Bcl6 expression specifies the T follicular helper cell program in vivo
Liu X, Yan X, Zhong B, Nurieva RI, Wang A, Wang X, Martin-Orozco N, Wang Y, Chang SH, Esplugues E, Flavell RA, Tian Q, Dong C. Bcl6 expression specifies the T follicular helper cell program in vivo. Journal Of Experimental Medicine 2012, 209: 1841-1852. PMID: 22987803, PMCID: PMC3457730, DOI: 10.1084/jem.20120219.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibody FormationCell DifferentiationCluster AnalysisDNA-Binding ProteinsGene ExpressionGene Expression ProfilingGene OrderGene TargetingGenes, ReporterGerminal CenterImmunologic MemoryMiceMice, TransgenicProto-Oncogene Proteins c-bcl-6Receptors, CXCR5T-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerTranscription, GeneticConceptsEffector T cell lineagesFollicular helper cellsT cell differentiationT-cell lineageGerminal center reactionTfh cellsHelper cellsImmune responseReporter miceCenter reactionBCL6 expressionFide markerBona fide markersEarly phaseVivoBCL6Pivotal roleCell lineagesCell differentiationCellsCell programCXCR5TfhTranscription factorsReporter systemEffector CD4+ T Cell Expression Signatures and Immune-Mediated Disease Associated Genes
Zhang W, Ferguson J, Ng SM, Hui K, Goh G, Lin A, Esplugues E, Flavell RA, Abraham C, Zhao H, Cho JH. Effector CD4+ T Cell Expression Signatures and Immune-Mediated Disease Associated Genes. PLOS ONE 2012, 7: e38510. PMID: 22715389, PMCID: PMC3371029, DOI: 10.1371/journal.pone.0038510.Peer-Reviewed Original ResearchConceptsDifferential gene expressionGenome-wide association studiesGene expressionCell differentiationDisease locusT cell differentiationExpression signaturesDifferential regulation patternsDisease association signalsDisease-associated genesPromoter methylation studiesGenomic lociTransmembrane domainRegulation patternsFunctional pathwaysAssociation studiesMethylation studiesAssociated geneAbundant isoformGenesLociMolecular resolutionPromoter methylationRNAseqCritical role