Rabbit model of ocular indirect photodynamic therapy using a retinoblastoma xenograft
Kim JW, Jacobsen B, Zolfaghari E, Ferrario A, Chevez-Barrios P, Berry JL, Lee DK, Rico G, Madi I, Rao N, Stachelek K, Wang LC, Gomer C. Rabbit model of ocular indirect photodynamic therapy using a retinoblastoma xenograft. Graefe's Archive For Clinical And Experimental Ophthalmology 2017, 255: 2363-2373. PMID: 28971251, DOI: 10.1007/s00417-017-3805-8.Peer-Reviewed Original ResearchConceptsRetinoblastoma xenograftsRabbit retinaPhotodynamic therapyLaser delivery systemTreatment of retinoblastomaPre-clinical studiesPhase 1Intraocular retinoblastomaIntravenous verteporfinRetinal scarsSubretinal tumorsDelivery systemRetinal damageRight eyeHistopathologic examinationOcular toxicityTumor necrosisOcular damageControl rabbitsTreatment durationRabbit modelVerteporfinWavelength diode laserThermal burnsPDT treatmentLong‐term outcomes of Group D retinoblastoma eyes during the intravitreal melphalan era
Berry JL, Shah S, Bechtold M, Zolfaghari E, Jubran R, Kim JW. Long‐term outcomes of Group D retinoblastoma eyes during the intravitreal melphalan era. Pediatric Blood & Cancer 2017, 64 PMID: 28646513, DOI: 10.1002/pbc.26696.Peer-Reviewed Original ResearchConceptsGroup D eyesGroup D retinoblastoma eyesD eyesSystemic chemoreductionIntravitreal melphalanSalvage rateRetinoblastoma eyesIntravitreal melphalan injectionRetrospective chart reviewOverall salvage ratePrimary outcome measurementLong-term outcomesExternal beam radiationOcular salvageSalvage therapyVitreous seedsChart reviewGlobe salvageIntravitreal injectionKaplan-MeierTreatment modalitiesTumor recurrenceMelphalan injectionOutcome measurementsMelphalan