphism of the dopamine transporter gene (SLC6A3) and obsessive- compulsive disorder in a Brazilian sample
Miguita K, Cordeiro Q, Siqueira-Roberto J, Shavitt R, Castillo J, Castillo A, Miguel E, Vallada H. Association analysis between a VNTR intron 8 polymorphism of the dopamine transporter gene (SLC6A3) and obsessive- compulsive disorder in a Brazilian sample. Arquivos De Neuro-Psiquiatria 2007, 65: 936-941. PMID: 18094849, DOI: 10.1590/s0004-282x2007000600002.Peer-Reviewed Original Research
2006
Association study between the 1287 A/G exonic polymorphism of the norepinephrine transporter (NET) gene and obsessive-compulsive disorder in a Brazilian sample
Miguita K, Cordeiro Q, Shavitt R, Miguel E, Vallada H. Association study between the 1287 A/G exonic polymorphism of the norepinephrine transporter (NET) gene and obsessive-compulsive disorder in a Brazilian sample. Brazilian Journal Of Psychiatry 2006, 28: 158-159. PMID: 16810402, DOI: 10.1590/s1516-44462006000200017.Peer-Reviewed Original Research