2018
Prognostic Impact of Serum Pancreastatin Following Chemoembolization for Neuroendocrine Tumors
Strosberg D, Schneider EB, Onesti J, Saunders N, Konda B, Shah M, Dillhoff M, Schmidt CR, Shirley LA. Prognostic Impact of Serum Pancreastatin Following Chemoembolization for Neuroendocrine Tumors. Annals Of Surgical Oncology 2018, 25: 3613-3620. PMID: 30182331, DOI: 10.1245/s10434-018-6741-x.Peer-Reviewed Original ResearchConceptsRepeat transarterial chemoembolizationMetastatic neuroendocrine tumorsTransarterial chemoembolizationPancreastatin levelsNeuroendocrine tumorsOverall survivalPrognostic impactImproved overall survivalProgressive liver diseaseFirst transarterial chemoembolizationWorse overall survivalUseful prognostic indicatorLong-term survivalPg/mLConclusionsFor patientsPost TACECarcinoid syndromeTACE treatmentLiver metastasesPatient demographicsImproved survivalLiver diseasePoor outcomePrognostic indicatorResultsA totalNeutrophil lymphocyte ratio and transarterial chemoembolization in neuroendocrine tumor metastases
McDermott SM, Saunders ND, Schneider EB, Strosberg D, Onesti J, Dillhoff M, Schmidt CR, Shirley LA. Neutrophil lymphocyte ratio and transarterial chemoembolization in neuroendocrine tumor metastases. Journal Of Surgical Research 2018, 232: 369-375. PMID: 30463743, DOI: 10.1016/j.jss.2018.06.058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChemoembolization, TherapeuticFemaleFollow-Up StudiesHumansKaplan-Meier EstimateLeukocyte CountLiver NeoplasmsLymphocytesMaleMiddle AgedNeuroendocrine TumorsNeutrophilsPreoperative PeriodPrognosisResponse Evaluation Criteria in Solid TumorsRetrospective StudiesYoung AdultConceptsMedian overall survivalMetastatic neuroendocrine tumorsTransarterial chemoembolizationOverall survivalNeuroendocrine tumorsSingle tertiary medical centerCancer-related treatmentTertiary medical centerNeuroendocrine tumor metastasesPotential treatment strategyElevated NLRLiver metastasesNLR valuesIndependent predictorsBlood workLymphocyte ratioEntire cohortTreatment strategiesPostprocedural careMedical CenterPatientsMultivariate analysisNLRTumor metastasisChemoembolization
2017
Thyroid Nodule Diagnostic Markers in the Face of the New NIFTP Category: Time for a Reset?
Sahli Z, Umbricht C, Schneider E, Zeiger M. Thyroid Nodule Diagnostic Markers in the Face of the New NIFTP Category: Time for a Reset? Thyroid 2017, 27: 1393-1399. PMID: 28859553, DOI: 10.1089/thy.2017.0238.Peer-Reviewed Original ResearchConceptsCancer prevalenceSuspicious fine-needle aspiration (FNA) cytologyNon-invasive follicular thyroid neoplasmFine needle aspiration cytologyThyroid cancer prevalencePapillary-like nuclear featuresFollicular thyroid neoplasmPrecancerous lesionsDifferential diagnosisAspiration cytologyLatter diagnosisClinical validityThyroid neoplasmsOriginal validation studyMolecular panelDiagnostic markerMolecular testsNuclear featuresNIFTP reclassificationPrevalence
2016
Race-based differences in duration of stay among universally insured coronary artery bypass graft patients in military versus civilian hospitals
Chowdhury R, Davis WA, Chaudhary MA, Jiang W, Zogg CK, Schoenfeld AJ, Jaklitsch MT, Kaneko T, Learn PA, Haider AH, Schneider EB. Race-based differences in duration of stay among universally insured coronary artery bypass graft patients in military versus civilian hospitals. Surgery 2016, 161: 1090-1099. PMID: 27932028, DOI: 10.1016/j.surg.2016.10.022.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlack or African AmericanCohort StudiesConfidence IntervalsCoronary Artery BypassCoronary Artery DiseaseDatabases, FactualFemaleHealthcare DisparitiesHospital MortalityHospitals, MilitaryHospitals, PublicHumansLength of StayMaleMiddle AgedPrognosisRegression AnalysisRisk AssessmentSurvival AnalysisTreatment OutcomeUnited StatesUniversal Health InsuranceWhite PeopleConceptsCoronary artery bypass graftArtery bypass graftCoronary artery bypass graft patientsDuration of stayBypass graft patientsBypass graftRace-based differencesGraft patientsBlack patientsMilitary HospitalCivilian hospitalsHospital-level factorsEligible patientsWhite patientsMale patientsCivilian facilitiesWhite racePatientsStayTRICARE coverageNegative binomial regressionHospitalApparent mitigationGraftGreater durationConscious status predicts mortality among patients with isolated traumatic brain injury in administrative data
Alsulaim H, Smart B, Asemota A, Haring R, Canner J, Efron D, Haut E, Schneider E. Conscious status predicts mortality among patients with isolated traumatic brain injury in administrative data. The American Journal Of Surgery 2016, 214: 207-210. PMID: 27663651, DOI: 10.1016/j.amjsurg.2016.07.012.Peer-Reviewed Original ResearchConceptsSevere TBIInjury severityMortality predictionNationwide Emergency Department SampleAdministrative dataEmergency Department SampleTraumatic brain injuryPrevention guidelinesInjury typeBrain injuryUnivariate analysisBrief lossInternational ClassificationOutcome studiesPhysiologic factorsPatientsConscious statusDisease controlLogistic regressionMortalityTBIAdministrative datasetsAnatomical measuresSimilar differencesMeeting CentersAssociation of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers
Han PA, Kim HS, Cho S, Fazeli R, Najafian A, Khawaja H, McAlexander M, Dy B, Sorensen M, Aronova A, Sebo TJ, Giordano TJ, Fahey TJ, Thompson GB, Gauger PG, Somervell H, Bishop JA, Eshleman JR, Schneider EB, Witwer KW, Umbricht CB, Zeiger MA. Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers. Thyroid 2016, 26: 532-542. PMID: 26950846, PMCID: PMC4827320, DOI: 10.1089/thy.2015.0378.Peer-Reviewed Original ResearchConceptsCentral lymph node metastasisCentral lymph node dissectionMultivariable logistic regression analysisPapillary thyroid cancerProphylactic central lymph node dissectionLogistic regression analysisLymph node dissectionAggressive clinicopathologic featuresLymph node metastasisEndocrine surgery centersStand-alone markerClinicopathologic featuresMiR-146bNode dissectionIndependent predictorsNode metastasisMiR-222Surgery centersThyroid cancerProphylactic lymph node dissectionRegression analysisIndividual prognostic markersOnly preoperative variablesNode-negative casesMicroRNA expression
2015
Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Study
Zysk AM, Chen K, Gabrielson E, Tafra L, May Gonzalez EA, Canner JK, Schneider EB, Cittadine AJ, Scott Carney P, Boppart SA, Tsuchiya K, Sawyer K, Jacobs LK. Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Study. Annals Of Surgical Oncology 2015, 22: 3356-3362. PMID: 26202553, PMCID: PMC4839389, DOI: 10.1245/s10434-015-4665-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularFeasibility StudiesFemaleFollow-Up StudiesHumansIntraoperative PeriodMastectomy, SegmentalMicrosurgeryMiddle AgedNeoplasm InvasivenessNeoplasm StagingPrognosisProspective StudiesReoperationTomography, Optical CoherenceConceptsBreast-conserving surgeryPositive marginsFinal marginsIntraoperative assessmentEarly-stage breast cancerMajority of reoperationsBreast conserving surgeryFinal surgical marginsMethodsForty-six patientsCavity shave marginsJohns Hopkins HospitalReoperation rateMargin statusSitu diseaseSurgical marginsMulticenter studyPostoperative histopathologyNegative marginsResultsA totalPatient outcomesSpecimen marginsBreast cancerMedical CenterMargin specimensBlinded studyTrends in Incident Hemodialysis Access and Mortality
Malas MB, Canner JK, Hicks CW, Arhuidese IJ, Zarkowsky DS, Qazi U, Schneider EB, Black JH, Segev DL, Freischlag JA. Trends in Incident Hemodialysis Access and Mortality. JAMA Surgery 2015, 150: 441-448. PMID: 25738981, DOI: 10.1001/jamasurg.2014.3484.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseHemodialysis cathetersArteriovenous fistulaArteriovenous graftsLower mortalityRenal diseaseVascular accessHD outcomesNational Kidney Foundation Kidney Disease Outcomes Quality InitiativeKidney Foundation Kidney Disease Outcomes Quality InitiativeMultivariable Cox proportional hazards modelsPrior renal replacement therapyUS Renal Data SystemCox proportional hazards modelArteriovenous fistula useIncident HD patientsInitiation of hemodialysisRetrospective cohort studyRenal replacement therapyProportional hazards modelFistula useCohort studySurvival benefitHD patientsPropensity score-matching techniqueClinical Presentation of Patients with a Thyroid Follicular Neoplasm: Are there Preoperative Predictors of Malignancy?
Najafian A, Olson M, Schneider E, Zeiger M. Clinical Presentation of Patients with a Thyroid Follicular Neoplasm: Are there Preoperative Predictors of Malignancy? Annals Of Surgical Oncology 2015, 22: 3007-3013. PMID: 25564170, DOI: 10.1245/s10434-014-4324-z.Peer-Reviewed Original ResearchConceptsMalignant follicular neoplasmsFollicular thyroid neoplasmFollicular neoplasmThyroid neoplasmsMalignant follicular thyroid neoplasmsFinal pathologic resultsPresentation of patientsHistory of headMultivariate logistic regressionOdds of malignancyPredictors of malignancyThyroid follicular neoplasmsFollicular thyroid lesionsConcomitant hyperthyroidismMethodsConsecutive patientsNeck radiationPreoperative predictorsClinical predictorsClinical featuresClinical presentationMale sexTertiary hospitalResultsA totalPhysical examinationPathologic results
2014
Variation in Readmission by Hospital After Colorectal Cancer Surgery
Lucas D, Ejaz A, Bischof D, Schneider E, Pawlik T. Variation in Readmission by Hospital After Colorectal Cancer Surgery. JAMA Surgery 2014, 149: 1272-1277. PMID: 25337956, DOI: 10.1001/jamasurg.2014.988.Peer-Reviewed Original ResearchConceptsReadmission ratesColorectal surgeryAppropriate risk adjustmentHierarchical multivariable logistic regression analysisMultivariable logistic regression analysisRisk-adjusted readmission ratesRisk adjustmentRepresentative cancer registryColorectal cancer surgeryEnd Results-MedicareHospital readmission ratesHospital quality metricsRisk-adjusted variationLogistic regression analysisColorectal resectionStudy patientsHospital readmissionMedian agePatient characteristicsCancer surgeryCancer RegistryMAIN OUTCOMEReadmissionUS hospitalsHospitalNo Association Between Hospital-Reported Perioperative Venous Thromboembolism Prophylaxis and Outcome Rates in Publicly Reported Data
JohnBull E, Lau B, Schneider E, Streiff M, Haut E. No Association Between Hospital-Reported Perioperative Venous Thromboembolism Prophylaxis and Outcome Rates in Publicly Reported Data. JAMA Surgery 2014, 149: 400-401. PMID: 24500768, DOI: 10.1001/jamasurg.2013.4935.Peer-Reviewed Original Research
2013
Venous Thromboembolism After Trauma: When Do Children Become Adults?
Van Arendonk K, Schneider E, Haider A, Colombani P, Stewart F, Haut E. Venous Thromboembolism After Trauma: When Do Children Become Adults? JAMA Surgery 2013, 148: 1123-1130. PMID: 24173244, DOI: 10.1001/jamasurg.2013.3558.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsChildChild, PreschoolCohort StudiesConfidence IntervalsDatabases, FactualFemaleHospitalizationHumansIncidenceInfantMaleOdds RatioPrognosisRetrospective StudiesRisk AssessmentTrauma CentersTrauma Severity IndicesTreatment OutcomeUnited StatesVenous ThromboembolismWounds and InjuriesYoung AdultConceptsRisk of VTEVenous thromboembolismPediatric traumaTrauma centerStandardized guidelinesNational Trauma Data BankMultivariable logistic regression modelDiagnosis of VTENational standardized guidelinesOdds of VTEPatients 16 yearsPatients 21 yearsVenous thromboembolism prophylaxisVTE risk factorsPatients 12 yearsTrauma Data BankUS trauma centersAge 16 yearsCentral line placementAge 13 yearsLogistic regression modelsThromboembolism prophylaxisVTE prophylaxisPatient ageYounger patientsDoes BRAF V600E Mutation Predict Aggressive Features in Papillary Thyroid Cancer? Results From Four Endocrine Surgery Centers
Li C, Han P, Lee K, Lee L, Fox A, Beninato T, Thiess M, Dy B, Sebo T, Thompson G, Grant C, Giordano T, Gauger P, Doherty G, Fahey T, Bishop J, Eshleman J, Umbricht C, Schneider E, Zeiger M. Does BRAF V600E Mutation Predict Aggressive Features in Papillary Thyroid Cancer? Results From Four Endocrine Surgery Centers. The Journal Of Clinical Endocrinology & Metabolism 2013, 98: 3702-3712. PMID: 23969188, DOI: 10.1210/jc.2013-1584.Peer-Reviewed Original ResearchConceptsCentral lymph node metastasisCentral lymph node dissectionPapillary thyroid cancerClassical variant papillary thyroid cancerRoutine central lymph node dissectionEndocrine surgery centersBRAF mutationsIndependent predictorsMultivariable analysisAggressive featuresBRAF statusSurgery centersThyroid cancerProphylactic central lymph node dissectionBivariate analysisPresence of LNMLymph node dissectionAggressive clinicopathologic featuresTumor-related factorsAmerican Joint CommitteeLymph node metastasisTreatment of patientsBRAF mutation statusBRAF V600E mutationCentral LNM
2012
Epidemiology of moderate-to-severe penetrating versus closed traumatic brain injury in the Iraq and Afghanistan wars
Orman J, Geyer D, Jones J, Schneider E, Grafman J, Pugh M, DuBose J. Epidemiology of moderate-to-severe penetrating versus closed traumatic brain injury in the Iraq and Afghanistan wars. Journal Of Trauma And Acute Care Surgery 2012, 73: s496-s502. PMID: 23192076, DOI: 10.1097/ta.0b013e318275473c.Peer-Reviewed Original ResearchMeSH KeywordsAdultAfghan Campaign 2001-Age DistributionBrain InjuriesChi-Square DistributionFemaleHumansIncidenceInjury Severity ScoreIraq War, 2003-2011MaleMass Casualty IncidentsMiddle AgedPrognosisRegistriesRetrospective StudiesSex DistributionStatistics, NonparametricSurvival AnalysisUnited StatesWarfareWounds, NonpenetratingWounds, PenetratingYoung AdultConceptsClosed traumatic brain injuryTraumatic brain injuryBrain injuryInjury severityAbbreviated Injury Scale scoreSevere closed traumatic brain injuryCombat-related traumatic brain injuryJoint Theater Trauma RegistryInjury Scale scoreOverall injury severitySevere penetratingPatients meeting criteriaSevere brain injuryAnatomic injury severityTrauma registry dataMaximum Abbreviated Injury Scale scoreTrauma registrySurgical interventionSurveillance definitionsRegistry dataTBI severityEpidemiologic studiesNeck woundsMeeting criteriaScale score
2011
Predictive factors of malignancy in pediatric thyroid nodules
Roy R, Kouniavsky G, Schneider E, Allendorf JD, Chabot JA, Logerfo P, Dackiw AP, Colombani P, Zeiger MA, Lee JA. Predictive factors of malignancy in pediatric thyroid nodules. Surgery 2011, 150: 1228-1233. PMID: 22136845, DOI: 10.1016/j.surg.2011.09.023.Peer-Reviewed Original ResearchConceptsFine-needle aspiration biopsy specimensPediatric thyroid nodulesPositive predictive valuePalpable lymphadenopathyThyroid nodulesThyroid cancerFamily historyPredictive valueAspiration biopsy specimensPediatric thyroidectomyFinal pathologyClinical factorsClinicopathologic factorsRetrospective reviewTertiary hospitalPredictive factorsHypoechoic lesionsBiopsy specimensHypoechoic nodulesIndeterminate lesionsMalignancyFNAB resultsLymphadenopathyGreater riskCancer