2017
One‐Hour Postoperative Parathyroid Hormone Levels Do Not Reliably Predict Hypocalcemia After Thyroidectomy
Sahli Z, Najafian A, Kahan S, Schneider E, Zeiger M, Mathur A. One‐Hour Postoperative Parathyroid Hormone Levels Do Not Reliably Predict Hypocalcemia After Thyroidectomy. World Journal Of Surgery 2017, 42: 2128-2133. PMID: 29290070, PMCID: PMC5991999, DOI: 10.1007/s00268-017-4444-2.Peer-Reviewed Original ResearchConceptsPostoperative parathyroid hormone levelsPg/mLParathyroid hormone levelsPostoperative PTHPTH levelsBiochemical hypocalcemiaTotal thyroidectomyCalcium supplementationProspective studyHormone levelsAppropriate calcium supplementationDefinitive study designPostoperative biochemical hypocalcemiaAdditional prospective studiesNormal PTH levelsPTH decreaseCompletion thyroidectomyConsecutive patientsSerum calciumLow PTHPTH 1HypocalcemiaIRB approvalThyroidectomyPTH
2016
Validation of international trauma scoring systems in urban trauma centres in India
Roy N, Gerdin M, Schneider E, Veetil D, Khajanchi M, Kumar V, Saha M, Dharap S, Gupta A, Tomson G, von Schreeb J. Validation of international trauma scoring systems in urban trauma centres in India. Injury 2016, 47: 2459-2464. PMID: 27667119, DOI: 10.1016/j.injury.2016.09.027.Peer-Reviewed Original ResearchConceptsInjury Severity ScoreTrauma Injury Severity ScoreKampala Trauma ScoreTrauma patientsCasualty departmentPhysiological scoreTrauma centerSeverity scoreProspective multi-centre observational cohort studyMulti-center observational cohort studyInjury Severity Scale scoreAdult trauma patientsObservational cohort studySeverity Scale scoreUrban trauma centerHistory of injuryIncome country settingsMiddle-income country settingsHospital mortalityLate mortalityUrban Indian settingAdult patientsCohort studyInpatient mortalityPhysiologic scoreEvaluation of the Effect of Diagnostic Molecular Testing on the Surgical Decision-Making Process for Patients With Thyroid Nodules
Noureldine S, Najafian A, Han P, Olson M, Genther D, Schneider E, Prescott J, Agrawal N, Mathur A, Zeiger M, Tufano R. Evaluation of the Effect of Diagnostic Molecular Testing on the Surgical Decision-Making Process for Patients With Thyroid Nodules. JAMA Otolaryngology - Head & Neck Surgery 2016, 142: 676-82. PMID: 27196108, DOI: 10.1001/jamaoto.2016.0850.Peer-Reviewed Original ResearchConceptsSurgical decision-making processMolecular testingSurgical consultationThyroid nodulesDiagnostic molecular testingEvidence of overtreatmentPertinent treatment optionsSurgical management algorithmRisk of malignancySurgical decision makingSurgical management planRadiological resultsStudy cohortSurgical managementTreatment algorithmProspective studyMean ageTreatment optionsMAIN OUTCOMEPatientsBethesda SystemHistopathology diagnosisControl groupCytopathology classificationHistopathology analysisAssociation of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers
Han PA, Kim HS, Cho S, Fazeli R, Najafian A, Khawaja H, McAlexander M, Dy B, Sorensen M, Aronova A, Sebo TJ, Giordano TJ, Fahey TJ, Thompson GB, Gauger PG, Somervell H, Bishop JA, Eshleman JR, Schneider EB, Witwer KW, Umbricht CB, Zeiger MA. Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers. Thyroid 2016, 26: 532-542. PMID: 26950846, PMCID: PMC4827320, DOI: 10.1089/thy.2015.0378.Peer-Reviewed Original ResearchConceptsCentral lymph node metastasisCentral lymph node dissectionMultivariable logistic regression analysisPapillary thyroid cancerProphylactic central lymph node dissectionLogistic regression analysisLymph node dissectionAggressive clinicopathologic featuresLymph node metastasisEndocrine surgery centersStand-alone markerClinicopathologic featuresMiR-146bNode dissectionIndependent predictorsNode metastasisMiR-222Surgery centersThyroid cancerProphylactic lymph node dissectionRegression analysisIndividual prognostic markersOnly preoperative variablesNode-negative casesMicroRNA expression30‐Day In‐hospital Trauma Mortality in Four Urban University Hospitals Using an Indian Trauma Registry
Roy N, Gerdin M, Ghosh S, Gupta A, Kumar V, Khajanchi M, Schneider E, Gruen R, Tomson G, von Schreeb J. 30‐Day In‐hospital Trauma Mortality in Four Urban University Hospitals Using an Indian Trauma Registry. World Journal Of Surgery 2016, 40: 1299-1307. PMID: 26911610, DOI: 10.1007/s00268-016-3452-y.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBlood PressureChildChild, PreschoolDeveloping CountriesFemaleGlasgow Coma ScaleHospital MortalityHospitalizationHospitals, PublicHospitals, UniversityHospitals, UrbanHumansIndiaInfantMaleMiddle AgedProspective StudiesRegistriesTime-to-TreatmentWounds and InjuriesYoung AdultConceptsHospital trauma mortalityTrauma mortalityUniversity HospitalTrauma systemMortality rateAdmission systolic blood pressureHospital mortality rateDays of hospitalizationGlasgow Coma ScoreSystolic blood pressureUrban university hospitalTrauma mortality ratesPublic university hospitalPhysiological scoringCare delaysLate mortalityComa ScoreBlood pressureMedian ageTrauma patientsTrauma registryAdmission vitalsTrauma careTraumatic injuryHigh-income countriesHaptoglobin 2-2 Genotype Is Associated With Cerebral Salt Wasting Syndrome in Aneurysmal Subarachnoid Hemorrhage
Murthy S, Caplan J, Levy A, Pradilla G, Moradiya Y, Schneider E, Shalom H, Ziai W, Tamargo R, Nyquist P. Haptoglobin 2-2 Genotype Is Associated With Cerebral Salt Wasting Syndrome in Aneurysmal Subarachnoid Hemorrhage. Neurosurgery 2016, 78: 71-76. PMID: 26348010, DOI: 10.1227/neu.0000000000001000.Peer-Reviewed Original ResearchConceptsAneurysmal subarachnoid hemorrhageCerebral infarctionSubarachnoid hemorrhageHp genotypeHp 2Cerebral Salt Wasting SyndromeGlasgow Outcome ScoreCerebral saltUrine sodiumBaseline characteristicsSymptomatic vasospasmIndependent predictorsUrine outputClinical outcomesOutcome scoresSubsequent vasospasmFunctional outcomeProspective confirmationMultivariate regression modelGenotype testingHaptoglobin 2Haptoglobin genotypeOutcome measuresHemorrhagePatients
2015
Socioeconomic correlates of trauma: An analysis of emergency ward patients in Yaoundé, Cameroon
Kacker S, Bishai D, Mballa G, Monono M, Schneider E, Ngamby K, Hyder A, Juillard C. Socioeconomic correlates of trauma: An analysis of emergency ward patients in Yaoundé, Cameroon. Injury 2015, 47: 658-664. PMID: 26763297, DOI: 10.1016/j.injury.2015.12.011.Peer-Reviewed Original ResearchConceptsLowest SES quintileSocioeconomic statusTrauma centerTreatment outcomesInjury severitySevere injuriesSES quintilesWealth scoreEmergency ward patientsLargest trauma hospitalMajor trauma centreCare-seeking behaviorFuture trauma researchSeverity of injuryRoad traffic injuriesHigher socioeconomic statusEffect of SESProspective registryTrauma patientsWard patientsCentral HospitalInjury characteristicsTrauma hospitalEmergency wardTrauma outcomesIntraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Study
Zysk AM, Chen K, Gabrielson E, Tafra L, May Gonzalez EA, Canner JK, Schneider EB, Cittadine AJ, Scott Carney P, Boppart SA, Tsuchiya K, Sawyer K, Jacobs LK. Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Study. Annals Of Surgical Oncology 2015, 22: 3356-3362. PMID: 26202553, PMCID: PMC4839389, DOI: 10.1245/s10434-015-4665-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularFeasibility StudiesFemaleFollow-Up StudiesHumansIntraoperative PeriodMastectomy, SegmentalMicrosurgeryMiddle AgedNeoplasm InvasivenessNeoplasm StagingPrognosisProspective StudiesReoperationTomography, Optical CoherenceConceptsBreast-conserving surgeryPositive marginsFinal marginsIntraoperative assessmentEarly-stage breast cancerMajority of reoperationsBreast conserving surgeryFinal surgical marginsMethodsForty-six patientsCavity shave marginsJohns Hopkins HospitalReoperation rateMargin statusSitu diseaseSurgical marginsMulticenter studyPostoperative histopathologyNegative marginsResultsA totalPatient outcomesSpecimen marginsBreast cancerMedical CenterMargin specimensBlinded studyA modified Kampala trauma score (KTS) effectively predicts mortality in trauma patients
Weeks S, Stevens K, Haider A, Efron D, Haut E, MacKenzie E, Schneider E. A modified Kampala trauma score (KTS) effectively predicts mortality in trauma patients. Injury 2015, 47: 125-129. PMID: 26256783, DOI: 10.1016/j.injury.2015.07.004.Peer-Reviewed Original ResearchConceptsNew Injury Severity ScoreInjury Severity ScoreKampala Trauma ScoreTrauma patientsSeverity scoreTrauma ScorePhysiologic measuresMortality predictionNon-trauma center hospitalsSeverity scoring toolsPre-hospital intubationCenter HospitalInjury scoreAnatomical injuryMortality riskLevel IInjury severityRespiratory ratePhysiologic dataScoring toolOutcome predictionMortalitySignificant predictorsCharacteristic curveSimilar predictive abilityInvestigating the relationship between weather and violence in Baltimore, Maryland, USA
Michel S, Wang H, Selvarajah S, Canner J, Murrill M, Chi A, Efron D, Schneider E. Investigating the relationship between weather and violence in Baltimore, Maryland, USA. Injury 2015, 47: 272-276. PMID: 26233631, DOI: 10.1016/j.injury.2015.07.006.Peer-Reviewed Original ResearchUnconscious Race and Class Biases among Registered Nurses: Vignette-Based Study Using Implicit Association Testing
Haider AH, Schneider EB, Sriram N, Scott VK, Swoboda SM, Zogg CK, Dhiman N, Haut ER, Efron DT, Pronovost PJ, Freischlag JA, Lipsett PA, Cornwell EE, MacKenzie EJ, Cooper LA. Unconscious Race and Class Biases among Registered Nurses: Vignette-Based Study Using Implicit Association Testing. Journal Of The American College Of Surgeons 2015, 220: 1077-1086.e3. PMID: 25998083, DOI: 10.1016/j.jamcollsurg.2015.01.065.Peer-Reviewed Original Research
2014
Presence of Haptoglobin-2 Allele Is Associated with Worse Functional Outcomes After Spontaneous Intracerebral Hemorrhage
Murthy SB, Levy AP, Duckworth J, Schneider EB, Shalom H, Hanley DF, Tamargo RJ, Nyquist PA. Presence of Haptoglobin-2 Allele Is Associated with Worse Functional Outcomes After Spontaneous Intracerebral Hemorrhage. World Neurosurgery 2014, 83: 583-587. PMID: 25527876, DOI: 10.1016/j.wneu.2014.12.013.Peer-Reviewed Original Research
2013
A protocol-driven approach to early extubation after heart surgery
Fitch Z, Debesa O, Ohkuma R, Duquaine D, Steppan J, Schneider E, Whitman G. A protocol-driven approach to early extubation after heart surgery. Journal Of Thoracic And Cardiovascular Surgery 2013, 147: 1344-1350. PMID: 24269120, DOI: 10.1016/j.jtcvs.2013.10.032.Peer-Reviewed Original ResearchConceptsPatient shiveringRisk factorsVentilation timePostoperative mechanical ventilation timeLow body temperatureStandardized protocolMechanical ventilation timeRate of reintubationIndependent risk factorPercent of patientsPeriod 1 patientProtocol-driven approachBody temperatureReintubation rateEarly extubationProlonged ventilationCoronary bypassHeart surgeryReminder sheetsMultidisciplinary committeePatientsLogistic regressionPatient safetyExtubationBaseline practiceDoes BRAF V600E Mutation Predict Aggressive Features in Papillary Thyroid Cancer? Results From Four Endocrine Surgery Centers
Li C, Han P, Lee K, Lee L, Fox A, Beninato T, Thiess M, Dy B, Sebo T, Thompson G, Grant C, Giordano T, Gauger P, Doherty G, Fahey T, Bishop J, Eshleman J, Umbricht C, Schneider E, Zeiger M. Does BRAF V600E Mutation Predict Aggressive Features in Papillary Thyroid Cancer? Results From Four Endocrine Surgery Centers. The Journal Of Clinical Endocrinology & Metabolism 2013, 98: 3702-3712. PMID: 23969188, DOI: 10.1210/jc.2013-1584.Peer-Reviewed Original ResearchConceptsCentral lymph node metastasisCentral lymph node dissectionPapillary thyroid cancerClassical variant papillary thyroid cancerRoutine central lymph node dissectionEndocrine surgery centersBRAF mutationsIndependent predictorsMultivariable analysisAggressive featuresBRAF statusSurgery centersThyroid cancerProphylactic central lymph node dissectionBivariate analysisPresence of LNMLymph node dissectionAggressive clinicopathologic featuresTumor-related factorsAmerican Joint CommitteeLymph node metastasisTreatment of patientsBRAF mutation statusBRAF V600E mutationCentral LNM