2017
Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis
Arnold P, Askland K, Barlassina C, Bellodi L, Bienvenu O, Black D, Bloch M, Brentani H, Burton C, Camarena B, Cappi C, Cath D, Cavallini M, Conti D, Cook E, Coric V, Cullen B, Cusi D, Davis L, Delorme R, Denys D, Derks E, Eapen V, Edlund C, Erdman L, Falkai P, Figee M, Fyer A, Geller D, Goes F, Grabe H, Grados M, Greenberg B, Grünblatt E, Guo W, Hanna G, Hemmings S, Hounie A, Jenicke M, Keenan C, Kennedy J, Khramtsova E, Konkashbaev A, Knowles J, Krasnow J, Lange C, Lanzagorta N, Leboyer M, Lennertz L, Li B, Liang K, Lochner C, Macciardi F, Maher B, Maier W, Marconi M, Mathews C, Matthesien M, McCracken J, McLaughlin N, Miguel E, Moessner R, Murphy D, Neale B, Nestadt G, Nestadt P, Nicolini H, Nurmi E, Osiecki L, Pauls D, Piacentini J, Posthuma D, Pulver A, Qin H, Rasmussen S, Rauch S, Richter M, Riddle M, Ripke S, Ruhrmann S, Sampaio A, Samuels J, Scharf J, Shugart Y, Smit J, Stein D, Stewart S, Turiel M, Vallada H, Veenstra-VanderWeele J, Wagner M, Walitza S, Wang Y, Wendland J, Vulink N, Yu D, Zai G. Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis. Molecular Psychiatry 2017, 23: 1181-1188. PMID: 28761083, PMCID: PMC6660151, DOI: 10.1038/mp.2017.154.Peer-Reviewed Original ResearchMeSH KeywordsAllelesCase-Control StudiesFemaleGene FrequencyGenetic LinkageGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMultifactorial InheritanceNeoplasm ProteinsObsessive-Compulsive DisorderPolymorphism, Single NucleotideReceptors, GlutamateRNA, Long NoncodingWhite PeopleConceptsGenome-wide association studiesSingle-nucleotide polymorphismsIOCDF-GCAssociation studiesOriginal genome-wide association studiesIndividualized genome-wide association studySingle-nucleotide polymorphism heritabilityIndividuals of European ancestryGenome-wide significanceGenome-wide studiesComplex genetic architectureSNP-based heritabilityGenetic association studiesPolygenic risk scoresLinkage peakCase-control statusMeta-analysisTop-ranked signalsHaplotype blocksDistribution of p-valuesPhenotypic varianceAllele frequenciesEuropean ancestryGenetic causeGenetics Collaborative
2012
Genome-wide association study of obsessive-compulsive disorder
Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund C, Rauch S, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe H, Lennertz L, Wagner M, Bellodi L, Cavallini M, Richter M, Cook E, Kennedy J, Rosenberg D, Stein D, Hemmings S, Lochner C, Azzam A, Chavira D, Fournier E, Garrido H, Sheppard B, Umaña P, Murphy D, Wendland J, Veenstra-VanderWeele J, Denys D, Blom R, Deforce D, Van Nieuwerburgh F, Westenberg H, Walitza S, Egberts K, Renner T, Miguel E, Cappi C, Hounie A, Conceição do Rosário M, Sampaio A, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato C, Pato M, Voyiaziakis E, Heutink P, Cath D, Posthuma D, Smit J, Samuels J, Bienvenu O, Cullen B, Fyer A, Grados M, Greenberg B, McCracken J, Riddle M, Wang Y, Coric V, Leckman J, Bloch M, Pittenger C, Eapen V, Black D, Ophoff R, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs J, Cookson M, Singleton A, Hardy J, Crenshaw A, Parkin M, Mirel D, Conti D, Purcell S, Nestadt G, Hanna G, Jenike M, Knowles J, Cox N, Pauls D. Genome-wide association study of obsessive-compulsive disorder. Molecular Psychiatry 2012, 18: 788-798. PMID: 22889921, PMCID: PMC4218751, DOI: 10.1038/mp.2012.85.Peer-Reviewed Original ResearchConceptsExpression quantitative trait lociSingle nucleotide polymorphismsGenome-wide significant levelGenome-wide significance thresholdX-chromosome single nucleotide polymorphismsGenome-wide association studiesTrio-based analysisQuantitative trait lociAncestry-matched controlsComplex genetic etiologyTrait lociCase-control association analysisMethylation QTLsGenetic variationGene expressionAssociation studiesTop signalsAssociation analysisBroader roleSignificant enrichmentSNP microarraysCase-control sampleNucleotide polymorphismsGenetic etiologySignificance threshold