2017
Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis
Arnold P, Askland K, Barlassina C, Bellodi L, Bienvenu O, Black D, Bloch M, Brentani H, Burton C, Camarena B, Cappi C, Cath D, Cavallini M, Conti D, Cook E, Coric V, Cullen B, Cusi D, Davis L, Delorme R, Denys D, Derks E, Eapen V, Edlund C, Erdman L, Falkai P, Figee M, Fyer A, Geller D, Goes F, Grabe H, Grados M, Greenberg B, Grünblatt E, Guo W, Hanna G, Hemmings S, Hounie A, Jenicke M, Keenan C, Kennedy J, Khramtsova E, Konkashbaev A, Knowles J, Krasnow J, Lange C, Lanzagorta N, Leboyer M, Lennertz L, Li B, Liang K, Lochner C, Macciardi F, Maher B, Maier W, Marconi M, Mathews C, Matthesien M, McCracken J, McLaughlin N, Miguel E, Moessner R, Murphy D, Neale B, Nestadt G, Nestadt P, Nicolini H, Nurmi E, Osiecki L, Pauls D, Piacentini J, Posthuma D, Pulver A, Qin H, Rasmussen S, Rauch S, Richter M, Riddle M, Ripke S, Ruhrmann S, Sampaio A, Samuels J, Scharf J, Shugart Y, Smit J, Stein D, Stewart S, Turiel M, Vallada H, Veenstra-VanderWeele J, Wagner M, Walitza S, Wang Y, Wendland J, Vulink N, Yu D, Zai G. Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis. Molecular Psychiatry 2017, 23: 1181-1188. PMID: 28761083, PMCID: PMC6660151, DOI: 10.1038/mp.2017.154.Peer-Reviewed Original ResearchMeSH KeywordsAllelesCase-Control StudiesFemaleGene FrequencyGenetic LinkageGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMultifactorial InheritanceNeoplasm ProteinsObsessive-Compulsive DisorderPolymorphism, Single NucleotideReceptors, GlutamateRNA, Long NoncodingWhite PeopleConceptsGenome-wide association studiesSingle-nucleotide polymorphismsIOCDF-GCAssociation studiesOriginal genome-wide association studiesIndividualized genome-wide association studySingle-nucleotide polymorphism heritabilityIndividuals of European ancestryGenome-wide significanceGenome-wide studiesComplex genetic architectureSNP-based heritabilityGenetic association studiesPolygenic risk scoresLinkage peakCase-control statusMeta-analysisTop-ranked signalsHaplotype blocksDistribution of p-valuesPhenotypic varianceAllele frequenciesEuropean ancestryGenetic causeGenetics Collaborative
2014
Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette’s Syndrome and OCD
Yu D, Mathews CA, Scharf JM, Neale BM, Davis LK, Gamazon ER, Derks EM, Evans P, Edlund CK, Crane J, Fagerness JA, Osiecki L, Gallagher P, Gerber G, Haddad S, Illmann C, McGrath LM, Mayerfeld C, Arepalli S, Barlassina C, Barr CL, Bellodi L, Benarroch F, Berrió GB, Bienvenu OJ, Black DW, Bloch MH, Brentani H, Bruun RD, Budman CL, Camarena B, Campbell DD, Cappi C, Silgado JC, Cavallini MC, Chavira DA, Chouinard S, Cook EH, Cookson MR, Coric V, Cullen B, Cusi D, Delorme R, Denys D, Dion Y, Eapen V, Egberts K, Falkai P, Fernandez T, Fournier E, Garrido H, Geller D, Gilbert DL, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Hardy J, Heiman GA, Hemmings SM, Herrera LD, Hezel DM, Hoekstra PJ, Jankovic J, Kennedy JL, King RA, Konkashbaev AI, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Lupoli S, Macciardi F, Maier W, Manunta P, Marconi M, McCracken JT, Mesa Restrepo SC, Moessner R, Moorjani P, Morgan J, Muller H, Murphy DL, Naarden AL, Nurmi E, Ochoa WC, Ophoff RA, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner T, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosário MC, Rosenberg D, Ruhrmann S, Sabatti C, Salvi E, Sampaio AS, Samuels J, Sandor P, Service SK, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Turiel M, Valencia Duarte AV, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Weale M, Weiss R, Wendland JR, Westenberg HG, Shugart YY, Hounie AG, Miguel EC, Nicolini H, Wagner M, Ruiz-Linares A, Cath DC, McMahon W, Posthuma D, Oostra BA, Nestadt G, Rouleau GA, Purcell S, Jenike MA, Heutink P, Hanna GL, Conti DV, Arnold PD, Freimer NB, Stewart SE, Knowles JA, Cox NJ, Pauls DL. Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette’s Syndrome and OCD. American Journal Of Psychiatry 2014, 172: 82-93. PMID: 25158072, PMCID: PMC4282594, DOI: 10.1176/appi.ajp.2014.13101306.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSingle nucleotide polymorphismsPolygenic score analysisGene expression levelsGenetic architecturePhenotypic varianceCombined genome-wide association studyFunctional variantsPolygenic componentPolygenic signalSignificant polygenic componentExpression levelsGWAS summary statisticsAncestry-matched controlsBrain gene expression levelsComplex genetic relationshipsHeritable neurodevelopmental disorderTrue functional variantsParent-child triosGWAS signalsIndividual single nucleotide polymorphismsWide analysisGenetic variationUnderlying genetic susceptibilityAssociation studies